CAS: 3715-31-9; 3-Methyl-2-Oxovaleric Acid (Sodium)

该化合物是甲酸的钠盐衍生物,该化合物一般是白色的,是白色的,可溶于水中,因为存在钠离子,可增加其水利慈善性;分子结构具有五碳链,其中含有一个甲基组和一个氯酮功能组,有助于其在生化过程中的再反应和潜在应用;作为钠,它经常用于各种生物化学和制药用途,包括作为有机合成的潜在中间体或代谢研究的试剂;该化合物可能表现出箱酸等碳酸的典型特性,并可以参与各种化学反应,包括酯化和脱腐蚀;应就处理和储存安全数据,如所有化学物质,与所有化学物质一样,与安全数据一起,以确保遵循适当的实验室做法.

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3715-29-5 51829-07-3 2483736-09-8

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    ✅ COA系统入驻 | 共享模式

    主要参考文献

    [参考文献]: A S Coitinho, Et Al. Pharmacological Evidence That Alpha-Ketoisovaleric Acid Induces Convulsions Through Gabaergic And Glutamatergic Mechanisms In Rats. Brain Res. 2001 Mar 9;894(1):68-73.
    [参考文献]: Angela M Sgaravatti, Et Al. Inhibition Of Brain Energy Metabolism By The Alpha-Keto Acids Accumulating In Maple Syrup Urine Disease. Biochim Biophys Acta. 2003 Nov 20;1639(3):232-8.
    [参考文献]: M Reis, Et Al. Chloride-Dependent Inhibition Of Vesicular Glutamate Uptake By Alpha-Keto Acids Accumulated In Maple Syrup Urine Disease. Biochim Biophys Acta. 2000 Jul 3;1475(2):114-8.
    [参考文献]: Michele Sugantino, Et Al. Mycobacterium Tuberculosis Ketopantoate Hydroxymethyltransferase: Tetrahydrofolate-Independent Hydroxymethyltransferase And Enolization Reactions With Alpha-Keto Acids. Biochemistry. 2003 Jan 14;42(1):191-9.
    [参考文献]: N H Mcclenaghan, Et Al. Metabolic And K(Atp) Channel-Independent Actions Of Keto Acid Initiators Of Insulin Secretion. Pancreas. 2000 Jan;20(1):38-46.

    合成参考文献


    参考文献:10.1186/s40170-024-00335-5
    摘要:Gotvaldová K, Špačková J, Novotný J, Baslarová K, Ježek P, Rossmeislová L, Gojda J, Smolková K. BCAA metabolism in pancreatic cancer affects lipid balance by regulating fatty acid import into mitochondria. Cancer Metab. 2024 Mar 26;12(1):10.
    参考文献:10.1007/s00216-024-05613-1
    摘要:Engelhardt A, Ebeling M, Kaltenegger E, Langel D, Ober D. An easy and sensitive assay for acetohydroxyacid synthases based on the simultaneous detection of substrates and products in a single step. Anal Bioanal Chem. 2024 Oct 23;416(29):7085–98. doi: 10.1007/s00216-024-05613-1.
    参考文献:10.1038/s42255-024-01150-4
    摘要:Xiao W, Shrimali N, Vigder N, Oldham WM, Clish CB, He H, Wong SJ, Wertheim BM, Arons E, Haigis MC, Leopold JA, Loscalzo J. Branched-chain α-ketoacids aerobically activate HIF1α signalling in vascular cells. Nat Metab. 2024 Oct 29;6(11):2138–56. doi: 10.1038/s42255-024-01150-4.
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