CAS: 4696-76-8; (2R,3S,4R,5R,6R)-5-Amino-2-(Aminomethyl)-6-(((1R,2S,3S,4R,6S)-4,6-Diamino-3-(((2S,3R,4S,5S,6R)-4-Amino-3,5-Dihydroxy-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-2-yl)Oxy)-2-Hydroxycyclohexyl)Oxy)Tetrahydro-2H-Pyran-3,4-Diol

上下游产品

CAS号2037-48-1 2-脱氧链胺,二氢溴化物 | CAS号60183-25-7 3-Amino-3-deoxy... | CAS号59433-00-0 2,6-Diamino-2,6... | CAS号3847-27-6 kanamycin A sulphate

专利信息

专利号:US-RE28647-E
优先权日:1971-06-02
标 题:Preparation of 3-4 dideoxykanamycin B active against resistant bacteria
摘要:Synthesis of 3''-4''-dideoxykanamycin B which comprises protecting the amino and all or a part of the hydroxyl groups other than 3'' and 4''-hydroxyl groups of kanamycin B, sulfonylating 3''- and 4''hydroxyl groups to give a derivative having disulfonic ester groups, removing said ester groups to give 3''-4''-unsaturated compound, reducing said compound and finally removing the residual protecting groups.

专利号:US-4337336-A
优先权日:1980-02-25
标 题:Derivative of kanamycin A and a process for the preparation thereof
发明人：UMEZAWA HAMAO; UMEZAWA SUMIO; FUKATSU SHUNZO; YONETA TOSHIO; WAKAZAWA TADASHI
权利人:MICROBIAL CHEM RES FOUND
摘要:There are provided new compounds, 3',4'-anhydro-4'-epi derivatives of kanamycin A of the formula: ##STR1## wherein R represents an alkyl, aralkyl or aryl group and Y represents an alkylidene, aralkylidene, cycloalkylidene or tetrahydropyranylidene group which are useful as an intermediate for the synthesis of 3',4'-dideoxykanamycin A and 4'-deoxykanamycin A from kanamycin A. The compounds of formula (I) can be prepared by treating the corresponding 4'-O-sulfonyl derivative with an alkali metal alcoholate in a lower alkanol under an alkaline condition.

专利号:US-4156078-A
优先权日:1975-12-11
标 题:Process for the synthesis of 3',4'-dideoxykanamycin B and products
发明人：TSUCHIYA TSUTOMU; UMEZAWA HAMAO; UMEZAWA SUMIO
权利人:MICROBIAL CHEM RES FOUND
摘要:A useful antibiotic, 3',4'-dideoxykanamycin B can be prepared in shortened steps and in an improved overall yield by a new process starting from kanamycin B via new intermediate derivatives of kanamycin B in which all the amino groups and possibly the 2'-hydroxyl group are protected with sulfonyl-type protecting groups selected from lower alkyl-, aryl- and aralkyl-sulfonyl groups.

专利号:US-6833445-B2
优先权日:2000-01-21
标题:Guanidinylation, guanidinoglycosides, uses, and methods of assaying their activity
发明人：GOODMAN MURRAY; TOR YITZHAK; BAKER TRACY; LUEDTKE NATHAN
权利人:UNIV CALIFORNIA
摘要:Provided are reagents and methods useful for the synthesis of guanidinylated compounds. Also provided are methods for assaying molecules, including guanidinylated molecules that modulate viral infection and replication.

专利号:US-10472663-B2
优先权日:2015-01-21
标 题:Procedure for the rapid determination of bacterial susceptibility to antibiotics that inhibit protein synthesis
发明人：FERNÃ?NDEZ GARCÃ?A JOSÉ LUIS; GOSÃ?LVEZ BERENGUER JAIME; BOU ARÉVALO GERMÃ?N; TAMAYO NOVAS MARIA; SANTISO BRANDARIZ REBECA; OTERO FARIÑA FÃ?TIMA MARÃ?A
权利人:ABM TECH LLC
摘要:The present invention relates to a method for the rapid evaluation of bacterial susceptibility or non-susceptibility of bacteria to antibiotics that inhibit protein synthesis. The rationale is to identify bacterial responses that depend or are influenced by protein synthesis. If this response is prevented or reduced by the antibiotic that inhibits the protein synthesis, the bacteria are susceptible to this antibiotic. Otherwise, if the response keeps similar despite the incubation with the antibiotic, the bacteria are not susceptible or resistant to this antibiotic. These responses could be determined at the DNA lev-el, cell wall level, morphological level or any other experimental approach, including metabolic, bio-chemical, physiological or genetic processes.

专利号:US-2008206803-A1
优先权日:2001-09-28
标题:Metabolic genes and related methods and compositions
发明人：GALLIVAN JUSTIN
权利人:CALIFORNIA INST OF TECHN
摘要:Certain aspects of the invention provide nucleic acid constructs that can be used to cause a cell to be dependent on a particular enzymatic activity or on the presence of a particular small molecule. Certain aspects of the invention also provide methods for cloning genes involved in the synthesis, modification or degradation of a given molecule and for the directed evolution of proteins that perform a specified enzymatic function. Certain methods of the invention can be used to isolate the genes responsible for directing the biosynthesis, modification or degradation of a particular target molecule and to isolate polypeptide variants having new or improved enzymatic activity.