(5-羧基戊基)三苯基溴化磷置于氯化亚砜,Potassium Tert-Butylate体系中,用 乙醚,N,N-二甲基甲酰胺 用作溶剂,化学反应 27.5H,反应生成(Z)-辣椒素 参考文献:A Facile Procedure For Synthesis Of Capsaicin 标题:A Facile Procedure For Synthesis Of Capsaicin 摘要: Doi:10.1021/jo00275A040
专利号:EP-4630405-A1 优先权日:2022-12-06 标题 :Process for the synthesis of substituted tetrahydrofuran modulators of sodium channels
专利号:WO-2024123815-A1 优先权日:2022-12-06 标 题:Process for the synthesis of substituted tetrahydrofuran modulators of sodium channels
专利号:US-7632519-B2 优先权日:2005-04-25 标 题:TRPV1 agonist compounds, formulations, prodrugs, methods for using the same 发明人:JAMIESON GENE CURTIS; MUHAMMAD NAWEED; BLEY KEITH R 权利人:NEUROGESX INC 摘要:Described here are TRPV1 agonist compounds and their methods of synthesis and use. In addition to specifically identified compounds, capsaicin prodrugs, gemini dimers, and mutual prodrugs are also described. Formulations of the TRPV1 agonist compounds may be in the form of a liquid, tablets, capsules, gel, cream, emulsion, a patch, or the like. Methods for treating medical conditions using the compounds, compositions, or prodrugs described, are also provided.
专利号:US-2014315720-A1 优先权日:2012-10-24 标 题 :Polysaccharide ester microspheres and methods and articles relating thereto 发明人:FALLON DENIS G; GARRETT THOMAS S; KIZER LAWTON E; ZAZZARA KAREN L; COMBS MICHAEL T; JOHNSON RICHARD K; DEHART GARY 权利人:CELANESE ACETATE LLC 摘要:A method for producing a polysaccharide ester microsphere may include forming a polysaccharide ester product from a polysaccharide synthesis, wherein the polysaccharide ester product comprises a polysaccharide ester and a solvent; diluting the polysaccharide ester product, thereby yielding a polysaccharide ester dope; and forming a plurality of polysaccharide ester microspheres from the polysaccharide ester dope. Suitable polysaccharides may include, but are not limited to, starch, cellulose, hemicellulose, algenates, chitosan, and any combination thereof. Esters thereof may be organic esters (e.g., acetate and the like), inorganic esters (e.g., sulfonates and the like), or combinations thereof. Further, the solids conent of the polysaccharide ester dope, in some instances, may be greater than about 16 wt %.
专利号:CN-1865234-A 优先权日:2006-06-15 标 题:Chemical synthesis and purification method of capsaicin
专利号:CN-101208345-B 优先权日:2005-05-25 标 题 :(S) -N-methylnaltrexone, method of synthesis and pharmaceutical use thereof