CAS: 2095-03-6; Bisphenol F Diglycidyl Ether, Mixture Of Isomers

该化合物是一种环氧化合物,其特点是与中甲烷桥相连的两个甘菊酯功能组.该结构具有重要的反应性,使它在环氧树脂合成中成为有价值的中间体.该化合物一般在室内温度下是无色的,黄色的,在黄色固体上是无色的,具有良好的热稳定性和机械性能.它存在于各种有机溶剂中,包括丙酮和乙乙乙酸,但一般在水中是溶解的.DGEBA以其极好的粘性,化学抗药性和电绝缘性而著名,因此适合涂层,粘合剂和复合材料的应用.此外,如果用硬化剂治愈,它可形成可增强耐性和性能的交叉联系网络.在处理该化合物时,应注意安全防范措施,因为它可能会刺激皮肤和眼睛,并建议使用适当的个人防护设备.

结构式图片

上下游产品

bis-(4-hydroxyphenyl)methane epichlorohydrin

合成工艺路线路线简述

  • 合成目标产物 Bisphenol F Diglycidyl Ether 主要起始原料 4,4'-Dihydroxydiphenylmethane And Epichlorohydrin
  • (文献来源)合成步骤主要原料 4,4'-Dihydroxydiphenylmethane 和 Epichlorohydrin
对羟基苯甲醇置于sodium Hydroxide,Ytterbium(III) Triflate体系中,用 乙腈 用作溶剂,化学反应生成双酚f二缩水甘油醚
参考文献:β-受体阻滞剂富马酸比索洛尔相关化合物的合成与表征
标题:β-受体阻滞剂富马酸比索洛尔相关化合物的合成与表征
摘要:比索洛尔是一种用于治疗高血压的β受体阻滞剂.在比索洛尔的合成和放大过程中,会产生几种相关化合物.在本文中,我们公开了比索洛尔五种相关化合物的化学合成方法,即 3,3'-((亚甲基双(4,1-亚苯基))双(氧基))双(1-(异丙氨基) ) 丙-2-醇) (2),(比索洛尔 Ph.Eur 杂质-C),3,3'-(((氧基双(亚甲基))双(4,1-亚苯基))双(氧基))双( 1-(异丙氨基)丙-2-醇) (3),(比索洛尔 Ph.Eur 杂质-D),(+/-) 2-(4-((2-异丙氧基乙氧基)甲基)苯氧基)-3-(异丙氨基) Propan-1-Ol (4),(比索洛尔 Ph.Eur 杂质-F),(+/-) 4-((3-异丙基-2-氧代恶唑烷-5-基)甲氧基)苯甲醛 (17) (比索洛尔 Ph.Eur 杂质)-T),(+/-)5-((4-(羟甲基)苯氧基)甲基)-3-异丙基恶唑烷-2-酮(18)(比索洛尔ph
Doi:10.1007/s11696-023-03118-2

海关参考信息

专利信息


专利号:US-2023348657-A1
优先权日:2020-07-23
标题 :Synthesis of linear polyoxazolidinones using uretdiones as diisocyanate component
发明人:QUELL AGGELIKI; THOMAS HANS-JOSEF; ELING BEREND
权利人:BASF SE
摘要:A process for preparing a thermoplastic polymer involves reacting at least components (a) to (b), in the presence of a catalyst composition (c). Component (a) is an isocyanate composition containing at least one uretdione diisocyanate (a-i), and component (b) is an epoxide composition containing at least one diepoxide (b-i). The catalyst composition (c) contains at least one ionic liquid (c-i), preferably selected from 1-ethyl-3-methyl imidazolium bromide, 1-benzyl-3-methyl imidazolium chloride. 1-butyl-1-methylpiperidinium chloride, 1-ethyl-2,3-dimethylimidazolium bromide, 1-(2-hydroxyethyl)-3-methyl imidazolium chloride, butyl-1-methylpiperidinium acetate, or mixtures of two or more thereof. A thermoplastic polymer obtained or obtainable from the process is useful for the preparation of a fibre or a molded article or as a modifier for another thermoplastic material.

专利号:EP-4574877-A1
优先权日:2023-12-19
标题:Synthesis of activated vitrimer anhydride epoxy resin
发明人:MORETTO ENZO; PILUSO PIERRE
权利人:COMMISSARIAT ENERGIE ATOMIQUE
摘要:A method of manufacturing an activated vitrimer epoxy anhydride resin, intended for the reshaping of composite material parts comprising an epoxy anhydride resin and glass fibers, the manufacturing method comprising the following steps: - a) preparation of a solution from a mixture of three precursor components comprising a polyanhydride, an aminoalcohol, a polyepoxy and a solvent, - b) stirring the solution, - c) evaporation of the solvent so as to obtain a precursor mixture of the activated epoxy-vitrimer anhydride resin, and - d) crosslinking by applying a heat treatment so as to obtain the activated vitrimer epoxy anhydride resin.

专利号:US-11326018-B2
优先权日:2016-08-19
标 题:Process for the synthesis of polyoxazolidinone compounds
发明人:WEBER ANNA; RANGHEARD CLAUDINE; KESSLER MICHAEL; LEITNER WALTER; Gürtler Christoph; KOOPMANS CARSTEN; MÜLLER THOMAS ERNST
权利人:COVESTRO DEUTSCHLAND AG
摘要:A method for the production of polyoxazolidinone compounds, comprising the step of reacting an isocyanate compound (A) with an epoxide compound (B) in the presence of a catalyst (C), wherein the isocyanate compound (A) comprises a isocyanate compound (A 1 ) wherein the a isocyanate compound (A1) comprising at least two isocyanate groups (I 1 ≥2), preferred two isocyanate groups (I 1 =2), wherein the epoxide compound (B) comprises a epoxide compound (B 1 ) and an epoxide compound (B 2 ), wherein the epoxide compound (B 2 ) is different from the epoxide compound (B 1 ) wherein the epoxide compound (B 1 ) comprising at least two terminal epoxide groups (F1≥2), preferred two terminal epoxide groups (F 1 =2), linked together by a linking group (L1) and the epoxide compound (B 2 ) comprising at least two terminal epoxide groups (F 2 ≥2)), preferred two terminal epoxide groups (F 2 =2), linked together by a linking group (L 2 ), wherein the linking group (L 2 ) comprises acyclic and covalent bonds to each other free of conjugated multiple bonds within the main chain, wherein the epoxide compound (B 2 ) is present in the epoxide compounds B 1 and B 2 , in an amount of ≥0.01 mol-% to <10 mol-%, preferred 1-9 mol-% more preferred 3-8 mol-% based on the molar ratio the terminal epoxide groups in the epoxide compound (B 1 ) and of the sum of the terminal epoxide groups in the epoxide compound (B 1 ) and terminal epoxide groups in the epoxide compound (B 2 ).

专利号:US-11905228-B2
优先权日:2017-07-11
标 题 :Salts of diaminoacetals and diaminoketals and their synthesis, and their transformations to diaminoacetals and diaminoketals
发明人:KOSINSKI SZYMON; PASTINE STEFAN J; BHATT ULHAS
权利人:ADITYA BIRLA CHEMICALS USA INC
摘要:This application relates, in part, to novel salts represented by the following structure of Formula (1): n n n n n n n n n n wherein R 1a is selected from the group consisting of hydrogen and optionally substituted alkyl (e.g., unsubstituted C 1-6 alkyl, e.g., —CH 3 ); R 1b is optionally substituted alkyl (e.g., unsubstituted C 1-6 alkyl, e.g., —CH 3 ); each occurrence of R 2 and R 3 is independently selected from the group consisting of hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, and optionally substituted aryl; R 2 and R 3 can combine with each other to form optionally substituted cycloalkyl; each m and n is independently an integer ranging from 1 to 20 (e.g., m and n is independently an integer ranging from 1 to 5); and each of Q 1⊖ and Q 2⊖ is independently a counterion (e.g., each of Q 1⊖ and Q 2⊖ is independently a counterion selected from the group consisting of chloride, bromide, fluoride, iodide, acetate, carboxylate, hydrogen sulfate, nitrate, and phenolate, and sulfonate, e.g., chloride), and methods of making the same.

专利号:US-2008051323-A1
优先权日:2004-08-21
标 题 :Chloroquine drug compositions and methods for their synthesis
发明人:KOSAK KENNETH M
权利人:KOSAK KENNETH M
摘要:This invention discloses compositions of chloroquine-coupled active agents, including methods for their preparation. The prior art has shown that chloroquines given as free drug in high enough concentration, enhances the release of various agents from cellular endosomes into the cytoplasm. The purpose of these compositions is to provide a controlled amount of chloroquine at the same site where the active agent is delivered, thereby reducing the overall dosage needed. n The compositions comprise a chloroquine substance coupled to an active agent directly or through a variety of pharmaceutical carrier substances. The carrier substances include polysaccharides, synthetic polymers, proteins, micelles and other substances for carrying and releasing the chloroquine compositions in the body for therapeutic effect. The compositions can also include a biocleavable linkage for carrying and releasing active agents for therapeutic or other medical uses. The invention also discloses carrier compositions that are coupled to targeting molecules for targeting the delivery of chloroquine substances and active agents to their site of action.

专利号:US-2007060499-A1
优先权日:2005-09-15
标 题 :Chloroquine combination drugs and methods for their synthesis
发明人:KOSAK KENNETH M
权利人:KOSAK KENNETH M
摘要:This invention discloses compositions of chloroquine-coupled active agents, including methods for their preparation. The prior art has shown that chloroquines given as free drug in high enough concentration, enhances the release of various agents from cellular endosomes into the cytoplasm. The purpose of these compositions is to provide a controlled amount of chloroquine at the same site where the active agent is delivered, thereby reducing the overall dosage needed. The compositions comprise a chloroquine substance coupled to an active agent directly or through a variety of pharmaceutical carrier substances. The carrier substances include polysaccharides, synthetic polymers, proteins, micelles and other substances for carrying and releasing the chloroquine compositions in the body for therapeutic effect. The compositions can also include a biocleavable linkage for carrying and releasing active agents for therapeutic or other medical uses. The invention also discloses carrier compositions that are coupled to targeting molecules for targeting the delivery of chloroquine substances and active agents to their site of action.
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合成参考文献


摘要:S109 | PARCEDC | List of 7074 potential endocrine disrupting compounds (EDCs) by PARC T4.2 | DOI:10.5281/zenodo.10944198
参考文献:10.1007/s00204-006-0121-1
摘要:Ramilo G, Valverde I, Lago J, Vieites JM, Cabado AG. Cytotoxic effects of BADGE (bisphenol A diglycidyl ether) and BFDGE (bisphenol F diglycidyl ether) on Caco-2 cells in vitro. Arch Toxicol. 2006 Nov;80(11):748–55. doi: 10.1007/s00204-006-0121-1.
参考文献:10.1007/s00216-004-2744-5
摘要:San Vicente B, Navarro Villoslada F, Moreno-Bondi MC. Continuous solid-phase extraction and preconcentration of bisphenol A in aqueous samples using molecularly imprinted columns. Analytical and Bioanalytical Chemistry. 2004 Aug 13;380(1):115–22. doi: 10.1007/s00216-004-2744-5.
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