CAS: 30672-46-9; N-(2-Hydroxyethyl)Piperidine-4-Carboxamide

该化合物是一个化学化合物,其特点是管状环结构,有六人组成,含氮的乙型循环循环.该化合物的特点是一个箱式聚氨酯功能组和一个氢氧乙基替代体,有助于极地溶剂溶解性.它通常是白色到白色的,在室温下是非白色的固体,在标准条件下具有中等稳定性.该氢氧基组的存在增加了其氢联结潜力,这可能影响其再活动以及与生物系统的互动.该化合物可能因其结构特征而对制药研究感兴趣,这可能会带来具体的生物活动.此外,在药物设计方面,特别是在开发针对各种生物途径的化合物方面,可以进一步探讨其特性.与许多化学物质一样,应参考安全数据,以了解其在实验室环境中的处理和潜在危害.

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73415-61-9 1423023-98-6 1084331-38-3

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4-(2-Hydroxy-ethylcarbamoyl)-piperidine-1-carboxylic acid benzyl ester 16H22N2O5C16H22N2O5

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    专利信息


    专利号:US-4721788-A
    优先权日:1985-07-12
    标题:4-cyanopiperidine derivatives
    发明人：YAMAUCHI HIROSHI; NOMOTO SEIICHIRO; SUGIYAMA ISAO; KOMATU YUUKI; KANAI TAKEO; TAKAYANAGI KEIZO; TANAKA YASUHIDE; KOIWA ATSUSHI; ENDOH SHINICHI
    权利人:EISAI CO LTD
    摘要:A novel 4-cyanopiperidine derivative, which is represented by the following general formula (I): ##STR1## wherein X means a halogen atom, or an acid addition salt thereof, is prepared by reacting N-(2-hydroxyethyl)-4-carbamoylpiperidine or an acid addition salt thereof with a dehydrating and halogenating agent; or by reacting 4-cyanopiperidine or a salt thereof with a compound represented by the following general formula (IV): n n X--CH.sub.2 CH.sub.2 --Y (IV) n n wherein X has the same meaning as defined above and Y denotes the same halogen atom as X or another halogen atom. The derivative is useful as intermediate for synthesis of quinuclidine derivative which is in turn useful as intermediate for the production of medicines, chemicals, etc.

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    摘要:Chen, Z.-P.; Zhou, Y.-G., Science of Synthesis: Catalytic Reduction in Organic Synthesis, (2017) 1, 157.
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