CAS: 66357-35-5; N-(2-(((5-((Dimethylamino)Methyl)Furan-2-yl)Methyl)Thio)Ethyl)-N'-Methyl-2-Nitroethene-1,1-Diamine

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CAS号66356-53-4 雷尼替丁杂质B | CAS号7440-44-0 活性炭 | CAS号13623-94-4 1,1-二甲硫基硝基乙烯 | CAS号66357-07-1 N-methyl-N'-(2-... | CAS号75-52-5 硝基甲烷 | CAS号66357-59-3 盐酸雷尼替丁 | CAS号15433-79-1 5-(二甲氨基)甲基-2-呋喃甲醇 | CAS号112233-24-6 (6Z)-6-[[5-[(di... | CAS号112233-23-5 5,6-二氢-3-(甲基氨基)... | CAS号112233-25-7 N,N-dimethyl-5-...

5-氯甲基呋喃-2-甲醛置于sodium Hydride,Sodium Hydroxide体系中,用 四氢呋喃,甲醇,水 作为反应溶剂,化学反应 4.08H,反应生成 雷尼替丁
参考文献:合成 雷尼替丁 (赞塔克)来自纤维素 5-(氯甲基)糠醛
标题:合成 雷尼替丁 (赞塔克)来自纤维素 5-(氯甲基)糠醛
摘要:生物质衍生的平台化学品 5-(氯甲基)糠醛 转变为重磅炸弹抗溃疡药 药品 雷尼替丁 (赞塔克)分四个步骤进行,总体孤立收率达到68%.
DOI:10.1039/c1Gc15537G

专利信息

专利号:US-9353057-B2
优先权日:2003-12-30
标 题:Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof
发明人：GALLOP MARK A; DAI XUEDONG; SCHEUERMAN RANDALL A; RAILLARD STEPHEN P; MANTHATI SURESH K; YAO FENMEI; PHAN THU; LUDWIKOW MARIA; PENG GE; BHAT SEEMA
权利人:XENOPORT INC
摘要:Methods for synthesis of 1-(acyloxy)-alkyl carbamates, particularly, the synthesis of 1-(acyloxy)-alkyl carbamate prodrugs of primary or secondary amine-containing drugs are described. Also described are methods for synthesis of 1-(acyloxy)-alkyl N-hydroxysuccinimidyl carbonates which are useful intermediates in the synthesis of 1-(acyloxy)-alkyl carbamates are also described.

专利号:WO-2004113530-A1
优先权日:2003-06-18
标题:Polynucleotide for synthesis of labeled protein
发明人：NAKA DAIJI; NAKANO HIROSHI; SHIRATORI MIWA; KOBAYASHI TERUAKI; SUZUKI KATSUHIKO; HASHIMOTO HIDEMI; SASAKI TOORU
权利人:MITSUBISHI CHEM CORP; NAKA DAIJI; NAKANO HIROSHI; SHIRATORI MIWA; KOBAYASHI TERUAKI; SUZUKI KATSUHIKO; HASHIMOTO HIDEMI; SASAKI TOORU
摘要:A process for producing a labeled protein, comprising translating a gene template in the presence of a labeled compound having a label portion consisting of a labeled substance and an acceptor portion consisting of a compound capable of binding to the C-terminus of protein synthesized by a translation system. In particular, there are provided a polynucleotide for use in synthesis of labeled protein characterized by having the capability of enhancing labeling efficiency through addition to the 3’ end of a base sequence coding for target protein within the gene template and provided a process for producing a labeled protein that is carried out with the use of the polynucleotide.

专利号:US-11136302-B2
优先权日:2017-05-26
标 题:Single step process for the synthesis of furan derivatives from carbohydrates
发明人：RODE CHANDRASHEKHAR VASANT; SHINDE SUHAS HANMANT
权利人:COUNCIL SCIENT IND RES
摘要:The present invention discloses a single step process for the synthesis of furan derivative from carbohydrate comprises stirring the reaction mixture of carbohydrate in solvent in presence of catalyst at temperature in the range of 170 to 190° C. for the period in the range of 23 to 25 hrs to afford corresponding furan derivative.

专利号:US-6852895-B2
优先权日:2000-08-15
标题:Practical, cost-effective synthesis of CoQ10
发明人：LIPSHUTZ BRUCE H; MOLLARD PAUL
权利人:ZYMES INC
摘要:The present invention provides a convergent method for the synthesis of ubiquinones and ubiquinone analogues. Also provided are precursors of ubiquinones and their analogues that are useful in the methods of the invention.

专利号:US-9546161-B2
优先权日:2001-07-16
标题:Synthesis of UDP-glucose: N-acylsphingosine glucosyl transferase inhibitors
发明人：HIRTH BRADFORD H; SIEGEL CRAIG
权利人:GENZYME CORP
摘要:Disclosed is a novel enantiomeric synthesis ceramide-like inhibitors of UDP-glucose: N-acylsphingosine glucosyltransferase. Also disclosed are novel intermediates formed during the synthesis.

专利号:US-2008287407-A1
优先权日:2003-12-10
标题 :Nitric Oxide Releasing Pyruvate Compounds, Compositions and Methods of Use
发明人：GARVEY DAVID S; FANG XINQIN; KHANAPURE SUBHASH P; RANATUNGA RAMANI R; WEY SHIOW-JYI
权利人:NITROMED INC
摘要:The invention describes novel nitrosated and/or nitrosylated pyruvate compounds and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated and/or nitrosylated pyruvate compound, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The invention also provides novel compositions comprising at least one pyruvate compound and at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one pyruvate compound, that is optionally nitrosated and/or nitrosylated, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides methods for treating diseases resulting from oxidative stress, diabetes, reperfusion injury following ischemia, preservation of tissues, organs, organ parts and/or limbs.