CAS: 3650-09-7; (4Ar,10As)-5,6-Dihydroxy-7-Isopropyl-1,1-Dimethyl-1,2,3,4,4A,9,10,10A-Octahydrophenanthrene-4A-Carboxylic Acid

上下游产品

CAS号67494-15-9 花柏酸 | CAS号5957-80-2 鼠尾草酚 | CAS号380429-82-3 carnosic acid q... | CAS号80225-53-2 迷迭香酚

花柏酸置于chloroacetyl Meta-Chlorobenzoyl Peroxide,Sodium Tetrahydroborate,Sodium Hydroxide体系中,用 二氯甲烷,甲醇,水 作为反应溶剂,化学反应 68.0H,以23.3 Mg的收率获得产物鼠尾草酸
参考文献:迷迭香中的鼠尾草酸和鼠尾草酚(抗氧化剂)由沙瓦拉(sawara)的主要成分哌啶酸合成.
标题:迷迭香中的鼠尾草酸和鼠尾草酚(抗氧化剂)由沙瓦拉(sawara)的主要成分哌啶酸合成.
摘要:鼠尾草酸(2)是迷迭香(rosmarinus Officinalis)中的一种主要抗氧化剂,它是由sawara(chamaecyparis Pisifera)的主要成分pisiferic Acid(1)合成的,其中苯酚使用间氯过氧化苯甲酸酯进行邻位氧化. Mcbpo),氯乙酰基间氯过氧化苯甲酰(camcbpo)或2-碘氧基苯甲酸(ibx).鼠尾草酚(3)是迷迭香中的另一种抗氧化剂,是由鼠尾草酸通过氧化银氧化而合成的.据报道,其对痤疮丙酸杆菌(atcc 6919)(最小抑菌浓度(mic)杯/毫升)和金黄色葡萄球菌me / Gm / Tc耐药(atcc 33592)(mic杯/毫升)的肌酸和鼠尾草酚均具有有效的抗菌活性.
DOI:10.1248/cpb.58.27

专利信息

专利号:US-6479549-B2
优先权日:2000-02-28
标 题:Carnosic acid derivatives for promoting synthesis of nerve growth factor
发明人：KOSAKA KUNIO; MIYAZAKI TOSHITSUGU; YOKOI TOSHIO
权利人:NAGASE & CO LTD
摘要:A novel carnosic acid derivative for promoting the synthesis of nerve growth factor (NGF), a composition comprising the carnosic acid derivative as an effective ingredient, as well as, a method of promoting the synthesis of NGF comprising administering an effective amount of the carnosic acid derivative as an effective ingredient to a subject requiring such promotion. The carnosic acid derivative, composition and method according to the present invention can safely and efficiently promote the production of NGF in the living body, without being accompanied by a side effect such as a loss of a quantitative balance of hormones in the living body.

专利号:US-8722852-B2
优先权日:2006-04-28
标 题 :Cosmetic composition for stimulating the synthesis of proteins of the basement membrane
发明人：ZIEGLER HUGO; IMFELD DOMINIK; STOCKLI MARTIN; HEIDL MARC
权利人:ZIEGLER HUGO; IMFELD DOMINIK; STOCKLI MARTIN; HEIDL MARC; DSM IP ASSETS BV
摘要:Cosmetic composition which can be applied topically, comprising at least one compound of the general formula (I) in which R 1 is H, C 1 -C 20 -alkyl, cycloalkyl or aryl-C 1 -C 4 -alkyl, n is 1-4, X is —O—, —NH— or —NR 2 — and R 2 H or C 1 -C 20 -alkyl; and at least one compound corresponding to the above formula (I) but in which XR 1 with X having the possible meaning of —NH— is the residue of an alpha-amino acid; use of these compounds and of the composition for stimulating the synthesis of the proteins of the basement membrane; and also both those compounds of the formula (I) in which X is —NR 2 — and both R 1 and R 2 are different from H, and the compounds corresponding to formula (I) but in which XR 1 with X having the possible meaning of —NH— is the residue of an alpha-amino acid, as such.

专利号:WO-2023207921-A1
优先权日:2022-04-25
标题 :Taxamairin analogs and methods of preparation and use thereof
发明人：LEE CHI SING; GE SIYUAN; ZHUANG ANDREW-GO
权利人:UNIV HONG KONG BAPTIST UNIV
摘要:Taxamairin analogs useful in the treatment of cancer, pharmaceutical compositions including the same, methods of use thereof, and methods of preparation are provided. An efficient and scalable semi-synthesis of taxamairin compounds and analogs thereof from readily available commercial starting materials is provided. The synthesis involves low cost and relatively non-toxic reagents and is capable of synthesizing taxamairin A and taxamairin B and analogs thereof on multi-gram scale in yields up 12%and 21%, respectively.

专利号:US-2012094919-A1
优先权日:2009-03-16
标题 :Use of tripeptides
发明人：GRAEUB REMO; HEIDL MARC; IMFELD DOMINIK; MUELLER EIKE; WIKSTROEM PETER; ZIEGLER HUGO
权利人:GRAEUB REMO; HEIDL MARC; IMFELD DOMINIK; MUELLER EIKE; WIKSTROEM PETER; ZIEGLER HUGO
摘要:The present invention relates to the use of tripeptide derivatives for tightening, firming and/or moisturizing skin. Furthermore, the invention relates to a method for stimulating the synthesis of glycosaminoglycans containing a D-glucosamine and/or N-acetyl-D-glucosamine residue and/or proteoglycans by fibroblasts and/or keratinocytes such as in particular the synthesis of Hyaluronic acid and/or of the proteoglycans Decorin and/or Lumican.

专利号:EP-1382327-A1
优先权日:2002-07-17
标 题 :Method of protection of the skin against ageing
发明人：DANOUX LOUIS; FREIS OLGA; PAULY GILLES
权利人:COGNIS FRANCE SA
摘要:A method for the production of means for the stimulation of human is proposednSkin cells as well as to protect against skin aging and damaging influencesnEnvironmental toxins and UV radiation, characterized in that the means at least onenSubstance containing the synthesis of energy donors of the mitochondrial respiratory chainnincreases while at the same time the rate of reactive oxygen species (ROS) innCell metabolism lowers.n n n Furthermore, the use of cosmetic and / or pharmaceutical preparations,ncontaining at least one substance which the synthesis of energy donorsnthe mitochondrial respiratory chain increases while at the same time the rate of reactive oxygen speciesn(ROS) in cell metabolism, to stimulate human skin cellsnas well as to the protection against skin aging and damaging influences by environmental poisons andnUV radiation proposed.

专利号:US-11612556-B2
优先权日:2014-12-16
标 题:Peptidic compounds, compositions comprising them and uses of said compounds, in particular cosmetic uses
发明人：PESCHARD OLIVIER; DOUCET ANNE; LEROUX RICHARD; MONDON PHILIPPE
权利人:SEDERMA SA
摘要:The peptidic compound comprises at least an aminoacid which is lysine, ornithine, diaminopropionic acid or diaminobutyric acid or a derivative of these aminoacids, on which a carboxylic acid is grafted via a peptidic bound on the nitrogen of the lateral chain, said carboxylic acid comprising a (poly)cycle or (poly)heterocycle. Preferably, the grafted carboxylic acid is an aminoacid or a derivative, in particular selected from, a proline, a hydroxyproline or pyroglutamic acid.The peptidic compound can stimulate the synthesis of the main molecules constituting the extracellular matrix of the skin, especially collagen 1 and 4 and elastin. It can be used for topical cosmetic treatment such as a global anti-aging treatment, or for specific activities, including anti-wrinkles, moisturizing, to improve the mechanical properties of the skin, firmness/tone/elasticity/flexibility, to increase density and volume of the skin, improve skin radiance, for a restructuring effect and/or to fight stretch marks.