Ethyl 2-Bromo-3,3-Diethoxypropionate置于锌,苯体系中,化学反应生成3-乙氧基丙烯酸乙酯 参考文献:Oroshnik; Spoerri,Journal Of The American Chemical Society,1945,Vol. 67,P. 722 标题:Oroshnik; Spoerri,Journal Of The American Chemical Society,1945,Vol. 67,P. 722
专利信息
专利号:WO-2015198349-A1 优先权日:2014-06-25 标 题 :A one pot synthesis of 3-substituted quinoline carboxylates and its derivatives 发明人:GADAKH SUNITA KHANDERAO; SUDALAI ARUMUGAM 权利人:COUNCIL SCIENT IND RES 摘要:The present invention provides a one pot, simple, cost effective and industrially feasible catalytic synthesis of quinolines or substituted quinolines from anilines with yield >80% yield. The present invention also discloses a process for the synthesis of oxolinic acid using quinolines with yield > 45%.
专利号:US-7285686-B2 优先权日:2002-11-25 标 题:Process for the preparation of 1,3-substituted indenes 发明人:HANDFIELD JR ROBERT EUGENE; WATSON TIMOTHY J N; JOHNSON PHILLIP JAMES; ROSE PETER ROBERT 权利人:PFIZER 摘要:An improved process for the preparation of 1,3 substituted indenes which are useful intermediates in the synthesis of aryl fused azapolycyclic compounds as agents for the treatment of neurological and psychological disorders.
专利号:US-2003073834-A1 优先权日:1997-11-03 标题:Purine compounds having PDE IV inhibitory activity and methods of synthesis 发明人:CAVALLA DAVID J; CHASIN MARK; HOFER PETER 摘要:The present invention comprises compounds having the general formula I: n n n wherein: n Y 1 is N or CH n Z is selected from the group consisting of alkyl groups such as alkylene groups such as CH 2 , CH 2 CH 2 , CH(CH 3 ); alkenyl groups such as CHâ•?CH; alkynyl groups such as C≡C; and NH, N(C 1 -C 3 alkyl), O, S, C(O)CH 2 and OCH 2 ; n R 1 and R 2 are selected from the group consisting of hydrogen and a C 1 -C 8 straight or branched alkyl or a C 3 -C 8 cycloalkyl; n R 3 is a C 1 -C 12 straight or branched alkyl; n R 4 is a C 3 -C 10 cycloalkyl optionally substituted with OH or C 3 -C 10 cycloalkenyl optionally substituted with OH; and n R 8 is a C 1 -C 8 straight or branched alkyl or a C 3 -C 8 cycloalkyl, optionally substituted with OH; n and methods of synthesis.
专利号:US-5064953-A 优先权日:1983-12-29 标 题:Intermediates cephalosporin derivatives 发明人:OHNISHI HARUO; KOSUZUME HIROSHI; MIZOTA MASAHIRO; SUZUKI YASUO; MOCHIDA EI 权利人:MOCHIDA PHARM CO LTD 摘要:The present invention relates to novel cephalosporin derivatives, processes for preparing thereof, compositions for preventing and/or treating infectious diseases which comprise the novel cephalosporin derivatives as active components, and the intermediate compounds in the synthesis of cephalosporin derivatives and processes for producing thereof. The novel cephalosporin derivatives according to the present invention contain condensed heterocyclic groups, particularly a triazolopyrimidine ring or a thiadiazolopyrimidine ring as substituents at the 3-position of the cephem skeleton, and a hydroxyimino, an alkyloxyimino or an acyloxyimino moiety as substituents at the 7-position of the cephem skeleton. The compounds of the present invention containing the aforementioned substituents have a strong antibacterial activity against gram-negative bacteria and also against gram-positive bacteria including methicillin-resistant Staphylococcus aureus. These compounds are extremely useful for the treatment of infectious diseases.
专利号:US-4888332-A 优先权日:1983-12-29 标 题 :Cephalosporin derivatives 发明人:OHNISHI HARUO; KOSUZUME HIROSHI; MIZOTA MASAHIRO; SUZUKI YASUO; MOCHIDA EI 权利人:MOCHIDA PHARM CO LTD 摘要:The present invention relates to novel cephalosporin derivatives, processes for preparing thereof, compositions for preventing and/or treating infectious diseases which comprise the novel cephalosporin derivatives as active components, and the intermediate compounds in the synthesis of cephalosporin derivatives and processes for producing thereof. The novel cephalosporin derivatives according to the present invention contain condensed heterocyclic groups, particularly a triazolopyrimidine ring or a thiadiazolopyrimidine ring as substituents at the 3-position of the cephem skeleton, and a hydroxyimino, an alkyloxyimino or an acyloxyimino moiety as substituents at the 7-position of the cephem skeleton. The compounds of the present invention containing the aforementioned substituents have a strong antibacterial activity against gram-negative bacteria and also against gram-positive bacteria including methicillin-resistant Staphylococcus aureus. These compounds are extremely useful for the treatment of infectious diseases.
专利号:US-11059788-B2 优先权日:2017-06-12 标 题:Streamlined syntheses of fluoroquinolones 发明人:GUPTON FRANK B; TOSSO PERRER N 权利人:UNIV VIRGINIA COMMONWEALTH 摘要:Methods of synthesizing fluoroquinolones such as ciprofloxacin are provided. The methods utilize affordable materials, reduce the number of synthesis steps and provide high yields.
摘要:Koutentis, P. A.; Ioannidou, H. A., Science of Synthesis Knowledge Updates, (2010) 1, 287. 摘要:Sharma, U.; Kumar, R.; Gupta, S. S.; Chandra, D., Science of Synthesis Knowledge Updates, (2022) 2, 315. 摘要:Kleemann A., Kutscher B., Reichert D., Bossart M., Pharmaceutical Substances, Thieme [Online], Stuttgart, (2025).