CAS: 101043-37-2; (5R,8S,11R,12S,15S,18S,19S,22R)-15-(3-Guanidinopropyl)-8-Isobutyl-18-((1E,3E,5S,6S)-6-Methoxy-3,5-Dimethyl-7-Phenylhepta-1,3-Dien-1-yl)-1,5,12,19-Tetramethyl-2-Methylene-3,6,9,13,16,20,25-Heptaoxo-1,4,7,10,14,17,21-Heptaazacyclopentacosane-11,22-Dicarboxylic Acid

上下游产品

1'5']undeca-8',10'-dien-6'-yl)-2-methyl-4(E)-pentenoic acid]micr°Cystin-LR[(2S,3S,1'R,3'S,4'S,5'R,6'R,7'R)-3-amino-5-(4',6'-dimethyl-3'-methoxytricyclo[5.4.0.01'5']undeca-8',10'-dien-6'-yl)-2-methyl-4(E)-pentenoic acid]micr°Cystin-LR[3H]-Dihydromicr°Cystin LR 1'5']undeca-8',10'-dien-6'-yl)-2-methyl-4(E)-pentenoic acid]micr°Cystin-LR[(2S,3S,1'R,3'S,4'S,5'R,6'R,7'R)-3-amino-5-(4',6'-dimethyl-3'-methoxytricyclo[5.4.0.01'5']undeca-8',10'-dien-6'-yl)-2-methyl-4(E)-pentenoic acid]micr°Cystin-LR 51H81N11O12SC51H81N11O12S

📜[6(Z)-Adda5]Microcystin-Lr 以 Phosphate Buffer 用作溶剂,化学反应 0.5H,反应生成微囊藻毒素(Lr亚型)
参考文献:A Photodetoxification Mechanism Of The Cyanobacterial Hepatotoxin Microcystin-Lr By Ultraviolet Irradiation
标题:A Photodetoxification Mechanism Of The Cyanobacterial Hepatotoxin Microcystin-Lr By Ultraviolet Irradiation
摘要:When Microcystin-Lr Was Exposed To Uv,Three Major Nontoxic Compounds Were Formed. These Compounds Were Identified As [4(E),6(Z)-Adda(5)] And [4(Z),6(E)-Adda(5)]Microcystin-Lr,Which Are Geometrical Isomers Of The Adda [3-Amino-9-Methoxy-2,6,8-Trimethyl-10-Phenyl-4(E),6(E)-Decadienoic Acid] Moiety Of Microcystin-Lr,And A Novel Compound,Tricyclo-Adda [(2S,3S,1'R,3'S,4'S,5'R,6'R,7'R)-3-Amino-5-(4',6'-Dimethyl-3'-Methoxytricyclo[5.4.0.0(1',5')]Undeca-8',10'-Dien-6'-yl)-2-Methyl-4(E)-Pentenoic Acid]-Containing Microcystin-Lr ([tricyclo-Adda(5)]Microcystin-Lr),Which Was Formed By [2 + 2] Addition Between The Benzene Ring And The Double Bond At Position 6-7 Of The Adda Moiety Of The Microcystin. The Geometrical Isomers Were Formed Reversibly,And Their Equilibrium Constants Were Almost The Same. [tricyclo-Adda(5)]Microcystin-Lr Was Also Formed Reversibly And Was Decomposed Under Uv Light. These Results Suggest That The Breakdown Of Microcystin-Lr By Uv Irradiation Proceeds Via [tricyclo-Adda(5)]Microcystin-Lr.
Doi:10.1021/tx970132E

专利信息

专利号:WO-2023192819-A1
优先权日:2022-03-28
标题 :Ultrafast synthesis of holey and wrinkled graphene
发明人：TOUR JAMES M; WYSS KEVIN
权利人:UNIV RICE WILLIAM M
摘要:Ultrafast synthesis of holey and wrinkled graphene and compositions thereof, and more particularly, ultrafast synthesis of holey and wrinkled graphene from carbon material, such as plastic waste via a flashing joule heating process and compositions thereof or using higher surface area materials like high surface area carbon black, activated charcoal, or biochar as starting materials with a salt additive.

专利号:US-2022133840-A1
优先权日:2020-10-30
标题:Use of microcystin in preparation of drug for preventing or treating organ and tissue fibrosis diseases
发明人：WANG YAPING; XU LIZHI; WANG JIE; Zhao qingya
权利人:NANJING UNIVERSITY OF TECHNOLOGY
摘要:Use of microcystins having a monocyclic heptapeptide structure in preparation of drugs for preventing or treating organ and tissue fibrosis diseases. Preferably, the microcystins are microcystin-LR with amino acids at positions 2 and 4 of a monocyclic heptapeptide structure thereof being leucine and arginine respectively, or are microcystin-RR with amino acids at positions 2 and 4 thereof being both arginine. Also provided is a method for inhibiting myofibroblast differentiation and collagen synthesis. The method is implemented by inhibiting a TGF-β/Smad signaling pathway by using one or more microcystins.

专利号:US-2009227575-A1
优先权日:2008-03-04
标 题 :7H-PYRROLO[2,3-H]QUINAZOLINE COMPOUNDS, THEIR USE AS mTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESIS
发明人：VENKATESAN ARANAPAKAM MUDUMBAI; CHEN ZECHENG; DOS SANTOS OSVALDO; BROOIJMANS NATASJA; GOPALSAMY ARIAMALA
权利人:WYETH CORP
摘要:A 7H-pyrrolo[2,3-h]quinazoline compound of the formula I n n n n n n n n n n wherein Ar, R 1 , R 2 , R 7 , R 8 , R 9 , R 10 , R 11 , R 12 , and n are as defined in the specification, and methods for making same.

专利号:US-2002065221-A1
优先权日:1995-12-20
标题:Control of protein synthesis, and screening method for agents
发明人：COHEN PHILIP; ALESSI DARIO; CROSS DARREN
摘要:A method for screening for agents capable of affecting the activity of kinases GSK3 and PKB is disclosed. The method involves assessing the phosphorylation of PKB on two amino acids on the PKB molecule particularly.

专利号:ES-2794012-T3
优先权日:2008-10-27
标题 :Intermediaries for the synthesis of mTOR kinase inhibitors

专利号:WO-2011053518-A1
优先权日:2009-10-26
标 题 :Methods of synthesis and purification of heteroaryl compounds