CAS: 6589-55-5; α-(Methylaminomethyl)Benzyl Alcohol

该化合物是一种可被用于制药合成和不对称催化的手性β-氨醇化合物,其结构结构既具有氢氧基,又具有附属于苯基替代乙烷主干体的甲基氨基组,使其成为培养生物活性分子的多功能中间体.该化合物的立体化学学在对应选择性反应中特别有用,它可以作为手工业催化剂的固定或构件. 它在标准条件下的稳定性和与普通有机溶剂的兼容性增强了其在合成工作流程中的实用性. 研究人员也可以探索其药物开发的衍生物,因为它在结构上与药用类的氨有相似性.

结构式图片

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

styrene oxide methylamine formaldehyd 2-nitro-1-phenylethan-1-oldimethyl-(3-methyl-5-phenyl-[1,3,2]oxazaphospholidin-2-yl)-amine S-(2-methylamino-1-phenyl-ethyl ester)thiosulfuric acid S-(2-methylamino-1-phenyl-ethyl ester) 5-phospha-spiro[4.4]nonane4,9-dimethyl-2,7-diphenyl-1,6-dioxa-4,9-diaza-5λ5-phospha-spiro[4.4]nonane 3-methyl-5-phenyloxazolidin-2-one

合成工艺路线路线简述

    📜N-Methyl-2-Hydroxy-2-Phenylethanamide置于lithium Aluminium Tetrahydride体系中,用 四氢呋喃 作为反应溶剂,化学反应 8.0H,以95.6%的收率获得产物α-(甲氨甲基)苯甲醇
    参考文献:Moehre,H.; Kamper,Ch.,Pharmazie,1983,Vol. 38,# 8,P. 512-520
    标题:Moehre,H.; Kamper,Ch.,Pharmazie,1983,Vol. 38,# 8,P. 512-520

    海关参考信息

    专利信息


    专利号:WO-0140193-A1
    优先权日:1999-12-03
    标题:Method for the synthesis of pyrazolines
    发明人:BOLDI ARMEN M
    权利人:CHEMRX ADVANCED TECHNOLOGIES I; BOLDI ARMEN M
    摘要:The present invention provides a method for the synthesis of compounds of Formula (I). Also claimed are novel intermediates and their methods of synthesis.

    专利号:US-4217452-A
    优先权日:1974-02-09
    标 题:Synthesis for the preparation of tetracyclic compounds
    发明人:OLIVIE JACQUES
    权利人:AKZONA INC
    摘要:The invention relates to a new synthesis for the preparation of tetracyclic compounds of the general formula: ##STR1## as well as the pharmaceutically acceptable salts thereof, in which: n is the number 1 or 2, n m is the number 1, if n=2 and the number 2, if n=1, n R 1 and R 2 stand for hydrogen, hydroxy, halogen, lower alkyl (1-4 C), lower alkoxy (1-4 C) or trifluoromethyl and n R 3 represents hydrogen, alkyl (1-6 C), aralkyl (7-10 C) or an amino alkyl group (1-6 C), in which the nitrogen atom has been substituted by two alkyl groups (1-4 C), or the nitrogen atom forms part of a heterocyclic 5- or 6-membered ring, n having valuable biological properties.

    专利号:US-4254031-A
    优先权日:1974-02-09
    标 题:Synthesis for the preparation of tetracyclic compounds
    发明人:OLIVIE JACQUES
    权利人:AKZONA INC
    摘要:The invention relates to a new synthesis for the preparation of tetracyclic compounds of the general formula ##STR1## as well as the pharmaceutically acceptable salts thereof, in which: n is the number 1 or 2, n m is the number 1, if n=2 and the number 2, if n=1, n R 1 and R 2 stand for hydrogen, hydroxy, halogen, lower alkyl (1-4 C), lower alkoxy (1-4 C) or trifluoromethyl and n R 3 represents hydrogen, alkyl (1-6 C), aralkyl (7-10 C) or an amino alkyl group (1-6 C), in which the nitrogen atom has been substituted by two alkyl groups (1-4 C), or the nitrogen atom forms part of a heterocyclic 5- or 6-membered ring, n having valuable biological properties.

    专利号:US-2018111958-A1
    优先权日:2008-12-02
    标 题 :Method for the synthesis of phosphorus atom modified nucleic acids

    专利号:EP-1529037-A2
    优先权日:2002-05-15
    标 题:Synthesis of 2-alkylcysteines, 2-(hydroxylated phenyl)-4-alkylthiazoline-4-carboxylic acids and derivatives thereof

    专利号:US-6417195-B1
    优先权日:1999-02-22
    标题 :Isoquinoline derivatives and isoquinoline combinatorial libraries
    发明人:LEBL MICHAL
    权利人:LION BIOSCIENCE AG
    摘要:The present invention provides the synthesis of heterocyclic compounds based on the isoquinoline ring. More specifically, the invention provides novel isoquinoline derivatives as well as novel libraries comprised of such compounds.

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献

    [参考文献]: C B Davis, Et Al. The Vasoactive Potential Of Halostachine, An Alkaloid Of Tall Fescue (Festuca Arundinaceae, Schreb) In Cattle. Vet Hum Toxicol. 1983 Dec;25(6):408-11.
    [参考文献]: H E Shannon, Et Al. Physiologic Effects And Plasma Kinetics Of Phenylethanolamine And Its N-Methyl Homolog In The Dog. J Pharmacol Exp Ther. 1981 May;217(2):379-85.
    [参考文献]: Jin Ho Lee, Et Al. Mma/mpeoma/vsa Copolymer As A Novel Blood-Compatible Material: Ex Vivo Platelet Adhesion Study. J Mater Sci Mater Med. 2004 Feb;15(2):155-9.
    [参考文献]: Neil Chester, Et Al. Elimination Of Ephedrines In Urine Following Multiple Dosing: The Consequences For Athletes, In Relation To Doping Control. Br J Clin Pharmacol. 2004 Jan;57(1):62-7.
    [参考文献]: O Suzuki, Et Al. Characterization Of N-Methylphenylethylamine And N-Methylphenylethanolamine As Substrates For Type A And Type B Monoamine Oxidase. Biochem Pharmacol. 1980 Oct 1;29(19):2663-7.

    合成参考文献


    摘要:Llopis, Q.; Ayad, T.; Phansavath, P.; Ratovelomanana-Vidal, V., Science of Synthesis: Catalytic Reduction in Organic Synthesis, (2018) 2, 109.
    摘要:Journal of Pharmacology and Experimental Therapeutics., 106(341), 1952 []
    摘要:C. Sinistri and L. Villa. Farmaco. Ed. Sci. 17, 969, 967 (1962).
    摘要:L. Villa and C. Sinistri. Farmaco. Ed. Sci. 18, 877 (1963).
    参考文献:10.1023/b:jmsm.0000011817.47636.59
    摘要:Lee JH, Oh SH, Kim WG. MMA/MPEOMA/VSA copolymer as a novel blood-compatible material: ex vivo platelet adhesion study. Journal of Materials Science: Materials in Medicine. 2004 Feb;15(2):155–9. doi: 10.1023/b:jmsm.0000011817.47636.59.
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