CAS: 404-82-0; Fenfluramine Hydrochloride

上下游产品

Fenfluramine 3-(trifluoromethyl)phenylacetic acid 3-trifluoromethylphenylacetonitrile 3-(trifluoromethyl)phenylacetone

📜芬氟拉明置于盐酸体系中,用 甲基叔丁基醚,乙酸乙酯 作为反应溶剂,化学反应 1.0H,以96.52%的收率获得产物盐酸芬氟拉明
参考文献:Fenfluramine Compositions And Methods Of Preparing The Same
标题:Fenfluramine Compositions And Methods Of Preparing The Same
摘要:提供了制备芬氟拉明活性药物成分的方法.该方法的步骤包括(a)水解2-(3-(三氟甲基)苯基)乙腈组合物,以产生2-(3-(三氟甲基)苯基)乙酸组合物;(b)将2-(3-(三氟甲基)苯基)乙酸组合物与乙酸酐和催化剂反应,以产生1-(3-(三氟甲基)苯基)丙酮组合物;以及(c)使用硼氢化还原剂将1-(3-(三氟甲基)苯基)丙酮组合物与乙胺还原胺化,以产生芬氟拉明组合物.还提供了根据该方法制备的组合物和药用成分,包括芬氟拉明的药用可接受盐,并且在总三氟甲基异构体中的重量不到0.2%.

专利信息

专利号:US-3699148-A
优先权日:1956-03-05
标题 :Process for the synthesis of 2-hydroxy 4-methylthio butyronitrile
发明人：DARCAS CLAUDE; JOBERT RAYMOND; LAVIRON CHARLES
权利人:UGILOR
摘要:A process, either continuous or intermittent, for the synthesis of 2-hydroxy 4-methylthio butyronitrile which comprises adding an amount of methyl mercaptan to a mixture of acrolein cyanohydrin and a basic agent, said basic agent being used in an amount such that the pH of a solution obtained by diluting said mixture twenty times with distilled water is maintained between 7 and 8, said methyl mercaptan being 5 to 50 percent in excess of the stoichiometric amount relative to the cyanohydrin. The excess mercaptan is eliminated and can be recycled or reused for the continuous or intermittent process respectively.

专利号:US-4649036-A
优先权日:1979-01-26
标 题 :Process for the manufacture of zeolites 4A having a high crystallinity and a fine granulometry and being particularly suitable for the formulation of detergent compositions
发明人：PASTORELLO FABIO; TROGLIA CLAUDIO
权利人:MONTEDISON SPA
摘要:The synthesis of zeolites 4A having a high crystallinity and a fine granulometry is disclosed, by the addition in a first stage of a sodium silicate solution to a sodium aluminate solution (containing an excess of NaOH and heated to a temperature of from 50 DEG to 100 DEG C.), and by the crystallization in a second stage at a temperature of from 70 DEG to 105 DEG C., characterized in that the temperature of the sodium silicate solution is lower by at least twenty Centigrade degrees than that of the sodium aluminate solution, the molar ratios SiO2:H2O and SiO2:Na2O in the sodium silicate solution being respectively from 0.030 to 0.150 and from 1.95 to 2.30, and the weight ratio between the reaction mother liquor and the zeolite thus formed being from 6.5 to 20.

专利号:WO-2009093093-A1
优先权日:2008-01-21
标 题 :Industrial production process of diethyl carbonate (dec) by means of heterogeneous catalytic synthesis reactor fed by ethylic ether and carbon dioxide
发明人：TULINO ROSARIO ROCCO; SANTINO LETIZIA
权利人:TULINO ROSARIO ROCCO; SANTINO LETIZIA
摘要:Production process of liquid diethyl carbonate complex (DEC C2H5OCOOC2H5) by means of reactor of catalytic synthesis in heterogeneous phase fed by ethyl ether (C2H5OC2H5) (liquid) and carbon dioxide CO2 (gas). The compound synthesis occurs in the vertical tubular reactor working under pressure between 15 bar and 55 bar and temperature range between 1150C and 2350C. The different several sectors, with circular ring shape, are piled up in the entry area of reactor. The catalyst is composed by potassium carbonate (K2CO3) plus cobalt oxide (CoO) as reaction promoter and ethyl iodide (IC2H5) as reaction activator. The support is made by an alumina plus zeolite type 3A sponge sector whose several active sites allow a high yield conversion to organic carbonate for each reagent passing through in recycle pushed by the centrifugal compressor at magnetic dragging.

专利号:WO-2005102340-A1
优先权日:2003-05-30
标题 :Piperazine melanocortin-specific compounds
发明人：SHARMA SHUBH D; SHI YI-QUN; WU ZHIJUN; RAJPUROHIT RAMESH
权利人:PALATIN TECHNOLOGIES INC; SHARMA SHUBH D; SHI YI-QUN; WU ZHIJUN; RAJPUROHIT RAMESH
摘要:Melanocortin receptor-specific piperazine or ketopiperazine compounds having the structure (I); and stereoisomer and pharmaceutically acceptable salts thereof, where X is CH2 or C=O, R1, R2, and R3 are as described in the specification, preferably where R3 is a D-amino acid with at least one substituted or unsubstituted phenyl or naphthyl aromatic ring, and where R3 optionally further includes an amine capping group, a second amino acid residue or a second amino acid residue with an amine capping group, which compounds are agonists, antagonists or mixed agonists and antagonists at one or more melanocortin receptors, and having utility in the treatment of melanocortin receptor-related disorders and conditions. Methods of synthesis of compounds of structure (I), pharmaceutical compositions containing a compound of structure (I) and methods relating to the use thereof are also disclosed.

专利号:IT-1245413-B
优先权日:1991-02-25
标题 :METHOD FOR THE RECOVERY OF BASIC REAGENTS FOR THE SYNTHESIS OF ZBLAN GLASS FROM PURIFIED SOLUTIONS

专利号:IL-313204-A
优先权日:2021-12-15
标 题:Methods for the synthesis of complement factor d inhibitors