CAS: 3329-91-7; 4',5-Dimethyl-5-Azaspiro[bicyclo[2.2.2]Octane-2,2'-Pyran]-6'(3'H)-One
- 英文名称4',5-Dimethyl-5-Azaspiro[bicyclo[2.2.2]Octane-2,2'-Pyran]-6'(3'H)-One
- 中文名称4',5-二甲基-5-氮杂螺[.[2.2.2]辛烷-2,2'-吡喃]-6'(3'H)-酮
- IUPAC名称4',5-dimethyl-5-azaspiro[bicyclo[2.2.2]octane-2,2'-pyran]-6'(3'H)-one
- 其它别名(1R,4R,5R)-2,4'-Dimethylspiro[2-Azabicyclo[2.2.2]Octane-5,2'-[2H]Pyran]-6'(3'H)-One; Spiro[2-Azabicyclo[2.2.2]Octane-5,2'-[2H]Pyran]- 6'(3'H)-One,2,4'-Dimethyl-,(1R,4R,5S); Spiro[2-Azabicyclo[2.2.2]Octane-5,2'-[2H]Pyran]-6'(3'H)-One, 2,4'-Dimethyl-, (1R,2'S,4R)-
- CAS编号3329-91-7
- FDA UNII编号:Q4HFK9JJ1M
- 分子式:C13H19NO2分子量:221.3
- 产品CID: 2237870
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专利信息
专利号:US-6875774-B2
优先权日:2002-08-06
标题:Aza-bridged bicyclic amine derivatives for use as novel cholinergic receptor ligands
发明人：KOHN HAROLD; HARDEN T KENDALL; KIM MYOUNG GOO; BODOR ERIK
权利人:UNIV NORTH CAROLINA
摘要:The present invention discloses novel cholinergic receptor ligands. The present invention also relates to the synthesis of substituted derivatives of aza-bridged bicyclic amines for use as muscarinic receptor ligands as well as methods of regulating function of certain cholinergic receptors, and hence acting as antagonists, agonists and partial agonists at certain specific cholinergic receptor subtypes. The present invention also relates to methods for treating disorders associated with cholinergic receptors.
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主要参考文献
1: BROADBENT JL, SCHNIEDEN H. A comparison of some pharmacological properties of dioscorine and dioscine. Br J Pharmacol Chemother. 1958 Sep;13(3):213-5. doi: 10.1111/j.1476-5381.1958.tb00893.x.
2: Jittmittraphap A, Leaungwutiwong P, Meechokedee P, Chattanadee S, Thippornchai N, Sureram S, Mahidol C, Ruchirawat S, Kittakoop P. Virucidal activity of tiliacorinine, dioscorine, racemosol, and terrein against influenza A virus (H1N1), coronavirus 229E, SARS-CoV-2, and enterovirus 71. J Infect Public Health. 2025 Apr;18(4):102699. doi: 10.1016/j.jiph.2025.102699. Epub 2025 Feb 11. 22(1):e202401408. doi: 10.1002/cbdv.202401408. Epub 2024 Oct 31. 99(2):648-50. doi: 10.1021/ja00444a075. 15(11):3919-25. doi: 10.1016/j.bmc.2006.11.024. Epub 2006 Nov 16. 60(3):129-35. doi: 10.1007/s11130-005-6841-1. 49(10):4956-60. doi: 10.1021/jf010606m. 13(5):e70179. doi: 10.1002/fsn3.70179.
9: Abiodun OA, Akinoso R. Effect of delayed harvesting and pre-treatment methods on the antinutritional contents of trifoliate yam flour. Food Chem. 2014 Mar 1;146:515-20. doi: 10.1016/j.foodchem.2013.09.098. Epub 2013 Sep 24. 17(1):141-5. doi: 10.3923/pjbs.2014.141.145.
合成参考文献
摘要:British Journal of Pharmacology and Chemotherapy., 13(213), 1958 []
摘要:Ford - Ford MD, Delaney KA, Ling LJ, Erickson T (eds). Clinical Toxicology. Philadelphia: W.B. Saunders, 2001., p. 156
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