CAS: 181269-69-2; Tert-Butyl 3-Methyl-4-Oxopiperidine-1-Carboxylate

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CAS号34737-89-8 1-苄基-3-甲基-4-哌啶酮 | CAS号24424-99-5 二碳酸二叔丁酯 | CAS号79099-07-3 1-B°C-4-哌啶酮 | CAS号74-88-4 碘甲烷 | CAS号5773-58-0 3-甲基-4-哌啶 | CAS号1159982-52-1 1-tert-butyl 3-... | CAS号33557-57-2 4-羟基-3-甲基哌啶 | CAS号5773-58-0 3-甲基-4-哌啶 | CAS号4629-78-1 3-甲基哌啶-4-酮盐酸盐 | CAS号181269-70-5 N-B°C-3-甲基-4-羟基哌啶 | CAS号13299-58-6 1,2,3,6-四氢-3-甲基... | CAS号373604-48-9 4-Methoxy-3-met...

📜(E)-Tert-Butyl 3-((Dimethylamino)Methylene)-4-Oxopiperidine-1-Carboxylate置于palladium 10% On Activated Carbon,氢气体系中,用 丙酮 用作溶剂,化学反应 48.0H,以84%的收率获得3-甲基-4-氧代哌啶-1-羧酸叔丁酯
参考文献:酮的选择性 α-甲基化
标题:酮的选择性 α-甲基化
摘要:描述了用于酮的两步 α-甲基化的方便且可扩展的制备方法.开发了区域选择性制备烯胺酮的优化方案,具有进一步的非对映选择性和官能团耐受氢化成 α-甲基酮.讨论了所提议方法的范围和局限性.证明了与已知程序相比的优点.暗示了丙酮在氢化中的意想不到的作用.显示了对早期构建块合成和后期 Ch 功能化方法的评估.复杂程序的可制备性和可扩展性通过合成高达 100 G 的几种 α-甲基酮来证明.
Doi:10.1021/acs.Joc.1C00148

专利信息

专利号:US-2024400552-A1
优先权日:2016-11-11
标题 :Heterocyclic modulators of lipid synthesis
发明人：BUCKLEY DOUGLAS I; DUKE GREGORY; WAGMAN ALLAN S; EVANCHIK MARC; MCDOWELL ROBERT S
权利人:SAGIMET BIOSCIENCES INC
摘要:Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by dysregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders, such as non-alcoholic steatohepatitis (NASH).

专利号:US-11622968-B2
优先权日:2011-03-08
标 题:Heterocyclic modulators of lipid synthesis
发明人：BUCKLEY DOUGLAS; DUKE GREGORY; WAGMAN ALLAN S; EVANCHIK MARC; MCDOWELL ROBERT S
权利人:SAGIMET BIOSCIENCES INC
摘要:Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by disregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders, such as non-alcoholic steatohepatitis (NASH).

专利号:US-11034690-B2
优先权日:2016-11-11
标 题:Heterocyclic modulators of lipid synthesis
发明人：BUCKLEY DOUGLAS I; DUKE GREGORY; WAGMAN ALLAN S; EVANCHIK MARC; MCDOWELL ROBERT S
权利人:SAGIMET BIOSCIENCES INC; SAGINIET BIOSCIENCES INC
摘要:Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by disregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders, such as non-alcoholic steatohepatitis (NASH).

专利号:US-9809591-B2
优先权日:2011-03-08
标题 :Heterocyclic modulators of lipid synthesis
发明人：OSLOB JOHAN D; MCDOWELL ROBERT S; JOHNSON RUSSELL; YANG HANBIAO; EVANCHIK MARC; ZAHARIA CRISTIANA A; CAI HAIYING; HU LILY W
权利人:3-V BIOSCIENCES INC
摘要:Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by disregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders.

专利号:US-2019308969-A1
优先权日:2016-11-11
标 题 :Heterocyclic modulators of lipid synthesis

专利号:US-2022296605-A1
优先权日:2011-03-08
标 题 :Heterocyclic modulators of lipid synthesis