CAS: 26473-47-2; 3-Mercapto-2-Methylpropanoic Acid

上下游产品

CAS号79-41-4 甲基丙烯酸 | CAS号16674-04-7 3-氯-2-甲基丙酸 | CAS号7440-66-6 锌标准溶液 | CAS号80750-11-4 Ethyl 3-mercapt... | CAS号7732-18-5 水 | CAS号97-63-2 甲基丙烯酸乙酯 | CAS号33325-40-5 3-乙酰硫基-2-甲基丙酸 | CAS号637-51-4 N-Phenylthiofor... | CAS号80-62-6 甲基丙烯酸甲酯 | CAS号76497-39-7 D-3-乙酰巯基-2-甲基丙酸 | CAS号74431-52-0 D-(-)-S-ACETYL-... | CAS号77711-01-4 3-chlorosulfiny... | CAS号62574-23-6 2-甲基-3-(甲基磺酰基)丙酸 | CAS号62662-99-1 2-methyl-3-sulf...

📜甲基丙烯酸置于盐酸,硫脲体系中,用 水 用作溶剂,化学反应 2.5H,以16%的收率获得3-巯基异丁酸
参考文献:通过内酰胺的扩环合成大环和中型环硫内酯
标题:通过内酰胺的扩环合成大环和中型环硫内酯
摘要:据报道,有一种侧链插入方法可将内酰胺环扩大成大环硫内酯,也可纳入连续环扩大(sure)序列中.该反应在热力学上不如类似的内酰胺和内酯形成环扩展过程(这一观点得到dft数据的支持)低,但是尽管如此,已经开发了三种互补的保护基策略来实现这一具有挑战性的转化.
Doi:10.1039/d0Ob02502J

专利信息

专利号:US-6159352-A
优先权日:1996-05-07
标 题 :Process for the electrochemical synthesis of N-acetylcysteine from cystine
发明人：RIERA ANTONIO ALDAZ; LEGUEY VICENTE MONTIEL; GARCIA VICENTE GARCIA; GARCIA JOSEGONZALEZ
权利人:UNIV ALICANTE
摘要:The process comprises: (A) obtainment of N-acetyl-cysteine from L-cystine, by means of the following steps: n (i) acetylation of L-cystine to produce N-acetyl-cystine; n (ii) electroreduction and desalination by electrodialysis of the N-acetyl-cystine thus produced to give N-acetyl-cysteine; or (B) obtainment of N-acetyl-cysteine from L-cystine, by means of the following steps: n (i) acetylation and desalination of L-cystine to produce N-acetyl-cystine; n (ii) electroreduction of N-acetyl-cystine which may or may not come from the preceding step (i) to produce N-acetyl-cysteine; (C) obtainment of N-acetyl-cysteine from L-cystine by means of the following steps: n (i) electroreduction of L-cystine to produce L-cysteine; n (ii) acetylation and desalination by electrodialysis of L-cysteine, which may or may not come from the preceding step (i) to produce N-acetyl-cysteine. n The N-acetyl-cysteine thus obtained has important uses in the pharmaceutical sector.

专利号:US-7390801-B2
优先权日:1996-12-23
标题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
发明人：THORSETT EUGENE D; PLEISS MICHAEL A; LATIMER LEE H; JOHN VARGHESE; FREEDMAN STEPHEN; BRITTON THOMAS C; AUDIA JAMES A; REEL JON K; DRESSMAN BRUCE A; DROSTE JAMES J; HENRY STEVEN S; STUCKY RUSSELL D; PORTER WARREN J
权利人:ATHENA NEUROSCIENCES INC; LILLY CO ELI
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:US-10730899-B2
优先权日:2013-06-14
标 题 :Lipid-based platinum compounds and nanoparticles
发明人：SENGUPTA SHILADITYA; ROY MONIDEEPA; SARKAR ARINDAM; HOSSAIN SK SAMAD; SENGUPTA ANIRUDDHA; DUTTA PRADIP; ANSARI AASIF
权利人:AKAMARA THERAPEUTICS INC
摘要:The present disclosure is in relation to the field of nanotechnology and cancer therapeutics. In particular, the present disclosure relates to platinum based compounds comprising platinum moiety, linker moiety and lipid moiety and corresponding nanoparticles thereof. The disclosure further relates to synthesis of said platinum based compounds, nanoparticles and compositions comprising said platinum based compounds/nanoparticles. The disclosure also relates to methods of managing cancer by employing aforesaid carbene compounds, platinum based compounds, nanoparticles and compositions thereof.

专利号:WO-0116162-A1
优先权日:1999-08-28
标 题 :Method for producing cyclic peptidomimetics
发明人：SCHARN DIRK; GERMEROTH LOTHAR; WENSCHUH HOLGER
权利人:CHEMOTOPIX GMBH; SCHARN DIRK; GERMEROTH LOTHAR; WENSCHUH HOLGER
摘要:The invention relates to a method for the synthesis of cyclic peptides or peptidomimetics by means of sequential nucleophile substitutions on polyhalogenated aromatics. The method comprises the following steps: (i) A linear peptide or peptidomimetic with a free nucleophile functionality is reacted with the aromatic in the sense of a simple nucleophile aromatic substitution, whereby the nucleophile functionality is an alcohol, thiol or amine. (ii) The protective group of an additional nucleophile functionality is selectively split at the same peptide or peptidomimetic, whereby the released nucleophile functionality is an alcohol, thiol or amine and (iii) cyclisation is carried out by adding a tertiary amine or another base, whereby cyclisation is carried out by means of nucleophile aromatic substitution of an additional halogen atom of the halogen aromatic by the released nucleophile functionality, said halogen aromatic being bound to the peptide.

专利号:US-4533747-A
优先权日:1983-03-07
标 题:Leukotriene antagonists intermediates
发明人：GLEASON JOHN G; HALL RALPH F; KU THOMAS W
权利人:SMITHKLINE BECKMAN CORP
摘要:The compounds represented by the formula (I) (I) wherein m is 0, 1 or 2; p is 9, 10, 11, 12 or 13; R1' is hydrogen, and R2' is amino, -NHCH2CO2R3', -NHCH2CONH2 or -OR3' wherein R3' is an alkyl radical containing one to six carbon atoms with the proviso that when m is 0, R1' is hydrogen are chemical intermediates in the synthesis of leukotriene antagonists of the formula (II) (II) wherein m and p, are described above and R1 is hydrogen, amino or R2 is hydroxyl, amino, -NHCH2CO2H, -NHCH2CONH2; and X is -CO2H or -CH2OH which are useful in the treatment of diseases in which leukotrienes are a factor, such as asthma.

专利号:EP-0697401-B1
优先权日:1994-08-19
标 题 :Synthesis of mercaptocarboxylic acid esters