CAS: 24623-20-9; 6-Methyl-1-Indanone

该化合物是一种带有分子式C10H10O的圆锥酮,其特点是在因丹诺骨架的6个位置上有一个甲基组,该化合物是有机合成的多用途中间体,特别是在准备药品,香料和精细化学品方面,其硬性双环结构和反应性碳基组为构建复杂的分子框架提供了价值.甲基替代提高了其在再生选择性反应中的效用,提供了受控的功能化.在高纯度和稳定性的情况下,6-甲基乙基-1-Indanone适合要求的合成应用,包括不对称的催化和循环形成.其一贯的性能和特性确保了研究和工业过程的可靠性.

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合成工艺路线路线简述

    4-Methylcinnamic Acid置于palladium On Activated Charcoal 三氯化铝,氯化亚砜,氢气体系中,用 二硫化碳,乙醇 用作溶剂,5.0 °C,101.33 Kpa 条件下,反应 5.67H,反应生成6-甲基-1-茚酮
    参考文献:Collins,Michael J.; Gready,Jill E.; Sternhell,Sever,Australian Journal Of Chemistry,1990,Vol. 43,P. 1547-1557
    标题:Collins,Michael J.; Gready,Jill E.; Sternhell,Sever,Australian Journal Of Chemistry,1990,Vol. 43,P. 1547-1557

    海关参考信息

    专利信息


    专利号:WO-2023122754-A1
    优先权日:2021-12-23
    标 题 :Processes and intermediates for preparing gb13, gb22 and himgaline
    发明人:LANDWEHR ELEANOR; SHENVI RYAN; BAKER MEGHAN; OGUMA TAKUYA
    权利人:SCRIPPS RESEARCH INST
    摘要:Provided herein are processes for the streamlined synthesis of Galbulimima alkaloids, such as himbadine, isolated from Galbulimima belgraveana and G. baccatta, trees endemic to the rainforests of Northern Australia and Papua New Guinea, as well as analogs thereof, such as GB13, GB16, GB22, and himgaline, and further including intermediates useful in the synthesis of these and related compounds.

    专利号:US-6316437-B1
    优先权日:1999-09-30
    标题:Spirohydantoin compounds and uses thereof
    发明人:HOFFMAN JACOB M
    权利人:MERCK & CO INC
    摘要:Spirohydantoin compounds and their pharmaceutically acceptable salts are disclosed. The synthesis of these compounds and their use as alpha 1a adrenergic receptor antagonists is also described. One application of these compounds is in the treatment of benign prostatic hyperplasia. These compounds are typically selective in their ability to relax smooth muscle tissue enriched in the alpha 1a receptor subtype without at the same time inducing hypotension. One such tissue is found surrounding the urethral lining. Therefore, one utility of the instant compounds is to provide acute relief to males suffering from benign prostatic hyperplasia, by permitting less hindered urine flow. Another utility of the instant compounds is provided by combination with a human 5-alpha reductase inhibitory compound, such that both acute and chronic relief from the effects of benign prostatic hyperplasia can be achieved.

    专利号:US-2023002426-A1
    优先权日:2019-11-15
    标题 :Chiral synthesis of a tertiary alcohol

    专利号:US-2013267712-A1
    优先权日:2012-04-02
    标题 :Aromatic ketone synthesis with amide reagents and related reactions
    发明人:KLUMPP DOUGLAS A; RAJA ERUM K
    权利人:KLUMPP DOUGLAS A; RAJA ERUM K; UNIV NORTHERN ILLINOIS
    摘要:A method of preparing an aryl carbonyl or aryl thiocarbonyl compound, comprises reacting an N-(nitroaryl)-amide or N-(nitroaryl)-thioamide with an aromatic ring, with a superacid catalyst, to produce the aryl carbonyl or aryl thiocarbonyl compound. The superacid is present in an amount of at most 8 equivalents in proportion to the N-(nitroaryl)-amide or N-(nitroaryl)-thioamide. A method of preparing aryl amide or aryl thioamide, comprises reacting an N-(nitroaryl)-carbamide or N-(nitroaryl)-thiocarbamide with an aromatic ring, with a superacid catalyst, to produce the aryl amide or aryl thioamide.

    专利号:WO-2021097139-A1
    优先权日:2019-11-15
    标 题 :Chiral synthesis of a tertiary alcohol

    专利号:WO-9845272-A1
    优先权日:1997-04-07
    标题:Topoisomerase inhibitors
    发明人:DEADY LESLIE WILLIAM; DENNY WILLIAM ALEXANDER; KAYE ANTHONY JAMES
    权利人:UNIV LATROBE; DEADY LESLIE WILLIAM; DENNY WILLIAM ALEXANDER; KAYE ANTHONY JAMES
    摘要:The invention provides a novel series of tetracyclic quinoline and quinoxaline carboxamides, bis compounds in which two of the tetracyclic compounds are joined by a linker, and pharmaceutically-acceptable salts and N-oxides thereof, which have the ability to inhibit topoisomerase activity. The compounds are active in vitro and in vivo against tumour cells. Methods of synthesis and pharmaceutical compositions are also claimed.
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    主要参考文献

    参考标题:Cu-Catalyzed Coupling Of Indanone Oxime Acetates With Thiols To 2,3-Difunctionalized Indenones
    作者:Yuanyuan Fu,Xueyan Zhao,Dengfeng Chen,Jinyue Luo,Shenlin Huang
    摘要:A Cu-Catalyzed Coupling Reaction Of Indanone Oxime Acetates With Thiols Has Been Developed For The Synthesis Of 2,3-Functionalized 1-Indenones. This Protocol Has Several Features Including Easy Mild Reaction Conditions, Stabilized Enamine Products, Good Tolerance Of Functional Groups, And No External Oxidants. This Reaction Enables Direct Derivatization On The Indanone Ring To Provide Valuable Functionalized

    合成参考文献


    摘要:Merino, P., Science of Synthesis, (2010) 45, 289.
    摘要:Zimmer, R.; Trawny, D., Science of Synthesis Knowledge Updates, (2013) 4, 175.
    摘要:Elie, M.; Renaud, J.-L.; Gaillard, S., Science of Synthesis: N-Heterocyclic Carbenes in Catalytic Organic Synthesis, (2016) 1, 205.
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