CAS: 772-59-8; 2-(3-Bromo-4-Methoxyphenyl)Acetonitrile

上下游产品

CAS号89978-72-3 4-(bromomethyl)... | CAS号143-33-9 氰化钠 | CAS号34841-06-0 3-溴-4-甲氧基苯甲醛 | CAS号38493-59-3 3-溴-4-甲氧基苄醇 | CAS号701-94-0 2-溴-4-氯甲基-1-甲氧基苯 | CAS号151-50-8 氰化钾 | CAS号123-11-5 4-甲氧基苯甲醛; 对甲氧基苯... | CAS号774-81-2 3-溴-4-甲氧基苯乙酸 | CAS号159465-27-7 2-(3-溴-4-甲氧基苯基)乙胺

📜对甲氧基苯乙腈置于n-溴代丁二酰亚胺(Nbs),Palladium Diacetate,Copper(II) Bis(Trifluoromethanesulfonate)体系中,用 1,2-二氯乙烷 作为反应溶剂,以72%的收率获得产物3-溴-4-甲氧基苯乙腈
参考文献:钯催化,苄基腈,芳基温瑞布酰胺和苯胺的邻位选择性c-h卤化反应
标题:钯催化,苄基腈,芳基温瑞布酰胺和苯胺的邻位选择性c-h卤化反应
摘要:本文报道了钯催化的邻位选择性c-h卤化方法.这项工作的重点是在存在活化的c(sp 3)-H键的情况下对苄腈进行高选择性的c(sp 2)-H官能化,这将导致卤代产物的非常好收率和极好的区域选择性.与苄基腈一起,已经评估了使用非质子条件转化的芳基weinreb酰胺和苯胺化物的转化率.机理研究在反应途径和指导小组能力方面产生了有趣的方面.
DOI:10.1021/acs.Joc.6B02731

专利信息

专利号:US-4460604-A
优先权日:1976-06-03
标 题 :4-Amino-4-aryl-cyclohexanones
发明人：LEDNICER DANIEL
权利人:UPJOHN CO
摘要:A class of 4-amine-4-arylcyclohexanones, their ketals, and acid addition salts have been synthesized and found to be useful for relieving pain in animals. Their analgesic activity appears to be of high order, and in addition some exhibit narcotic antagonist activity that is useful in modifying the cardiovascular, respiratory, and behavioral depression caused by other analgesics. Several show mixed analgesic and narcotic antagonist activity. Preferred compounds of the class are 4-(m-hydroxyphenyl)-4-dimethylaminocyclohexanone ethylene ketal, and 4-(m-hydroxyphenyl)-4-(n-butylmethylamino)cyclohexanone ethylene ketal as free bases and as their hydrochloride salts. Processes for synthesis and intermediates are described. Unit dosage forms and therapeutic treatments are disclosed.