CAS: 27493-61-4; (S)-2-((S)-2-Amino-3-Methylbutanamido)Propanoic Acid

相似化合物

24787-89-1 70396-18-8 150114-97-9

上下游产品

N-(N-trifluoroacetyl-L-valyl)-L-alanine methyl esterN-(N-trifluoroacetyl-L-valyl)-L-alanine methyl ester N-(D-α-bromo-isovaleryl)-L-alanineN-(D-α-bromo-isovaleryl)-L-alanine (S)-2-((S)-2-(((benzyloxy)carbonyl)amino)-3-methylbutanamido)propanoic acid (S)-2-((S)-2-Amino-3-methyl-butyrylamino)-propionic acid benzyl ester(9H-fluoren-9-yl)methyl ((S)-1-(((S)-1-((4-((S)-1-(2-((tert-butoxycarbonyl)amino)-5-methoxy-4-((triisopropylsilyl)oxy)benzoyl)-5-(hydroxymethyl)-4, 5-dihydro-1H-pyrrol-3-yl)phenyl)amino)-1-oxopropan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)carbamate (9H-fluoren-9-yl) methyl ((S)-3-methyl-1-oxo-1-(((S)-1-oxo-1-((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)amino)propan-2-yl)amino)butan-2-yl)carbamate D-Alanine L-valine

苄氧羰基-L-缬氨酰-L-丙氨酸置于palladium On Activated Charcoal,氢气体系中,用 甲醇 用作溶剂,化学反应 16.0H,以1.2%的收率获得(S)-2-((S)-2-氨基-3-甲基丁酰胺)丙酸
参考文献:Wo2020006018A5
标题:Wo2020006018A5

专利信息

专利号:WO-2024186075-A1
优先权日:2023-03-03
标题 :Synthesis method of antibody-drug conjugates using proximity effect-based site-selective antibody labeling
发明人：LEE HYUN SOO; KIM SOOIN; KWEON YONGSEOK
权利人:UNIV SOGANG RES & BUSINESS DEVELOPMENT FOUND; RESEARCH & BUSINESS FOUNDATION SUNGKYUNKWAN UNIV
摘要:The present invention relates to a method for the synthesis of an antibody-drug conjugate using proximity effect-based site-selective antibody labeling. Provided according to the present invention may be a method for the synthesis of an antibody-drug conjugate by site-selectively introducing a drug into an antibody using a pyridinium oxime derivative (labeling mediator protein) introduced into a binding protein containing a non-standard amino acid.

专利号:US-2023220001-A1
优先权日:2020-06-09
标 题:Method for synthesis of thioether-containing peptides
发明人：GRUSS HENDRIK; LUTZ CHRISTIAN; SÃœSSMUTH RODERICH; Yao guiyang; KNITTEL CAROLINE; KOSOL SIMONE; MAINZ ANDI
权利人:HEIDELBERG PHARMA RES GMBH
摘要:The present invention relates to a method of formation of a sulphur bridge between tryptophan and cysteine in solid phase peptide synthesis under iodine treatment. The invention also relates to the resulting compounds of the method and their respective use.

专利号:US-2007166281-A1
优先权日:2004-08-21
标题 :Chloroquine coupled antibodies and other proteins with methods for their synthesis
发明人：KOSAK KENNETH M
权利人:KOSAK KENNETH M
摘要:This invention discloses compositions of chloroquine-coupled active agents such as therapeutic antibodies or insulin, including methods for their preparation. The prior art has shown that chloroquines given as free drug in high enough concentration, enhances the release of various agents from cellular endosomes into the cytoplasm. The purpose of these compositions is to provide a controlled amount of chloroquine at the same site where the drug is delivered, thereby reducing the overall dosage needed. The compositions comprise a chloroquine substance coupled to a drug directly or through a variety of pharmaceutical carrier substances. The carrier substances include polysaccharides, synthetic polymers, proteins, micelles and other substances for carrying and releasing the chloroquine compositions in the body for therapeutic effect. The compositions can also include a biocleavable linkage for carrying and releasing the drug for therapeutic or other medical uses. The invention also discloses carrier compositions that are coupled to targeting molecules for targeting the delivery of chloroquine substances and antibody or insulin to their site of action.

专利号:US-2018147294-A1
优先权日:2013-06-06
标 题:Antibody-drug conjugates, compositions and methods of use
发明人：JACKSON DAVID Y; HA EDWARD; PROBST GARY D
权利人:JACKSON DAVID Y; HA EDWARD; PROBST GARY D
摘要:Antibody-cytotoxin antibody-drug conjugates and related compounds, such as linker-cytotoxin conjugates and the linkers used to make them, tubulysin analogs, and intermediates in their synthesis; compositions; and methods, including methods of treating cancers.

专利号:US-9745303-B2
优先权日:2012-10-12
标题:Synthesis and intermediates of pyrrolobenzodiazepine derivatives for conjugation
发明人：HOWARD PHILIP WILSON
权利人:SPIROGEN SÀRL; MEDIMMUNE LTD
摘要:A method of synthesing a compound of formula (I) from a compound of formula (III).

专利号:US-2022135594-A1
优先权日:2019-02-25
标题:Methods of synthesis and intermediates
发明人：HOWARD PHILIP WILSON; CAILLEAU THAIS
权利人:MEDIMMUNE LTD
摘要:A method of synthesising a compound of formula (I) from a compound of formula (II) wherein R2 is phenyl, substituted at either the meta- or para-position by the group (III) where Q is an amino acid residue (—C(â•?O)—X1—NH—), a di-amino acid residue (—C(â•?O)—X1—X2—NH—) or a tri-amino acid residue (—C(â•?O)—X1—X2—X3—NH—); ProtN3 is an amino protecting group; R2pre is phenyl, substituted at the same position as R2 by —NH2; comprising reacting a compound of formula (II) with a compound of formula (IV) in the presence of HATU in dichloromethane or chloroform or a mixture thereof.