CAS: 137234-63-0; 2-(2,4-Difluorophenyl)-3-(5-Fluoro-4-Pyrimidinyl)-1-(1H-1,2,4-Triazol-1-yl)-2-Butanol

上下游产品

2-fluoro-3-oxopentanoic acid ethyl ester 6-Ethyl-5-fluoropyrimidin-4(3H)-one 4-chloro-6-ethyl-5-fluoropyrimidine 1-(4-chloro-5-fluoropyrimidin-6-yl)bromoethane 16H14F3N5O*C7H7NO2C16H14F3N5O*C7H7NO2 16H14F3N5O*C7H5NO4C16H14F3N5O*C7H5NO4

氟代丙酰基乙酸乙酯置于palladium On Activated Charcoal 甲醇,氢气,Sodium Methylate,Sodium Acetate,Lithium Diisopropyl Amide,三氯氧磷体系中,用 四氢呋喃,乙醇 用作溶剂,化学反应生成α-(2,4-二氟苯基)-5-氟-β-甲基-α-(1,2,4-三唑-1-甲基)-4-嘧啶乙醇
参考文献:Novel Antifungal 2-Aryl-1-(1H-1,2,4-Triazol-1-yl)Butan-2-Ol Derivatives With High Activity Against Aspergillus Fumigatus
标题:Novel Antifungal 2-Aryl-1-(1H-1,2,4-Triazol-1-yl)Butan-2-Ol Derivatives With High Activity Against Aspergillus Fumigatus
摘要:Replacement Of One Triazole Ring Of Fluconazole With 4-Pyridinyl Leads To An Increase In Activity Against Aspergillus Fumigatus. Introduction Of An Alpha-Methyl Group Has A Marked Additional Beneficial Effect. Investigation Of Pyridinyl And Pyrimidinyl Analogues Resulted In The Identification Of 30 (Uk-109,496,Voriconazole) Which Has Excellent Potency Against A Broad Range Of Fungal Pathogens Including A. Fumigatus And Candida Krusei. Copyright (C) 1996 Elsevier Science Ltd.
Doi:10.1016/0960-894X(96)00363-0

专利信息

专利号:RU-2156760-C2
优先权日:1995-08-05
标 题 :Method of synthesis of triazoles, ultimate and intermediate compounds of method

专利号:CN-1076019-C
优先权日:1995-08-05
标 题:Synthesis of triazoles via addition of organometallic compounds to ketones and their intermediates