CAS: 304445-49-6; 4'-Bromo-3'-Fluoroacetophenone

上下游产品

CAS号676-58-4 甲基氯化镁 | CAS号343564-56-7 4-溴-3-氟-N-甲氧基-N-甲基苯胺 | CAS号153556-42-4 4-溴-3-氟苯甲酸 | CAS号897016-95-4 (4-溴-3-氟-苯基)-吗啉... | CAS号695188-21-7 4-溴-3-氟苯甲酰氯 | CAS号214760-18-6 4-乙酰基-2-氟苯甲腈

1-(4-Bromo-3-Fluorophenyl)Ethanol置于重铬酸吡啶体系中,用 二氯甲烷 作为反应溶剂,以3.08 G的收率获得产物4-溴-3-氟苯乙酮
参考文献: 3-Pyrimidin-4-Yl-Oxazolidin-2-Ones As Inhibitors Of Mutant Idh[fr] 3-Pyrimidin-4-Yl-Oxazolidin-2-Ones Comme Inhibiteurs D'Idh Mutante
标题: 3-Pyrimidin-4-Yl-Oxazolidin-2-Ones As Inhibitors Of Mutant Idh[fr] 3-Pyrimidin-4-Yl-Oxazolidin-2-Ones Comme Inhibiteurs D'Idh Mutante
摘要:这项发明涉及一种式(I)的配方,或其药用可接受的盐,其中r1,R2A,R2B和r3-R7在此处.该发明还涉及含有式(I)化合物的组合物,以及在抑制具有新型活性的突变idh蛋白中使用这种化合物的用途.该发明还涉及在治疗与这种突变idh蛋白相关的疾病或紊乱中使用式(I)化合物,包括但不限于细胞增殖紊乱,如癌症.

专利信息

专利号:WO-2020248278-A1
优先权日:2019-06-14
标题:Method for continuous synthesis of substituted benzoic-acid organic substance
发明人：HONG HAO; ZHANG ENXUAN; LU JIANGPING; LIU ZHIQING; LI CHAO; TANG YANG
权利人:JINLIN ASYMCHEM LABORATORIES CO LTD
摘要:The present invention provides a method for the continuous synthesis of a substituted benzoic-acid organic substance. The continuous synthesis method comprises: in the presence of catalyst and organic solvent, the organic matter represented by formula (I) and oxygen are continuously inputted to a continuous reaction apparatus for continuous oxidation reaction to obtain a substituted benzoic-acid organic substance, which is discharged continuously, the substituted benzoic-acid organic substance having the structure represented by formula (II). Oxygen is a green reagent and is inexpensive and readily available; a large amount of wastewater, waste gas, and solid waste is not generated after the reaction, and the system is easy to handle. The use of a continuous reaction operation can reduce the risk of flash distillation and explosion of solvent due to a high concentration of oxygen in a batch reaction. Under the same oxidation conditions, the continuous preparation process can reduce the escape of oxygen, greatly increasing the oxygen utilization rate and also simplifying the operation, improving the safety of the reaction and the yield of the substituted benzoic-acid organic substance.

专利号:CN-102372618-B
优先权日:2011-10-20
标题 :Practical Synthesis of 2-Halo-1-(4-Bromo-3-fluorophenyl)ethanone

专利号:CN-102372618-A
优先权日:2011-10-20
标题:Practical Synthesis of 2-Halo-1-(4-Bromo-3-fluorophenyl)ethanone