CAS: 1667-11-4; 4-(Chloromethyl)Biphenyl

相似化合物

1667-10-3 2567-29-5 14002-51-8

上下游产品

CAS号3597-91-9 4-联苯甲醇 | CAS号191097-22-0 2-(2-tert-butyl... | CAS号5728-52-9 联苯乙酸 | CAS号50-00-0 甲醛 | CAS号92-52-4 联苯 | CAS号644-08-6 4-甲基联苯 | CAS号3315-91-1 4-联苯基溴化镁 | CAS号7647-01-0 盐酸 | CAS号3597-91-9 4-联苯甲醇 | CAS号35888-99-4 3-(4-联苯基)丙酸 | CAS号3218-36-8 4-联苯甲醛 | CAS号31603-77-7 4-联苯乙腈 | CAS号63024-23-7 Dl-3-(4-联苯)丙氨酸盐酸盐 | CAS号5728-52-9 联苯乙酸 | CAS号13026-23-8 4-苯基肉桂酸 | CAS号30818-70-3 (4-联苯基甲基)磷酸二乙酯 | CAS号14062-23-8 联苯乙酸乙酯

4-联苯乙酸置于2,4,6-三甲基吡啶,N-氯代丁二酰亚胺,4,4'-二甲氧基-2,2'-联吡啶,Iron(II) Acetate体系中,用 乙腈 用作溶剂,以47 %的收率获得4-氯甲基联苯
参考文献:可见光下铁盐催化脂肪族羧酸的脱羧卤化
标题:可见光下铁盐催化脂肪族羧酸的脱羧卤化
摘要:在本文中,我们报告了可见光下铁盐催化脂肪族羧酸直接脱羧氯化,碘化和溴化的通用方案.该方法底物范围广泛,具有非常好的官能团兼容性,包括复杂的天然产物.苯甲基和烯丙基c(Sp 3 )-h键可以在氧化卤化条件下保留.该方法还显示出后期功能化的应用潜力.
Doi:10.1039/d3Cc06149C

专利信息

专利号:US-6639059-B1
优先权日:1999-03-24
标 题 :Synthesis of [2.2.1]bicyclo nucleosides
发明人：KOCHKINE ALEXEI; FENSHOLDT JEF; PFUNDHELLER HENRIK M
权利人:EXIQON AS
摘要:A synthesis of [2.2.1]bicyclo nucleosides which is shorter and provides higher overall yields proceeds via the key intermediate of the general formula III, wherein R4 and R5 are, for instance, sulfonates and R7 is, for instance, a halogen or an acetate. From compounds of the general formula II, such as 3-O-aryl-4-C-hydroxymethyl-1,2-O-isopropylidene-alpha-D-ribofuranose, intermediates of the general formula III are suitable for coupling with silylated nucleobases. Upon one-pot base-induced ring-closure and desulfonation of the formed [2.2.1]bicyclo nucleoside, a short route to each the LNA (Locked Nucleic Acid) derivatives of adenosine, cytosine, uridine, thymidine and guanidine is demonstrated. The use of the 5'-sulfonated ring-closed intermediate also allows for synthesis of 5'-amino- and thio-LNAs.

专利号:US-6734291-B2
优先权日:1999-03-24
标题:Synthesis of [2.2.1]bicyclo nucleosides
发明人：KOCHKINE ALEXEI; FENSHOLDT JEF; PFUNDHELLER HENRIK M
权利人:EXIQON AS
摘要:A synthesis of [2.2.1]bicyclo nucleosides which is shorter and provides higher overall yields proceeds via the key intermediate of the general formula III, wherein R4 and R5 are, for instance, sulfonates and R7 is, for instance, a halogen or an acetate. From compounds of the general formula II, such as 3-O-aryl-4-C-hydroxymethyl-1,2-O-isopropylidene-alpha-D-ribofuranose, intermediates of the general formula III are suitable for coupling with silylated nucleobases. Upon one-pot base-induced ring-closure and desulfonation of the formed [2.2.1]bicyclo nucleoside, a short route to each the LNA (Locked Nucleic Acid) derivatives of adenosine, cytosine, uridine, thymidine and guanidine is demonstrated. The use of the 5'-sulfonated ring-closed intermediate also allows for synthesis of 5'-amino- and thio-LNAs

专利号:EP-1953140-A1
优先权日:2007-01-24
标 题 :Process for the preparation of ezetimibe and derivatives thereof
发明人：STIMAC ANTON; MOHAR BARBARA; STEPHAN MICHEL; BEVC MOJCA; ZUPET ROK; GARTNER ANDREJ; KROSELJ VESNA; SMRKOLJ MATEJ
权利人:KRKA
摘要:The present invention relates to the method of preparing of ezetimibe and in particular to novel intermediates for its synthesis and an improved process for preparing such intermediates. Said intermediates may be obtained in high yields and purity in a fast and cost efficient manner. The present invention relates to a novel crystalline form of ezetimibe as well.

专利号:US-2003092905-A1
优先权日:1999-03-24
标 题:Synthesis of [2.2.1]bicyclo nucleosides

专利号:EP-1326851-B1
优先权日:2000-10-13
标 题 :Substituted dipeptides as growth hormone secretagogues
发明人：DODGE JEFFREY ALAN; EVERS BRITTA; JUNGHEIM LOUIS NICKOLAUS; MUEHL BRIAN STEPHEN; RUEHTER GERD; THRASHER KENNETH JEFF
权利人:LILLY CO ELI
摘要:This invention relates to novel compounds which are useful in the modulation of endogenous growth hormone levels in a mammal. The invention further relates to novel intermediates for usein the synthesis of said compounds, as well as novel processes employed in these syntheses. Also included are methods of treating a mammal which include the administration of said compounds.

专利号:US-5202444-A
优先权日:1990-11-27
标题:Optically isomeric inositol and process for making optically active compound
发明人：OZAKI SHOICHIRO; AKIYAMA TAKAHIKO; KAGEYAMA KUNIO; MACHIDA MORIHISA
权利人:YOKOHAMA RUBBER CO LTD
摘要:Optically active diols and hydroxycarboxylic acids and their esters are produced by deriving 1L-1,2:5,6-di-O-cyclohexylidene-chiro-inositol from 1L-chiro-inositol as an asymmetric source, followed by introduction of a selected class of sterically hindering and asymmetrically reactive groups into the first-mentioned compound and by subsequent reduction of the resulting compound. Seven specific inositols are also derivable from synthesis of those ultimate compounds.