CAS: 1687-53-2; 5-Amino-2-Methoxyphenol

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2-甲氧基-5-硝基苯酚置于硫酸,铁粉体系中,化学反应生成2-甲氧基-5-氨基苯酚
参考文献:Treatment Of Affective Disorder And Obesity With Topiramate
标题:Treatment Of Affective Disorder And Obesity With Topiramate
摘要:以下是您请求的翻译结果: 报告一例使用抗癫痫药物托吡酯治疗的患者的体重减轻和情绪稳定案例. 一位37岁的肥胖白人女性,情绪不稳定且肥胖,正在接受辅助托吡酯治疗.患者在接受托吡酯治疗的10周内体重减轻了10公斤,并且临床状况有所改善,这从她需要被送入管理单位进行持续观察的次数减少以及需要机械约束或药物干预的激烈爆发次数减少中得到证明.此外,在接受托吡酯治疗期间,患者成功完成了两次家庭访问,并且在撰写本文时,她正在进行第三次家庭访问,已经出院. 这个案例进一步强化了之前的报告,即托吡酯可能有助于治疗情感障碍以及在体重增加常见的人群中诱导体重减轻.本案例报告中的患者没有急性疾病或健康状况的变化,饮食没有变化,也没有药物变化,这些都不可能导致突然的体重减轻.此外,患者的行为在足疗程的试验期间,将托吡酯作为辅助治疗加入丙戊酸,西酞普兰和氯丙嗪后才有改善. 需要进行控制研究,以评估托吡酯在精神病患者中的使用,特别是对于额外诊断为肥胖的精神病患者,托吡酯治疗的益处.
Doi:10.1345/aph.10027

专利信息

专利号:US-7550510-B2
优先权日:2001-07-06
标 题 :Solid phase synthesis of arylretinamides
发明人：CURLEY JR ROBERT W; MERSHON SERENA M; BARNETT DEREK W; CLAGETT-DAME MARGARET; CHAPMAN JASON S
权利人:WISCONSIN ALUMNI RES FOUND
摘要:A solid phase synthetic method for preparing arylretinamides is provided. The method comprises reacting hexachloroacetone with a solvent-suspended resin-bound triphenylphosphine to provide a suspension comprising an activated chlorinating reagent; reacting retinoic acid with the activated chlorinating reagent to provide retinoyl chloride; adding pyridine and a select arylamine to the resulting mixture; and stirring the resulting mixture for a time and at a temperature sufficient for the select arylamine to react with the retinoyl chloride and provide the arylretinamide. Also provided, are select arylretinamides that can be prepared by the present method, and methods of using such arylretinamides to induce apoptosis in cancer cells.

专利号:US-3832365-A
优先权日:1972-03-14
标 题 :Quinone intermediates for synthesis of 6-hydroxydopamine
发明人：WEHRLI P
权利人:HOFFMANN LA ROCHE
摘要:PREPARATION OF 6-HYDROXYDOPAMINE A KNOWN ANTIHYPERTENSIVE AND BLOOD PRESSURE LOWERING AGENT, FROM AN HYDROXY-ALKOXY-PHENETHYLAMINE INCLUDING INTERMEDIATES IN THIS PROCESS.

专利号:US-2004102650-A1
优先权日:2001-07-06
标 题:Solid phase synthesis of arylretinamides

专利号:US-2012016390-A1
优先权日:2010-07-16
标 题 :Bioadhesive compounds and methods of synthesis and use
发明人：LEE BRUCE P; MURPHY JOHN L; VOLLENWEIDER LAURA; DALSIN JEFFREY L; LYMAN ARINNE N
权利人:LEE BRUCE P; MURPHY JOHN L; VOLLENWEIDER LAURA; DALSIN JEFFREY L; LYMAN ARINNE N; KNC NER ACQUISITION SUB INC
摘要:The invention describes new synthetic medical adhesives and antifouling coatings which exploit the key components of natural marine mussel adhesive proteins.

专利号:US-9370515-B2
优先权日:2013-03-07
标题 :Mixed lineage kinase inhibitors and method of treatments
发明人：GOODFELLOW VAL S; NGUYEN THONG X; RAVULA SATHEESH B; GELBARD HARRIS A
权利人:CALIFIA BIO INC; UNIV ROCHESTER
摘要:Provided herein are imidazopyridine compounds having an inhibitory effect on mixed lineage kinases (MLKs), methods of their synthesis, and methods of their therapeutic. Also provided are pharmaceutical compositions comprising the compounds and methods of using the compounds and pharmaceutical compositions.

专利号:WO-2008104925-A1
优先权日:2007-02-27
标题 :Chromone derivatives for use as antioxidants/preservatives
发明人：MARTINS BORGES MARIA FERNANDA; NEVES GASPAR ALEXANDRA MARIA; PINTO DE JESUS GARRIDO JORGE M; DA SILVA PEREIRA MILHAZES NUNO; CANTEIRO BATOREU MARIA CAMILA
权利人:UNIV DO PORTO; MARTINS BORGES MARIA FERNANDA; NEVES GASPAR ALEXANDRA MARIA; PINTO DE JESUS GARRIDO JORGE M; DA SILVA PEREIRA MILHAZES NUNO; CANTEIRO BATOREU MARIA CAMILA
摘要:The current invention depicts the synthesis of new chromone amide derivatives placed at positions C2 and C3 of the chromone nucleus. The synthesised compounds possess the general formulas (I) and (II) as displayed below. This new compounds possessing different substitution patterns were obtained through a condensation reaction between 2- or 3 - carboxychromone and aniline (phenylamine) or its substituted derivatives in fairly good yields. The syntheses of the dihydroxylated compounds were performed by a demethylation reaction of the previously obtained monomethoxylated chromones. Some of these compounds possess a putative use as antioxidant/preservatives for pharmaceutical, cosmetic and/or food industries.