CAS: 4114-28-7; Diethyl Hydrazine-1,2-Dicarboxylate

相似化合物

16466-61-8 5394-50-3 185456-26-2

上下游产品

CAS号4143-61-7 diethyl azodica... | CAS号1972-28-7 偶氮二甲酸二乙酯 | CAS号541-41-3 氯甲酸乙酯 | CAS号622-40-2 N-(2-羟乙基)吗啉 | CAS号6702-50-7 异香兰酸甲酯 | CAS号2240-88-2 3,3,3-三氟丙-1-醇 | CAS号1264239-29-3 (2S,4S)-allyl 2... | CAS号1264240-64-3 allyl (2S)-2-[(... | CAS号1121-60-4 吡啶-2-甲醛 | CAS号17356-77-3 6,7-dimethoxyci... | CAS号1972-28-7 偶氮二甲酸二乙酯 | CAS号104-88-1 对氯苯甲醛 | CAS号16396-49-9 ethyl N-benzyl-... | CAS号1617-13-6 1,2-Hydrazinedi... | CAS号52944-50-0 diethyl diazina... | CAS号540-73-8 1,2-二甲基肼

📜氯甲酸乙酯置于sodium Carbonate,肼体系中,用 乙醇,水 作为反应溶剂,化学反应 0.5H,以79%的收率获得产物1,2-肼二羧酸二乙酯
参考文献:Copper-Catalyzed Cross-Coupling Between (E)-1,2-Diiodoethene And Carbazates: Entry To β-Functionalized N-Alkenylcarbazates
标题:Copper-Catalyzed Cross-Coupling Between (E)-1,2-Diiodoethene And Carbazates: Entry To β-Functionalized N-Alkenylcarbazates
摘要:目的: 这项工作旨在拓宽制备功能化 N-烯基咔嗪酸盐. 背景: 烯基咔嗪酸盐一般通过 Aza-Baylis-Hillman 反应,亲核 酮或炔烃的串联羰基化/酰胺化反应制备. 目标: 这项工作的目的是开发一种制备功能化烯基咔嗪酸盐的方法. 的方法,以解决上述方法中遇到的问题(使用缺电子烯烃 缺电子的烯烃,使用计量单位量的金属,只能制备对称的二咔嗪酸盐). 方法: 利用铜催化的乙烯基二碘化物与咔唑盐之间的交叉偶联来制备 官能化 N-烯基咔嗪酸盐. 结果: 合成了各种 β-碘乙烯基咔嗪盐,收率高达非常好.其中 得率最高.β-碘乙烯基咔嗪酸盐的功能化表明 碘乙烯基咔唑酸盐的官能化表明,通过过渡金属催化,这些分子中的碘乙烯基可以被多种官能团取代. 过渡金属催化的偶联反应. 结论 铜催化的交叉偶联反应能有效地制备功能化的 N-烷基咔嗪酸盐.
DOI:10.2174/1570180818666210803165347

专利信息

专利号:US-5521310-A
优先权日:1992-10-07
标 题 :Process to obtain benzoxazines to be used for the synthesis of ofloxazine, levofloxazine and derivatives
发明人：CARRETERO GONZALVEZ JUAN-CARLO; VICIOSO SANCHEZ MERCEDES; GARCIA RUANO JOSE-LUIS
权利人:ETILO DERIVADOS
摘要:A process to obtain benzoxazines useful for the synthesis of Ofloxazine, Levofloxazine and derivatives. The benzoxacines (I) where Xb is an halogen and R 1 is H, alkyl or alkenyl of up to 6 atoms of C or aryl, can be obtained by means of cycling a compound of formula (II) through the reaction with triphenylphosphine and ethyl azodicarboxilate. The compounds of formula (II) can be obtained through the reaction of a compound (III) with an adequate epoxide. Through the use of the adequate chiral epoxide it is possible to obtain the enantiomerically desired intermediate and, therefore and selectively, it is possible to obtain the desired final product with the adequate enantiomeric form without the need to carry out a resolution stage. n The Compounds (I) are useful and key intermediates for the synthesis of the antimicrobials Oflixazine and Levofloxazine. ##STR1##

专利号:US-12391725-B2
优先权日:2016-06-22
标题:Method for production of novel galeterone analogs and uses thereof
发明人：NJAR VINCENT C O; PURANIK PURUSHOTTAMACHAR; MURIGI FRANCIS
权利人:NJAR VINCENT C O; PURANIK PURUSHOTTAMACHAR; MURIGI FRANCIS; NAT INSTITUTES OF HEALTH NIH U S DEPT OF HEALTH AND HUMAN SERVICES DHHS U S GOVERNMENT
摘要:Galeterone and its C-3 analogs are of substantial interest because of their multi-target anticancer activities, including AR and Mnk degrading activities. Provided are novel procedures for gram-scale, high-yield synthesis of C-3 analogs of galeterone, including 3β-(1H-imidazole-1-yl)-17-(1H-benzimidazole-1-yl)-androsta-5,16-diene (galeterone 3β-imidazole) and 3β-(pyridine-4-ylmethoxy)-17-(1H-benzimidazol-1-yl)androsta-5,16-diene (galeterone 3β-pyridine methoxylate).

专利号:US-6051711-A
优先权日:1997-10-24
标 题 :Synthesis of swainsonine salts
发明人：TROPPER FRANCOIS; SHAH RAJAN N; SHARMA PRADEEP
权利人:GLYCODESIGN INC
摘要:A method for synthesizing swainsonine salts and intermediates thereof comprising subjecting a compound of the formula I wherein R2 and R2' are the same or different and represent alkyl, halogen, alkenyl, alkoxy, cycloalkyl or aryl which may be substituted, to acid hydrolysis in the presence of a C1-4 alkanol to obtain a crystalline salt of swainsonine; and optionally, recrystallizing the swainsonine salt from a C1-4 alkanol. The reaction may be used in combination with one or more additional reaction steps.

专利号:US-5106750-A
优先权日:1988-08-30
标 题:Enantio- and regioselective synthesis of organic compounds using enol esters as irreversible transacylation reagents
发明人：WONG CHI-HUEY; WANG YI-FONG; HENNEN WILLIAM J; BABIAK KEVIN A; DYGOS JOHN H; NG JOHN S
权利人:SEARLE & CO
摘要:A process for irreversible regio- and stereoselective enzyme catalyzed acylation of alcohols using enol esters as acylating reagents is disclosed. The present invention permits the selective modification of hydroxyl group(s) of chiral and meso alcohols, including sugars, organometallics, and glycosides. The enol freed upon transesterification rapidly tautomerizes to the corresponding volatile aldehyde or ketone thereby preventing the reverse reaction from occurring.

专利号:US-5374745-A
优先权日:1990-03-29
标题 :Process for the synthesis of propargyl alcohols and their use for production of prostaglandin precursors
发明人：KLAR ULRICH
权利人:SCHERING AG
摘要:The invention relates to a process for the production of prostaglandin precursors of formula I ##STR1## as well as their enantiomers in which X is A--W or W--A, n A is a --C.tbd.C-- group, n W is a hydroxymethylene group, in which the OH group can be functionally modified by etherification or esterification, n D is a straight-chain or branched-chain alkylene group with 2-5 C atoms each or a ##STR2## group, n i s 1 to 3, n E is a --C.tbd.C-- group or a --CR 3 â•?CR 4 group with R 3 and R 4 each meaning a hydrogen atom or a C 1 -C 4 alkyl group, n R 1 is a hydrogen atom or a hydroxy group, which can be functionally modified as in W, n R 2 is a straight-chain or branched-chain alkyl group with 1-7 C atoms, characterized in that vinyl bromides of formula II ##STR3## in which Z means the group ##STR4## and R 1 , W, D, E and R 2 have the above-indicated meanings and hydroxy groups unprotected in R 1 and W or represented by an optionally substituted benzoyl radical, a C 1 -C 6 alkanoyl group, a tetrahydropyranyl radical, a tetrahydrofuranyl radical, a trialkylsilyl group or a diphenylalkylsilyl group each with alkyl meaning a C 1 -C 4 alkyl, are reacted with anhydrous cesium acetate in the presence of 18-crown6.

专利号:US-4794108-A
优先权日:1984-04-24
标题:1-carboxymethoxy acetidinones and their production
发明人：KISHIMOTO SHOJI; SENDAI MICHIYUKI; OCHIAI MICHIHIKO
权利人:TAKEDA CHEMICAL INDUSTRIES LTD
摘要:A 2-azetidinone derivative having a group of the formula wherein R1 and R2 are the same or different and each represents a hydrogen atom, alkyl, aryl or arylalkyl which may have a substituent at the 1-position and an amino group, at the 3-position, which may be acylated or protected, its salt or ester, and methods of producing the same, (1) a method comprising subjecting a 2-azetidinone derivative having a group of the formula wherein the symbols are as defined above at the 1-position and an amino group at the 3-position, its salt or ester to an acylation or protective-group introduction reaction, and (2) a method comprising reacting a 2-azetidinone derivative having a hydroxy group at the 1-position and an amino group, at the 3-position, which may be acylated or protected, or its salt with a compound of the formula wherein W is a halogen atom; other symbols are as defined above, its salt or ester. The above objective compounds are utilizable as excellent antimicrobial agents or as valuable intermediates for the synthesis of the same.