专利号:US-2025162968-A1 优先权日:2022-02-02 标 题 :Method for Producing Ionizable Lipids or Intermediates for the Synthesis of Such Lipids 发明人:ATMURI N D PRASAD; ARNOLD DEAGLAN; SAADATI FARIBA; KUREK DANIEL; KULKARNI JAYESH; WITZIGMANN DOMINIK; CIUFOLINI MARCO A 权利人:NANOVATION THERAPEUTICS INC 摘要:The present disclosure provides a method for producing one or more intermediates for the synthesis of one or more ionizable lipids, the method comprising: (i) producing a beta-ketoacid by reacting a cyclic ester, a terminal hydroxyester or a derivative thereof, a dicarboxylic acid half ester, or an acid chloride derivative of the dicarboxylic acid half ester, in a condensation reaction, thereby producing the beta-ketoacid or a beta-ketoester that is hydrolyzed to produce the beta-ketoacid; and (ii) decarboxylating the beta-ketoacid, thereby producing the one or more intermediates, wherein the one or more intermediates have a structure that may be defined by Formula A. Further provided is a method for producing ionizable lipid from the intermediate comprising adding an ionizable head group moiety to (a) a ketone group of one or more intermediates having the structure that may be defined by Formula A; or (b) a corresponding alcohol of the intermediate.
专利号:US-4616097-A 优先权日:1984-10-22 标 题:Process for low pressure synthesis of ethylene glycol from synthesis gas plus formaldehyde 发明人:KNIFTON JOHN F 权利人:TEXACO INC 摘要:This invention relates to the manufacture of ethylene glycol and more particularly to a low pressure process for making ethylene glycol comprising reacting synthesis gas, i.e. a mixture of carbon monoxide and hydrogen, plus formaldehyde in the presence of a homogenous liquid catalyst containing an effective amount of cobalt-containing compound and a silicon-containing promoter at a temperature of at least 50 DEG C. and a pressure of at least 500 psi.
专利号:WO-0009528-A1 优先权日:1998-08-13 标题:Lower alkyl ester recycling synthesis 发明人:KENNEALLY COREY JAMES; TROUT JAMES EARL; SARAMA ROBERT JOSEPH; HOWIE JOHN KEENEY 权利人:PROCTER & GAMBLE; KENNEALLY COREY JAMES; TROUT JAMES EARL; SARAMA ROBERT JOSEPH; HOWIE JOHN KEENEY 摘要:Process for synthesizing and purifying polyol fatty acids polyesters or other nondigestible fats selected from the group of esterified linked alkoxylated polyols and esterified epoxide extended polyols, in which unreacted lower alkyl ester is recovered from a reaction mixture and recycled for use in the synthesis of the nondigestible fat. The process includes the steps of reacting an excess of lower alkyl ester with polyol to esterify hydroxyl groups thereof and form polyol fatty acid polyester, separating at least a portion of the unreacted lower alkyl ester from the polyol fatty acid polyester, and recycling the separated unreacted lower alkyl ester for further reaction with polyol or partially esterified polyol. The recycled lower alkyl ester is substantially free of lower alkyl ester degradation reaction products, such as carbonyls and free fatty acids.
专利号:US-2010055750-A1 优先权日:2008-09-03 标 题:Polyester synthesis 发明人:WOSNICK JORDAN H 权利人:XEROX CORP 摘要:The present disclosure provides for enzymatic polymerization to produce polyester resins suitable for use in manufacturing toners. In embodiments, crystalline copolymers, which are polyesters, may be synthesized from lactones, cyclic anhydrides, cyclic carbonates, and combinations thereof. These crystalline copolymers, in turn, may be utilized in the synthesis of toner particles.
专利号:US-6166212-A 优先权日:1999-05-20 标 题 :Process for the synthesis of N-(hydroxyalkoxy) substituted hindered amine stabilizers 发明人:GALBO JAMES P; DETLEFSEN ROBERT E; DIFAZIO MICHAEL P; GRACE HENRY C; KUELL CHRISTOPHER 权利人:CIBA SC HOLDING AG 摘要:N-(Hydroxyalkoxy) hindered amine stabilizers are prepared by reacting the corresponding N-oxyl compound with a peroxide or organic hydroperoxide and a catalytic amount of a metal salt or metal-ligand complex in an alcohol solvent. These N-(hydroxyalkoxy) hindered amines are particularly useful as stabilizers for polyolefins, thermoplastic polyolefins and automotive coating compositions.
专利号:US-4476326-A 优先权日:1983-02-03 标题 :Process for the synthesis of ethanol and acetaldehyde using cobalt compounds with novel promoters 发明人:LIN JIANG-JEN; KNIFTON JOHN F 权利人:TEXACO INC 摘要:Ethanol and/or acetaldehyde are prepared in good yield by contacting methanol, hydrogen and carbon monoxide with a catalyst system comprising a cobalt-containing compound and a promoter in the presence of an inert oxygenated solvent at a temperature of from about 50 DEG C. to about 350 DEG C. and a pressure of at least 500 psig or greater. The combination of cobalt-containing compound and promoter may be (a) a cobalt-containing compound with an organo-sulphur compound, (b) an iodide-containing cobalt compound with a nitrogen-containing compound as promoter, and (c) a cobalt-containing compound with 1,1'-bis(diphenylphosphino)ferrocene.
摘要:Besson, M.; Pinel, C., Science of Synthesis: Catalytic Reduction in Organic Synthesis, (2017) 2, 263. 摘要:Diéguez, M.; Bäckvall, J.-E.; Pàmies, O., Science of Synthesis, (2019) , 162. 摘要:Wu, T.; Moeller, K. D., Science of Synthesis: Special Topics, (2021) 1, 481. 摘要:Journal of Pharmaceutical Sciences., 62(1596), 1973 [] 摘要: