CAS: 395-35-7; 2-Hydroxy-2-(4-(Trifluoromethyl)Phenyl)Acetic Acid

上下游产品

CAS号455-19-6 对三氟甲基苯甲醛 | CAS号455-24-3 4-三氟甲基苯甲酸 | CAS号1891-90-3 4-(三氟甲基)苯甲酰胺

📜对三氟甲基苯甲醛,二氧化碳置于(4,4'-Di-Tert-Butyl-2,2'-Dipyridyl)-Bis-(2-Phenylpyridine(-1H))-Iridium(Iii) Hexafluorophosphate,1,3-二甲基-2-苯基-2H-苯并咪唑体系中,用 乙腈 作为反应溶剂,化学反应 1.0H,以74%的收率获得产物4-三氟甲基扁桃酸
参考文献:光催化甲醇阳离子/阴离子umpolung:将芳香醛和酮直接添加到二氧化碳中
标题:光催化甲醇阳离子/阴离子umpolung:将芳香醛和酮直接添加到二氧化碳中
摘要:我们开发了一种新的羰基化合物光催化聚合反应,以反应生成阴离子甲醇合成子.芳香醛或酮在铱光催化剂和 1,3-二甲基-2-苯基-2,3-二氢-1 H-苯并咪唑 (Dmbi) 作为还原剂的存在下与二氧化碳反应,在可见光照射下提供通过将所得的甲醇阴离子与亲电二氧化碳进行亲核加成,反应生成相应的α-羟基羧酸.
DOI:10.1021/acs.Orglett.1C02592

专利信息

专利号:US-8138272-B2
优先权日:2006-05-22
标 题:Preparation of polymer conjugates of therapeutic, agricultural, and food additive compounds
发明人：KONRADI ANDREI W; SMITH JENIFER L
权利人:KONRADI ANDREI W; SMITH JENIFER L; ELAN PHARM INC
摘要:This invention provides an improved synthesis of polymer conjugates of formula (I), n nof agricultural, therapeutic, and food additive compounds. In particular, a process is described for the preparation of conjugates by treating primary or secondary alcohol substituents of active compounds with polymeric nucleophiles using “Mitsunobuâ€? or related reaction conditions.

专利号:US-6531470-B1
优先权日:1998-01-23
标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:US-6562844-B2
优先权日:1998-01-23
标 题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:CN-113355367-B
优先权日:2018-03-22
标题 :Application of ketoacid reductase in synthesis of chiral aromatic 2-hydroxy acid

专利号:US-9217012-B2
优先权日:2009-04-08
标题 :Inhibitors of protein tyrosine phosphatases
发明人：ZHANG ZHONG-YIN; ZHANG SHENG
权利人:ZHANG ZHONG-YIN; ZHANG SHENG; UNIV INDIANA RES & TECH CORP
摘要:Disclosed herein are compounds that selectively inhibit members of the PTP family of enzymes. Synthesized compounds demonstrated selective inhibition of TC-PTP. Also provided are methods of using the compounds and formulations containing the compounds. Also described is a fluorescence-tagged combinatorial library synthesis and screening method. And methods of using these compounds to effect enzyme activity both in cells and in vitro as well as method of using these compounds to treat diseases in human and animals.

专利号:CN-108410831-B
优先权日:2018-03-22
标题:Ketoacid reductase, gene, engineering bacterium and application in synthesis of chiral aromatic 2-hydroxy acid