CAS: 615-65-6; 2-Chloro-4-Methylaniline

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CAS号38939-88-7 3-氯-4-硝基甲苯 | CAS号103-89-9 4-甲基乙酰苯胺 | CAS号99-99-0 对硝基甲苯 | CAS号18931-78-7 N-(2-氯-4-甲基苯基)乙酰胺 | CAS号623-11-0 对硝基甲苯 | CAS号623-10-9 4-(HYDROXYAMINO... | CAS号108-41-8 间氯甲苯 | CAS号34648-99-2 4-氯-5-硝基-2-甲苯胺 | CAS号112160-74-4 acetic acid-(2,... | CAS号106-49-0 对甲苯胺 | CAS号50817-80-6 2-氯-4-甲基苯甲醛 | CAS号329944-72-1 3-溴-5-氯甲苯 | CAS号38939-88-7 3-氯-4-硝基甲苯 | CAS号90631-70-2 2-氯-4-甲基苯肼 | CAS号4136-95-2 2,4,6-三氯苯酰氯 | CAS号18931-78-7 N-(2-氯-4-甲基苯基)乙酰胺 | CAS号95-75-0 3,4-二氯甲苯 | CAS号21423-84-7 2-氯-4-甲基苯腈 | CAS号7697-25-8 2-氯-4-甲基苯甲酸 | CAS号57878-93-0 2-氯-4-甲基苯基异硫氰酸酯

4-甲基乙酰苯胺置于氯,铁粉,水,Sodium Hydroxide体系中,用 1,2-二氯乙烷 作为反应溶剂,以47 %的收率获得产物2-氯-4-甲基苯胺
参考文献: A Process For The Preparation Of 2-Chloro-4-Methylaniline[fr] Procédé De Préparation De 2-Chloro-4-Méthylaniline
标题: A Process For The Preparation Of 2-Chloro-4-Methylaniline[fr] Procédé De Préparation De 2-Chloro-4-Méthylaniline
摘要:The Present Invention Discloses A Novel,Efficient And Industrially Advantageous Process For The Preparation Of 2-Chloro-4-Methylaniline Of Formula I Comprising Chlorination Of N Protected Toluidine Of Formula Iii To Obtain N Protected Ortho Chloro Toluidine Of Formula Ii Which Is Further Deprotected To Obtain 2-Chloro-4-Methylaniline Of Formula I.

专利信息

专利号:US-10005720-B2
优先权日:2013-04-05
标题:Compounds useful for the treatment of metabolic disorders and synthesis of the same
发明人：SEXTON JONATHAN Z; BRENMAN JAY E; MUSSO DAVID L
权利人:NORTH CAROLINA CENTRAL UNIV; UNIV NORTH CAROLINA CHAPEL HILL
摘要:The present invention provides compounds of Formula (I): wherein variables X, Y, Z and R1 are as described herein. Some of the compounds described herein are glutamate dehydrogenase activators. The invention is also directed to pharmaceutical compositions comprising these compounds, uses of these compounds and compositions in the treatment of metabolic disorders as well as synthesis of the compounds.

专利号:US-8653282-B2
优先权日:2007-10-18
标 题:Preparation of dihydrothieno [3,2-D] pyrimidines and intermediates used therein
发明人：FRUTOS ROGELIO; KRISHNAMURTHY DHILEEPKUMAR; MULDER JASON ALAN; RODRIGUEZ SONIA; SENANAYAKE CHRIS HUGH; TAMPONE THOMAS G
权利人:FRUTOS ROGELIO; KRISHNAMURTHY DHILEEPKUMAR; MULDER JASON ALAN; RODRIGUEZ SONIA; SENANAYAKE CHRIS HUGH; TAMPONE THOMAS G; BOEHRINGER INGELHEIM INT
摘要:The invention relates to improved methods of preparing dihydrothienopyrimidines of formula 1, and intermediates thereof, (I) wherein X is SO or SO 2 , preferably SO, and wherein R A , R 1 , R 2 , R 3 , R 4 and R 5 have the meanings given in the description. The methods according to this invention are more suitable for large-scale synthesis of said compounds than prior methods because the new synthetic process avoids distillation and chromatographic purification between steps and results in a higher overall yield of the desired product.

专利号:US-2018370905-A1
优先权日:2013-04-05
标题:Compounds Useful for the Treatment of Metabolic Disorders and Synthesis of the Same

专利号:US-5998595-A
优先权日:1996-11-05
标题:Azidohalogenobenzyl derivatives, sugar compounds and protection of hydroxy groups
发明人：KUSUMOTO SHOICHI; FUKASE KOICHI
权利人:WAKO PURE CHEM IND LTD
摘要:Azidohalogenobenzyl derivatives of the formula (I) ##STR1## wherein A is a halogen atom, B is a halogen atom or a hydrogen atom, and X is a group reactive with a hydroxy group, methods of protecting hydroxy group(s) using said derivatives, and sugar compounds wherein a hydrogen atom of at least one hydroxy group is substituted by an azidohalogenobenzyl group. According to the present invention, there are provided novel derivatives capable of introducing a group into a compound having hydroxy group(s), which group is useful as a stable hydroxy-protecting group even in solid phase synthesis for the purpose of the extension of sugar chain under continuous acidic conditions and of being removed under mild conditions; sugar compounds protected by using said derivatives; and methods of protecting hydroxy group(s) using said derivatives.

专利号:US-4136033-A
优先权日:1969-11-07
标 题:6-hydroxypyridone-2 compounds having a cationic group in the 3-position
发明人：STEINEMANN WILLY
权利人:SANDOZ LTD
摘要:Compounds of the formula ##STR1## wherein K.sup.⊕ is a cationic group, preferably heterocyclic, n R is hydrogen or an organic radical, preferably alkyl, phenyl or acyl, n R 1 is hydrogen, hydrocarbyl, substituted hydrocarbyl, heterocyclyl, substituted heterocyclyl, amino or substituted amino, and n A.sup.⊖ is an anion, n Are useful as intermediates in the synthesis of azo dyes of the formula ##STR2## wherein D is an aromatic carbocyclic or heterocyclic diazo component radical, and n K.sup.⊕, r, r 1 and A.sup.⊖ are as defined above.

专利号:US-2016046560-A1
优先权日:2013-04-05
标题 :Compounds useful for the treatment of metabolic disorders and synthesis of the same