CAS: 1999-46-8; 2-(2-Aminopropanamido)-3-Methylbutanoic Acid

该化合物是一种由异丙胺和valine的种族形式构成的低脂,该化合物由于其结构多功能性,主要用于生化研究和peptide合成,其种族性质使得可以研究Peptide相互作用和酶特性中的立体化学效应.该产品是开发经修改的peptide和peptimimictics的宝贵中间体,提供了对相容稳定性和结合性的认识.其水溶液的溶解性便于实验室环境中的处理.DL-Alanyl-DL-valine还用于新陈代谢研究,以调查Peptide的迁移和降解路径.在标准条件下,Diptide的稳定性确保实验应用的可靠性能.

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上下游产品

N-(2-bromo-propionyl)-valineN-(2-bromo-propionyl)-valine ammonia D-Val-OH benzyloxycarbonyl-alanyl-valineN-(N-benzoyl-alanyl)-valineN-(N-benzoyl-alanyl)-valine (S)-2-{(S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-propionylamino}-3-methyl-butyric acid; compound with dicyclohexyl-amine TrpAlaValGlyHisLeuMetNH2

合成工艺路线路线简述

    📜N-(2-Bromo-Propionyl)-Valine置于氨体系中,化学反应生成Dl-丙氨酰基-Dl-缬氨酸
    参考文献:Fischer,E.; Scheibler,Justus Liebigs Annalen Der Chemie,1908,Vol. 363,P. 158,159
    标题:Fischer,E.; Scheibler,Justus Liebigs Annalen Der Chemie,1908,Vol. 363,P. 158,159

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    专利信息


    专利号:US-9751911-B2
    优先权日:2012-11-27
    标 题:Solomonamide analogue compounds, pharmaceuticals containing solomonamide analogue compounds, and processes for the preparation thereof
    发明人：REDDY DUMBALA SRINIVASA; KOMIRISHETTY KASHINATH; NATARAJAN VASUDEVAN
    权利人:COUNCIL SCIENT IND RES
    摘要:Solomanamide analogs of Formula-I having anti-inflammatory activity, and viable synthetic routes for the preparation of such analogs, including the synthesis of macrocyclic core of Salomanamide analogs. The Solomanamide analogs of Formula-I or their pharmaceutical salt may be provided in a pharmaceutical composition and administered in an effective amount for the treatment of inflammation and/or pain.

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    主要参考文献

    参考标题:Solomonamide Analogue Compounds, Pharmaceuticals Containing Solomonamide Analogue Compounds, And Processes For The Preparation Thereof
    摘要:Solomanamide Analogues Of Formula-I Having Anti-Inflammatory Activity, And Viable Synthetic Routes For The Preparation Of Such Analogues, Including The Synthesis Of Macrocyclic Core Of Salomanamide Analogues. The Solomanamide Analogues Of Formula-I Or Their Pharmaceutical Salt May Be Provided In A Pharmaceutical Composition And Administered In An Effective Amount For The Treatment Of Inflammation And/or Pain.

    合成参考文献


    参考文献:10.1134/s0036024423080071
    摘要:Gridchin SN, Nikolskii VM. Protolytic Equilibria of L-Alanyl-L-histidine in Aqueous Solutions. Russ. J. Phys. Chem. 2023 Aug;97(8):1692–9. doi: 10.1134/s0036024423080071.
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