CAS: 47375-34-8; Boc-Tyr(Tbu)-Oh

相似化合物

507276-74-6 118488-18-9 133373-24-7

上下游产品

CAS号24424-95-1 bis[(2-methylpr... | CAS号58822-25-6 [Leu5]-脑啡肽

Di-Tert-Butyl Tricarbonate,O-叔丁基-L-酪氨酸置于sodium Hydroxide体系中,用 1,4-二氧六环,水 作为反应溶剂,以76%的收率获得产物boc-O-叔丁基-L-酪氨酸
参考文献:Atherton,Eric; Caviezel,Mario; Fox,Hazel,Journal Of The Chemical Society. Perkin Transactions I,1983,# 1,P. 65-73
标题:Atherton,Eric; Caviezel,Mario; Fox,Hazel,Journal Of The Chemical Society. Perkin Transactions I,1983,# 1,P. 65-73

专利信息

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-6989401-B2
优先权日:2000-07-19
标题:Sulfonic acid derivatives of hydroxamic acids and their use as medicinal products
发明人：MAEDA KAZUHIRO; SONDA SHUJI; TAKEMOTO TADAHIRO; GOTO TOMOKAZU; KOBAYASHI FUJIO; KAJII MASAHIKO; KOMORITA NARUYASU; HIRAYAMA FUMIHIRO
权利人:MITSUBISHI PHARMA CORP
摘要:The present invention relates to a novel sulfonic acid derivative of hydroxamic acid or a pharmacologically acceptable salt thereof. More particularly, the present invention relates to a sulfonic acid derivative of hydroxamic acid or a pharmacologically acceptable salt thereof, which is useful as an inhibitor of lipopolysaccharides (LPS). In addition, the present invention relates to a novel intermediate compound useful for the synthesis of this sulfonic acid derivative of hydroxamic acid.

专利号:US-7759514-B2
优先权日:2002-10-11
标题:Mu opioid receptor ligands: methods of use and synthesis
发明人：HARRISON BRYCE A; GIERASCH TIFFANY MALINKY; VERDINE GREGORY L; SHI ZHANGJIE
权利人:HARRISON BRYCE A; GIERASCH TIFFANY MALINKY; VERDINE GREGORY L; SHI ZHANGJIE
摘要:Novel compounds and compositions including those compounds, as well as methods of using and making the compounds are herein described. The compounds are useful in therapeutic applications, including modulation of disease or disease symptoms in a subject (e.g., mammal, human, dog, cat, horse). The compounds are useful as modulators of the mu opioid receptor (MOR) through their binding affinity with that receptor.

专利号:WO-8203077-A1
优先权日:1981-03-10
标题:High performance peptide synthesis
发明人：VERLANDER MICHAEL S; FULLER WILLIAM DEAN; GOODMAN MURRAY
权利人:BIORESEARCH INC
摘要:Method for synthesizing a polypeptide chain on an insoluble solid support, in which an amino acid is introduced into a reactor filled with an insoluble solid support containing substituent groups reacting with this amino acid, the method consisting in coupling this amino acid to the support by a condensation reaction with the reactive substituent groups, to introduce a second analogous or different amino acid into the reactor and to couple the second amino acid to the first amino acid and to repeat the process until the desired polypeptide is obtained, the improvement being constituted by the use of a pressurized flow system making it possible to obtain rapid reactions and high production yields of the desired products.

专利号:US-2004254225-A1
优先权日:2002-10-11
标题 :Mu opioid receptor ligands: methods of use and synthesis

专利号:US-7223888-B2
优先权日:2002-10-11
标 题 :Mu opioid receptor ligands: methods of use and synthesis