CAS: 72432-03-2; (2R,3R,4R,5S)-1-(2-Hydroxyethyl)-2-(Hydroxymethyl)Piperidine-3,4,5-Triol

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在 Palladium On Activated Charcoal,溶剂黄146体系中,用 四氢呋喃,水 作为反应溶剂,35.0~40.0 °C,6.0 Mpa 条件下,反应 6.0H,以97.5%的收率获得产物米格列醇
参考文献:一种米格列醇的制备方法
标题:一种米格列醇的制备方法
摘要:本发明属于药物合成技术领域,具体涉及一种米格列醇的制备方法;所述方法包括步骤:(1)高压反应釜内,将pd/c,Sm‑1入反应溶剂中,加酸,搅拌,控温控压,进行氢化反应,反应结束,反应液降至室温,过滤,减压浓缩至干,得固体;(2)所得固体加入有机溶剂溶解,加入析晶溶剂进行析晶,析晶完全,过滤,真空干燥,得目标化合物米格列醇;与现有技术相比,提供了一条简便高效的制备米格列醇的方法,整个合成方法路线短,操作步骤简单,反应收率高,产品纯度高,该方法反应条件温和,可有效缩短生产周期,适合工业化放大生产.

专利信息

专利号:US-5071990-A
优先权日:1989-11-01
标题:Preparation of intermediates and the synthesis of n-(2-hydroxyethyl)-2-hydroxymethyl-3,4,5-trihydroxypiperidines
发明人：HINSKEN WERNER
权利人:BAYER AG
摘要:A process for the preparation of N-(2-hydroxyethyl)-2-hydroxymethyl-3,4,5-trihydroxypiperidines of the formula ##STR1## which comprises reacting a compound of the formula ##STR2## with glyoxal of the formula ##STR3## in a solvent to give the addition product ##STR4## and reducing such addition product (II) with a hydrogen donor reducing agent to produce the intermediates of the formula and then the end product (I).

专利号:IL-96149-A0
优先权日:1989-11-01
标 题 :Process for the preparation of intermediates and for the synthesis of n-(2-hydroxy ethyl)-2-hydroxymethyl-3,4,5-trihydroxypiperidines

专利号:ES-2082815-T3
优先权日:1989-11-01
标题:PROCEDURE FOR THE MANUFACTURE OF INTERMEDIATE PRODUCTS AND FOR THE SYNTHESIS OF N- (2-HIDROXIETIL) -2-HIDROXIMETIL-3,4,5-TRIHIDROXIPIPERIDINAS.

专利号:DK-0425929-T3
优先权日:1989-11-01
标题 :Process for the preparation of intermediates and for the synthesis of N- (2-hydroxyethyl) -2-hydroxymethyl-3,4,5-trihydroxypiperidines

专利号:CN-112592879-A
优先权日:2020-12-31
标题:A kind of recombinant Gluconobacter oxydans engineering bacteria and its application in the synthesis of miglitol intermediates

专利号:CA-2028909-C
优先权日:1989-11-01
标 题 :Preparation of intermediates and the synthesis of n-(2-hydroxy-ethyl)-2-hydroxymethyl-3,4,5-trihydroxypiperidines