CAS: 10353-53-4; 1,2-Epoxy-5-Hexene

上下游产品

Perbenzoic acid 1,5-Hexadien 1-Chloro-5-hexen-2-ol (E)-6-phenylhex-2-en-1-ol (Z)-6-phenyl-2-hexen-1-ol (E)-(5R,7S)-7-Benzenesulfonyl-deca-1,8-dien-5-ol

1,5-已二烯置于aluminum Oxide,Cesium Chloride,氧气,银体系中,化学反应 1.0H,反应生成1,2-环氧基-5-己烯
参考文献:在丁二烯存在下含烯丙基取代基的共轭烯烃的选择性环氧化和丙烯的环氧化
标题:在丁二烯存在下含烯丙基取代基的共轭烯烃的选择性环氧化和丙烯的环氧化
摘要:异戊二烯的环氧化(2-甲基-1,3-丁二烯)和戊间二烯(1,3-戊二烯),含有烯丙基甲基二者共轭烯烃,已使用常规的,氯化铯促进的,银/进行α-Al 2 ö 3种催化剂.由于存在共轭烯烃结构,对烯丙基烯烃环氧化物异构体的选择性超过20%,并且比预期的要高得多.在相同条件下,相同催化剂上丙烯的环氧化仅为2.5%.丙烯在丁二烯存在下的环氧化也可产生高得多的选择性的po.仅有1%c 4 H 6的存在在反应进料流中,以c 3 H 6转化的总活性为代价,将对po的选择性从2.5%增加到超过40%.在c 4 H 6存在下,对po的选择性上限似乎约为50%,这表明该方法的有效性上限.单独的c 4 H 6在类似的ag催化剂上的环氧化表明,进料流中过量的c 4 H 6的存在严重限制了epb与co 2 / H 2 O的连续反应.此外,对epb的选择性与c 4 H的量成正比在反应进料流中6.仅当反应进料流中有足够的c
Doi:10.1016/j.Jcat.2004.04.032

专利信息

专利号:US-9783549-B2
优先权日:2013-11-04
标题:Macrocyclization reactions and intermediates useful in the synthesis of analogs of halichondrin B
发明人：FANG FRANCIS G; KIM DAE-SHIK; CHOI HYEONG-WOOK; CHASE CHARLES E; LEE JAEMOON
权利人:EISAI R&D MAN CO LTD
摘要:The invention provides methods for the synthesis of eribulin or a pharmaceutically acceptable salt thereof (e.g., eribulin mesylate) through a macrocyclization strategy. The macrocyclization strategy of the present invention involves subjecting a non-macrocyclic intermediate to a carbon-carbon bond-forming reaction (e.g., an olefination reaction (e.g., Homer-Wadsworth-Emmons olefination), Dieckmann reaction, catalytic Ring-Closing Olefin Metathesis, or Nozaki-Hiyama-Kishi reaction) to afford a macrocyclic intermediate. The invention also provides compounds useful as intermediates in the synthesis of eribulin or a pharmaceutically acceptable salt thereof and methods for preparing the same.

专利号:US-4219489-A
优先权日:1978-09-05
标题:Synthesis of steroids
发明人：BUNES LEONARD A; JOHNSON WILLIAM S
权利人:STANFORD LELAND JUNIOR UNIV TR
摘要:Method and compounds are provided for use in the synthesis of steroids wherein a polyolefin is provided having an initiating group having a chalcogen atom in juxtaposition to a double bond, so as to be capable of bond formation to close to form a ring and having a terminating group involving pi unsaturation (a double or triple bond) conjugated to an aromatic ring. Upon acid catalysis, sigma bonds are formed through the interaction of a carbocation formed at the carbon atom bonded to the chalcogen atom and the double bond intermediate the initiating group and the terminating group, which close to form rings of a steroid nucleus, the carbocation interacting with the pi unsaturation conjugated with the aromatic group and being captured by a nucleophile present in the acidic reaction medium. The resulting steroid product may then be modified in known ways to produce known steroids.

专利号:US-2025303400-A1
优先权日:2022-05-27
标题 :Catalyst for organic synthesis use, and method for producing organic compound
发明人：KATO AYUMU; NAKAMURA SHINJI
权利人:ORGANO CORP
摘要:Provided are: a catalyst for organic synthesis use, which has a high catalytic activity, can be easily separated by solid/liquid separation from a reaction system, and enables highly efficient synthesis of an organic compound; and a method for producing an organic compound using the catalyst. This catalyst for organic synthesis use includes an anionic exchange resin that has a hydrohalic acid salt of a tertiary amino group as an ion exchange group. This method for producing an organic compound uses, as a catalyst, an anionic exchange resin that has a hydrohalic acid salt of a tertiary amino group as an ion exchange group.

专利号:US-7208532-B2
优先权日:1999-12-28
标 题:Manufacture of improved support matrices
发明人：BERGGREN EVA; LINDSTROM DAG
权利人:GE HEALTHCARE BIO SCIENCES AB
摘要:A method for the production of a cross-linked support matrix that in form of a bed will permit liquid flow velocities above 5 cm/h, preferably above 50 cm/h, to pass through the bed. The method is characterized in that it comprises the steps: (a) providing a starting support matrix that has pendent unsaturated groups, and (b) subjecting said starting support matrix to electron beam or gamma-ray irradiation. The use of a cross-linked support matrix produced by a method comprising the steps of: (a) providing a starting support matrix that has pendent unsaturated groups, and (b) subjecting said starting support matrix to electron beam or gamma-ray irradiation as a support matrix in liquid chromatography, cell culturing, step-wise solid phase synthesis of organic compounds, running catalytic reactions by the use of a solid phase bound catalyst.

专利号:US-9790398-B2
优先权日:2013-02-08
标 题 :Synthesis of polyurethane polymers via copper azide-alkyne click chemistry for coatings, adhesives, sealants and elastomer applications
发明人：CARTER NEIL; MARTIN IAN; COWARD ALEXANDER; GATRELL MARK; BYRNE MICHAEL; CULLEN JOHN E; CORMACK PETER
权利人:SIKA TECH AG
摘要:The present application is directed at the reaction product of an azide compound having two or more azide groups attached thereto and an alkyne compound having two or more alkyne groups attached thereto, wherein the azide and alkyne groups react in a 1,3-dipolar cyclo addition to form 1,4-disubstituted triazols and wherein the azide or alkyne compound or both include —O—(Câ•?O)—NR— functional groups. The reaction products can be used as coatings, such as for flat roofs, sealants, adhesives and in elastomer applications. Methods for producing the reaction products as well as substrates including a coating of the reaction product are also disclosed.

专利号:US-8921580-B2
优先权日:2012-05-09
标 题 :Methods and systems for the formation of cyclic carbonates
发明人：HATTON TREVOR ALAN; JAMISON TIMOTHY F; KOZAK JENNIFER AIDEN; SIMEON FRITZ; WU JIE
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:Described herein are inventive methods for synthesis of cyclic carbonates from CO 2 and epoxide. In some embodiments, the methods are carried out in the presence of a catalyst comprising an electrophilic halogen. In some embodiments, the methods are carried out in a flow reactor.