CAS: 98-57-7; 4-Chlorophenyl Methyl Sulfone

上下游产品

4-chlorophenyl methyl sulfide methanesulfonyl chloride chlorobenzene sodium p-chlorobenzenesulphinate 1-(4-(methylsulfonyl)phenyl)piperidine (4-(methylsulfonyl)phenyl)(phenyl)sulfane (4-methanesulfonylphenyl)-N,N-dimethyl-amine 1-(4-methanesulfonyl-phenylsulfanyl)-4-methoxy-benzene

对-氯苯基甲基亚砜置于cytochrome P-450,Reductase,氧气,还原型辅酶ii(Nadph)四钠盐体系中,用 水 作为反应溶剂,化学反应生成 4-氯苯基甲基砜
参考文献:通过纯化的细胞色素p-450的重构系统促进亚砜酶促氧化为砜的一种电子转移机理
标题:通过纯化的细胞色素p-450的重构系统促进亚砜酶促氧化为砜的一种电子转移机理
摘要:通过使用纯化的细胞色素p-450的重构系统对亚砜酶s-氧化为砜的动力学进行了研究.在log(vmax)与亚砜的单电子氧化电位之间观测到线性相关性,表明亚砜的氧化是通过一个电子转移过程进行的,到达酶的活性"烯类"中间体.
DOI:10.1016/s0040-4039(00)86881-1

专利信息

专利号:US-2022401561-A1
优先权日:2019-09-30
标题 :Protein-macromolecule conjugates and methods of use thereof
发明人：SONG YUNTAO; LI HUI; ZHOU HAIPING; LIAO CHUAN
权利人:BEIJING XUANYI PHARMASCIENCES CO LTD
摘要:The present disclosure provides protein-macromolecule conjugates, releasable linkers, and macromolecules, as defined herein. The disclosed conjugates provide unique properties that ae based at least upon the properties of linker and number of linker-Macromolecule moieties. Also provided herein are a method of synthesis and use of conjugates in treating diseases and disorders.

专利号:CN-111925308-A
优先权日:2020-08-13
标 题:A kind of method for photocatalytic synthesis of N-substituted sulfonediimide

专利号:CN-111925308-B
优先权日:2020-08-13
标 题:A kind of method for photocatalytic synthesis of N-substituted sulfonediimide

专利号:US-2008194629-A1
优先权日:2005-05-03
标题 :3-Mono-and 3,5-Disubstituted Piperidine Derivatives as Renin Inhibitors
发明人：BAESCHLIN DANIEL KASPAR; BREITENSTEIN WERNER; EHRHARDT CLAUS; MAIBAUM JUERGEN KLAUS; OSTERMANN NILS; ZIMMERMANN JUERG; RUDISSER SIMON; VANGREVELINGHE ERIC; IRIE OSAMU; UMEMURA ICHIRO; SUZUKI MASAKI; MOGI MUNETO; KANAZAWA TAKANORI; YOKOKAWA FUMIAKI; NIHONYANAGI ATSUKO
权利人:BAESCHLIN DANIEL KASPAR; BREITENSTEIN WERNER; EHRHARDT CLAUS; MAIBAUM JUERGEN KLAUS; OSTERMANN NILS; ZIMMERMANN JUERG; RUDISSER SIMON; VANGREVELINGHE ERIC; IRIE OSAMU; UMEMURA ICHIRO; SUZUKI MASAKI; MOGI MUNETO; KANAZAWA TAKANORI; YOKOKAWA FUMIAKI; NIHONYANAGI ATSUKO
摘要:The invention relates to 3,5-piperidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; pharmaceutical formulations comprising a 3,5-piperidine compound, and/or a method of treatment comprising administering a 3,5-piperidine compound, a method for the manufacture of a 3,5-piperidine compound, and novel intermediates and partial steps for their synthesis. Especially, the 3,5-piperidine compounds have the formula I, wherein the symbols have the meanings described in the specification.

专利号:US-8513241-B2
优先权日:2008-03-28
标题 :3,4-dihydro-2H-pyrazino[1,2-A]indol-1-one derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
发明人：CERVI GIOVANNI; D ANELLO MATTEO; PAPEO GIANLUCA MARIANO ENRICO; SALOM BARBARA
权利人:CERVI GIOVANNI; D ANELLO MATTEO; PAPEO GIANLUCA MARIANO ENRICO; SALOM BARBARA; NERVIANO MEDICAL SCIENCES SRL
摘要:Compounds which are 3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one derivatives or pharmaceutically acceptable salts thereof, their preparation process and pharmaceutical compositions comprising them are disclosed; these compounds are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, viral infection, prevention of AIDS development in HIV-infected individuals, cell proliferative disorders, autoimmune and neurodegenerative disorders; also disclosed is a process under Solid Phase Synthesis conditions for preparing the compounds of the invention and chemical libraries comprising a plurality of them.

专利号:CN-118978464-A
优先权日:2024-07-31
标 题:Synthesis method of p-methylsulfonyl benzaldehyde