CAS: 1069-31-4; 2,5-Diaminopentanoic Acid Hydrochloride

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专利信息

专利号:WO-2018035410-A1
优先权日:2016-08-19
标 题:Compositions and methods of treatment using expanded-size dna analogs
发明人：POMERANTZ RICHARD T; KOOL ERIC T
权利人:UNIV TEMPLE; UNIV LELAND STANFORD JUNIOR
摘要:The present invention relates to the discovery that size-expanded DNA nucleotides and analogs thereof inhibit Ροlθ DNA synthesis activity.

专利号:US-2023089723-A1
优先权日:2020-03-06
标 题:Amino acid compositions and methods for muscle and myotube modulation
发明人：COMB WILLIAM; COKOL MURAT; KULKARNI TRIPTI
权利人:AXCELLA HEALTH INC
摘要:This disclosure provides compositions comprising amino acid entities. The disclosure also provides methods for increasing myogenesis, increasing muscle protein synthesis, increasing muscle mass, improving muscle quality or enhancing muscle function comprising administering an effective amount of the compositions to a subject in need thereof.

专利号:US-6949679-B1
优先权日:1998-04-21
标 题 :Polyamine transport inhibitors
发明人：POULIN RICHARD; AUDETTE MARIE; CHAREST-GAUDREAULT RENE
权利人:UNIV LAVAL
摘要:The present invention describes the design, synthesis and therapeutic use of a variety of novel inhibitors of polyamine transport. The main feature of this class of transport inhibitors is to incorporate a linker or side chain that prevents the uptake of polyamines and helps to conjugate polyamine analogs to form dimers with high inhibitory potency against polyamine uptake. These new compounds incorporate features that are designed to maximize their chemical and metabolic stability and their ability to bind to the polyamine transporter, and to minimize their toxicity by preventing their absorption by the cells. The purpose of such inhibitors is to prevent the uptake or salvaging of circulating polyamines by rapidly proliferating cells such as tumor cells, in order to potentiate the effect of therapeutic inhibitors of polyamine biosynthesis such as alpha-difluoromethylornithene.