CAS: 1530-32-1; Ethyltriphenylphosphonium Bromide

相似化合物

896-33-3 4736-60-1 6228-47-3

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溴乙烷,三苯基膦 以 甲苯 用作溶剂,化学反应 24.0H,以79%的收率获得乙基三苯基溴化膦
参考文献:所有鏻叶立德类型的统一锂无盐 Wittig 反应机制的明确实验证据:与 β-杂原子取代的醛的反应始终具有选择性 Forcis-Oxaphosphetane 衍生产品
标题:所有鏻叶立德类型的统一锂无盐 Wittig 反应机制的明确实验证据:与 β-杂原子取代的醛的反应始终具有选择性 Forcis-Oxaphosphetane 衍生产品
摘要:无锂盐维蒂希反应的真实过程长期以来一直是有机化学中一个有争议的问题.在此,我们报告了所有三种主要鏻叶立德类(非稳定化,半稳定化和稳定化)的 Wittig 反应所共有的实验效果:对顺式氧杂膦烷及其衍生产物(z-烯烃和赤型-β-羟基鏻盐)在涉及在 β 位带有杂原子取代基的醛的反应中.该效应对苯甲醛和脂肪族醛都起作用,并且显示在醛上没有杂原子取代基的情况下不起作用.所有叶立德类型反应共有效应的发现有力地证明了所有 Li 无盐 Wittig 反应的共同机制.此外,结果表明,由 Vedejs 和同事提出的 [2+2] 环加成机制最容易解释,并由 Aggarwal,Harvey 和同事补充,从而为支持该机制提供了强有力的确证证据.值得注意的是,在半稳定叶立德的情况下,邻位取代基的协同作用得到证实,并被环加成机制所适应.该效应也显示在三苯基膦衍生的叶立德的反应中起作用,并且先前已在水性条件下的反应中观
Doi:10.1021/ja300943Z

专利信息

专利号:US-2004018598-A1
优先权日:2000-05-30
标题 :Bio-intermediates for use in the chemical synthesis of polyketides
发明人：SANTI DANIEL; ASHLEY GARY; MYLES DAVID C
摘要:The present invention relates to compounds made by a subset of modules from one or more polyketide synthase (“PKSâ€?) genes that are used as starting material in the chemical synthesis of novel molecules, particularly naturally occurring polyketides or derivatives thereof. The biologically derived intermediates (“bio-intermediatesâ€?) generally represent particularly difficult compounds to synthesize using traditional chemical approaches due to one or more stereocenters. In one aspect of the invention, an intermediate in the synthesis of epothilone is provided that feeds into the synthetic protocol of Danishefsky and co-workers. In another aspect of the invention, intermediates in the synthesis of discodermolide are provided that feed into the synthetic protocol of Smith and co-workers. By taking advantage of the inherent stereochemical specificity of biological processes, the syntheses of key intermediates and thus the overall syntheses of compounds like epothilone and discodermolide are greaty simplified.

专利号:US-2008103312-A1
优先权日:2006-08-29
标 题:Processes for the synthesis of 5-phenyl-1-trityl-1H-tetrazole
发明人：KANSAL VINOD K; MISTRY DHIRENKUMAR N; VASOYA SANJAY L; LUNAGARIYA VIJAYKUMAR D
权利人:KANSAL VINOD K; MISTRY DHIRENKUMAR N; VASOYA SANJAY L; LUNAGARIYA VIJAYKUMAR D
摘要:Provided are processes for the synthesis of 5-phenyl-1-trityl-1H-tetrazole, an intermediate useful in the synthesis of irbesartan.

专利号:WO-9517903-A1
优先权日:1993-12-28
标 题:Modular design and synthesis of oxazolone-derived molecules
发明人：HOGAN JOSEPH C JR; CASEBIER DAVID; FURTH PAUL; TU CHENG
权利人:ARQULE PARTNERS L P; HOGAN JOSEPH C JR; CASEBIER DAVID; FURTH PAUL; TU CHENG
摘要:The design and synthesis of novel oxazolone-derived molecular modules and the use of the modules in the construction of new molecules and fabricated materials is disclosed. The new molecules and fabricated materials are molecular recognition agents useful in the design and synthesis of drugs, and have applications in separations and materials science.

专利号:US-6271379-B1
优先权日:2000-03-08
标题:Intermediates useful for the synthesis of huperzine A
发明人：TUECKMANTEL WERNER; KOZIKOWSKI ALAN P
权利人:UNIV GEORGETOWN
摘要:Intermediates useful for the synthesis of huperzine A represented by the structures below, n and methods for their synthesis, wherein: n R 1 is lower alkyl, benzyl, or substituted benzyl; n X is a suitable leaving group; n Y is an electron withdrawing group that can subsequently be converted into an amino group; n one broken line is present as a carbon—carbon bond and the other broken line is absent, where the broken line forms an unconjugated carbon—carbon double bond, which double bond may be endocyclic whereby n is 3 or the double bond may be exocyclic whereby n is 2.

专利号:US-4360470-A
优先权日:1980-10-22
标题 :Process and intermediates for the synthesis of Vitamin D3 metabolites and chenodeoxycholic acid
发明人：BATCHO ANDREW D; USKOKOVIC MILAN R; WOVKULICH PETER M
权利人:HOFFMANN LA ROCHE
摘要:The present disclosure is directed to a process for the synthesis of chenodeoxychloic acid, 25-hydroxycholesterol and 1α,25-dihydroxycholesterol from 17-keto steroids. A cholic acid side chain is stereospecifically introduced by reaction of the appropriate 17-keto steroid with ethyltriphenylphosphonium halides to produce the 17-ethylidene derivative which is allowed to react with acrylic acid esters or propiolic acid esters followed by hydrogenation.

专利号:US-4396542-A
优先权日:1980-02-14
标 题 :Method for the total synthesis of cyclosporins, novel cyclosporins and novel intermediates and methods for their production
发明人：WENGER ROLAND
权利人:SANDOZ LTD
摘要:A method for the total synthesis of cyclosporins, in particular Cyclosporin A, cyclosporins produced in accordance with the method of the invention and novel intermediates, in particular novel [1S, 2R, 3R]- and [1R, 2S, 3S]-1-nitrilo-1-carbonyl-3-methyl-2-oxy-heptanes and -hept-5-enes, employed in the method of the invention.