CAS: 883106-74-9; N-(6-Methylpyridin-2-yl)Piperidine-3-Carboxamide

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📜(+/-)-N-Fmoc-3-哌啶甲酸 Fmoc-Dl-哌啶甲酸置于氯化亚砜,碳酸氢钠,4-氨甲基哌啶,N,N-二甲基甲酰胺体系中,用 二氯甲烷,氯仿 作为反应溶剂,化学反应 16.0H,反应生成 N-(6-甲基吡啶-2-基)哌啶-3-甲酰胺
参考文献:Design And Synthesis Of Noncompetitive Metabotropic Glutamate Receptor Subtype 5 Antagonists
标题:Design And Synthesis Of Noncompetitive Metabotropic Glutamate Receptor Subtype 5 Antagonists
摘要:A Series Of Diaryl Amides Was Designed And Synthesized As Novel Nonethynyl Mglur5 Antagonists. The Systematic Variation Of The Pharmacophoric Groups Led To The Identification Of A Lead Compound That Demonstrated Micromolar Affinity For The Mglur5. Further Optimization Resulted In Compounds With Improved Binding Affinities And Antagonist Profiles,In Vitro. (C) 2006 Elsevier Ltd. All Rights Reserved.
DOI:10.1016/j.Bmcl.2006.04.032