CAS: 5370-25-2; 2-Acetyl-5-Bromothiophene

上下游产品

CAS号88-15-3 2-乙酰基噻吩 | CAS号1003-09-4 2-溴噻吩 | CAS号75-36-5 乙酰氯 | CAS号108-24-7 乙酸酐 | CAS号64992-14-9 2-cyano-Acetic ... | CAS号141-82-2 丙二酸 | CAS号1956-45-2 1-(噻吩-2-基)乙酮肟 | CAS号114773-97-6 2-乙酰基噻吩邻甲基肟 | CAS号3141-27-3 2,5-二溴噻吩 | CAS号1087-01-0 1-[5-(5-thiophe... | CAS号3515-18-2 3,4-二甲基噻吩 | CAS号18494-73-0 5,5-二乙酰基-2,2-联噻吩 | CAS号492-97-7 2,2'-双噻吩 | CAS号423768-50-7 5-(5-溴-2-噻吩基)-3... | CAS号465514-11-8 3-甲酰基-5-(噻吩-2-基)异恶唑 | CAS号36983-36-5 2,4-二氧代-4-(2-噻吩)丁酸乙酯 | CAS号886361-46-2 1-(5-(4-FLUOROP... | CAS号398-23-2 4,4'-二氟联苯 | CAS号90924-54-2 5-(噻吩-2-基)异恶唑-3-甲酸乙酯

2-乙酰基噻吩置于oxone,Sodium Bromide体系中,用 甲醇,水 作为反应溶剂,化学反应 3.0H,以60%的收率获得产物2-乙酰基-5-溴噻吩
参考文献:使用 Oxone® 和卤化钠卤化芳香甲基酮
标题:使用 Oxone® 和卤化钠卤化芳香甲基酮
摘要:在 Oxone® 的甲醇水溶液中,芳族甲基酮在用卤化钠处理时发生 α-卤化.然而,富电子的杂芳族甲基酮优先提供环溴化产物.
DOI:10.1081/scc-100107011

专利信息

专利号:US-8192590-B1
优先权日:2008-04-14
标 题:Microwave-assisted formation of sulfonium photoacid generators
发明人：BELFIELD KEVIN D; YANEZ CICERON O
权利人:BELFIELD KEVIN D; YANEZ CICERON O; UNIV CENTRAL FLORIDA RES FOUND
摘要:Efficient method for preparing sulfonium photoacid generators (PAGs) by microwave-assisted reaction of diarylsufides in the presence of alkylaryliodonium salts. Microwave-assisted synthesis of the PAGs is significantly faster, reducing reaction time with less energy consumption. Reaction times using the microwave-assisted synthesis are in a range of from 90 to 420 faster than conventional thermal conditions. The photoacid quantum yields of several salts prepared by the microwave reaction were measured; the photoacid quantum yields of new sulfonium PAGs were in a range from 0.01 to 0.4 times greater than yields from conventional synthesis. Incorporating a nitro group in the structures of the sulfonium salts increased photoacid quantum yield, induced intersystem crossing and increased the efficiency of photoacid generation compounds.

专利号:US-5059709-A
优先权日:1990-11-13
标题 :Process for the synthesis of α-[(dialkylamino)substituted-methylene]-β-oxo-(substituted)propanentriles
发明人：DUSZA JOHN P; CHURCH ROBERT F
权利人:AMERICAN CYANAMID CO
摘要:A novel process for producing α-[(dialkylamino) substituted-methylene]β-oxo-(substituted) propanenitriles of the formula: ##STR1## where R, R 1 and R 2 are defined in the specification by reacting a substituted isoxazole with a diaklylamide dimethylacetal is provided.

专利号:EP-4116291-A1
优先权日:2020-03-04
标题:Synthesis of novel ep4 antagonist and use in cancers and inflammations

专利号:US-2023125494-A1
优先权日:2020-03-04
标题 :Synthesis of novel ep4 antagonist and use in cancer and inflammation

专利号:CN-113354585-A
优先权日:2020-03-04
标 题:Synthesis of novel EP4 antagonists and their use in cancer and inflammation

专利号:US-9938258-B2
优先权日:2012-11-29
标 题:Substituted 2,3-dihydrobenzofuranyl compounds and uses thereof
发明人：BALOGLU ERKAN; SHECHTER SHARON; SHACHAM SHARON; MCCAULEY DILARA; SENAPEDIS WILLIAM; GOLAN GALI; KALID ORI
权利人:KARYOPHARM THERAPEUTICS INC
摘要:The invention generally relates to substituted 2,3-dihydrobenzofuranyl compounds, and more particularly to a compound represented by Structural Formula I: n nor a pharmaceutically acceptable salt thereof, wherein the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of Structural Formula I, or a pharmaceutically acceptable salt or composition thereof, e.g., in the treatment of cancer (e.g., mantle cell lymphoma), and other diseases and disorders.