CAS: 58749-51-2; 2-(Thien-2-yl)Ethylisocyanate

上下游产品

[2-(2-thyenyl)ethyl]amine bis(trichloromethyl) carbonate 2-{4-[3-(2-methylpyrrolidin-1-yl)propoxy]phenyl}-N-(2-thien-2-ylethyl)-6,7-dihydro[1,3]thiazolo[5,4-c]pyridine-5(4H)-carboxamide sodium [(2,3-difluorobenzyl) 5-acetamido-9-(4-chlorobenzamido)-3,5,9-trideoxy-7,8-O-isopropylidene-4-O-(2-(2-thienyl)ethylcarbamoyl)-D-glycero-α-D-galacto-2-nonulopyranosid]onate 4-[3-(2-thiophen-2-yl-ethyl)ureido]phenyl sulfamate

📜噻吩乙胺,三光气置于碳酸氢钠体系中,用 二氯甲烷,水 作为反应溶剂,化学反应 2.5H,反应生成 异氰酸-2-(2-噻吩基)乙基酯
参考文献:氨基噻吩并吡啶酮的流入光氧化产生亚氨基吡啶二酮ptp4A3磷酸酶抑制剂
标题:氨基噻吩并吡啶酮的流入光氧化产生亚氨基吡啶二酮ptp4A3磷酸酶抑制剂
摘要:连续流光氧化7-氨基噻吩并[3,2-C]吡啶-4(5 H)-产生7-亚氨基噻吩并[3,2-C]吡啶-4,6(5 H,7 H)-二酮已经开发出利用环境空气作为唯一反应物的技术.n-H亚胺形成为主要产物,并且出色的官能团耐受性和克级转化率(无需色谱纯化)可实现氨基噻吩并吡啶酮支架的简便后期分散.几种类似物在体外具有对癌症相关蛋白酪氨酸磷酸酶ptp4A3的有效抑制作用,并且sar支持探索性对接模型.
DOI:10.1039/c9Ob00025A

专利信息

专利号:US-7138526-B1
优先权日:1999-06-15
标 题 :Solid phase synthesis of n,n-disubstituted diazacycloalkylcarboxy derivatives
发明人：HERPIN TIMOTHY F; MORTON GEORGE C; SALVINO JOSEPH M
权利人:AVENTIS PHARMA INC
摘要:A method for the solid phase synthesis of N,N-disubstituted diazacycloalkylcarboxy derivatives of general formula (I) and (II) is claimed. Examples include piperazine-2-carboxamide. The method is applicable to the synthesis or large combinatorial libraries

专利号:EP-0522956-B1
优先权日:1991-07-08
标 题 :Preparation of 2-(2-thienyl) ethylamine and synthesis of thieno [3,2-C] pyridine derivatives therefrom
发明人：HARRINGTON PETER J; SANCHEZ IGNACIO H
权利人:SANOFI SA
摘要:Compounds of the formulae: and wherein: R<1>, R<2>, R<3> and R<4> are independently hydrogen, lower alkyl of one to six carbon atoms, aryl or substituted aryl; are advantageously converted to isocyanurate compounds, 2-(2-thienyl)ethylamine compounds and thieno[3,2-c]pyridine derivatives and the pharmaceutically acceptable salts thereof, particularly ticlopidine hydrochloride.

专利号:US-2005192265-A1
优先权日:2003-03-20
标 题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds
发明人：THOMPSON RICHARD C; WILKIE STEPHEN; STACK DOUGLAS R; VANMETER ELDON E; SHI QING; BRITTON THOMAS C; AUDIA JAMES E; REEL JON K; MABRY THOMAS E; DRESSMAN BRUCE A; CWI CYNTHIA L; HENRY STEVEN S; MCDANIEL STACEY L; STUCKY RUSSELL D; PORTER WARREN J
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions that include a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:US-6906056-B2
优先权日:1998-06-22
标 题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
发明人：THOMPSON RICHARD C; WILKIE STEPHEN; STACK DOUGLAS R; VANMETER ELDON E; SHI QING; BRITTON THOMAS C; AUDIA JAMES E; REEL JON K; MABRY THOMAS E; DRESSMAN BRUCE A; CWI CYNTHIA L; HENRY STEVEN S; MCDANIEL STACEY L; STUCKY RUSSELL D; PORTER WARREN J
权利人:LILLY CO ELI
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions that include a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:EP-0522956-A2
优先权日:1991-07-08
标 题 :Preparation of 2-(2-thienyl) ethylamine and synthesis of thieno [3,2-C] pyridine derivatives therefrom

专利号:DE-69217282-T2
优先权日:1991-07-08
标题 :Preparation of 2- (2-thienyl) ethylamine and synthesis of thieno (3,2-c) pyridine derivatives therefrom