CAS: 69038-81-9; 3-(2-Ethoxyphenyl)Acrylic Acid

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CAS号141-82-2 丙二酸 | CAS号613-69-4 2-乙氧基苯甲醛 | CAS号64-19-7 冰醋酸 | CAS号110-86-1 吡啶 | CAS号599151-35-6 FQI1

📜丙二酸,2-乙氧基苯甲醛置于哌啶体系中,用 吡啶 作为反应溶剂,化学反应 6.0H,反应生成 2-乙氧基肉桂酸
参考文献:通过靶向释放cgrp释放的双靶向rutaecarpine-No供体杂种作为新型抗高血压药
标题:通过靶向释放cgrp释放的双靶向rutaecarpine-No供体杂种作为新型抗高血压药
摘要:Cgrp被认为是最有效的血管扩张药,在高血压的发生和发展中起着重要的作用.trpv1和trpa1在促进cgrp的合成和释放,从而调节心血管张力方面至关重要.rutaecarpine通过刺激cgrp合成和通过激活trpv1释放而表现出有效的血管舒张和高血压作用.并且已经显示no在体内与h 2 S反应形成hno,从而激活hno-Trpa1-Cgrp途径.受联合疗法的启发,设计,合成和评估了11种芸香果树素-呋喃聚糖杂种.结果表明,大多数杂种发挥相当或改善的血管扩张活性.其中13A是离体细胞(ec)最有效的50 = 13.1 Nm)和体内.机理研究表明,杂种的血管舒张作用和抗高血压作用可能涉及通过trpv1和trpa1的双重激活促进cgrp释放.这项工作表明,双靶杂种可能是发现和开发新型抗高血压药物的有效且有前途的方法.
DOI:10.1016/j.Ejmech.2019.02.037

专利信息

专利号:US-6531470-B1
优先权日:1998-01-23
标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:US-6562844-B2
优先权日:1998-01-23
标 题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:US-7002020-B1
优先权日:1998-01-23
标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.