CAS: 25775-90-0; (Z)-N-(4-Hydroxy-3-Methoxybenzyl)-8-Methylnon-6-Enamide

该化合物是加拿大2010年7月批准的一种热门止痛剂,可与口服COX-2抑制剂或非物质刺激剂一起使用,以缓解膝盖骨髓炎的成年人的严重疼痛.Zucapsaisin是天然产物骨髓炎的精密异构体.Capsaisin没有奶油,润滑剂和治疗...

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CAS号1196-92-5 4-(氨基甲基)-2-甲氧基苯酚 | CAS号31467-60-4 (6Z)-8-甲基-6-壬烯酸 | CAS号50889-29-7 5-羧基戊基-三苯基溴化磷 | CAS号121-33-5 香草醛 | CAS号502-44-3 ε-己内酯 | CAS号6654-36-0 6-氧代己酸甲酯 | CAS号4547-43-7 6-羟基己酸甲酯 | CAS号112375-42-5 methyl 8-methyl... | CAS号19408-84-5 二氢辣椒素

合成工艺路线路线简述

    (5-羧基戊基)三苯基溴化磷置于氯化亚砜,Potassium Tert-Butylate体系中,用 乙醚,N,N-二甲基甲酰胺 用作溶剂,化学反应 27.5H,反应生成(Z)-辣椒素
    参考文献:A Facile Procedure For Synthesis Of Capsaicin
    标题:A Facile Procedure For Synthesis Of Capsaicin
    摘要:
    Doi:10.1021/jo00275A040

    海关参考信息

    专利信息


    专利号:EP-4630405-A1
    优先权日:2022-12-06
    标题 :Process for the synthesis of substituted tetrahydrofuran modulators of sodium channels

    专利号:WO-2024123815-A1
    优先权日:2022-12-06
    标 题:Process for the synthesis of substituted tetrahydrofuran modulators of sodium channels

    专利号:US-7632519-B2
    优先权日:2005-04-25
    标 题:TRPV1 agonist compounds, formulations, prodrugs, methods for using the same
    发明人:JAMIESON GENE CURTIS; MUHAMMAD NAWEED; BLEY KEITH R
    权利人:NEUROGESX INC
    摘要:Described here are TRPV1 agonist compounds and their methods of synthesis and use. In addition to specifically identified compounds, capsaicin prodrugs, gemini dimers, and mutual prodrugs are also described. Formulations of the TRPV1 agonist compounds may be in the form of a liquid, tablets, capsules, gel, cream, emulsion, a patch, or the like. Methods for treating medical conditions using the compounds, compositions, or prodrugs described, are also provided.

    专利号:US-2014315720-A1
    优先权日:2012-10-24
    标 题 :Polysaccharide ester microspheres and methods and articles relating thereto
    发明人:FALLON DENIS G; GARRETT THOMAS S; KIZER LAWTON E; ZAZZARA KAREN L; COMBS MICHAEL T; JOHNSON RICHARD K; DEHART GARY
    权利人:CELANESE ACETATE LLC
    摘要:A method for producing a polysaccharide ester microsphere may include forming a polysaccharide ester product from a polysaccharide synthesis, wherein the polysaccharide ester product comprises a polysaccharide ester and a solvent; diluting the polysaccharide ester product, thereby yielding a polysaccharide ester dope; and forming a plurality of polysaccharide ester microspheres from the polysaccharide ester dope. Suitable polysaccharides may include, but are not limited to, starch, cellulose, hemicellulose, algenates, chitosan, and any combination thereof. Esters thereof may be organic esters (e.g., acetate and the like), inorganic esters (e.g., sulfonates and the like), or combinations thereof. Further, the solids conent of the polysaccharide ester dope, in some instances, may be greater than about 16 wt %.

    专利号:CN-1865234-A
    优先权日:2006-06-15
    标 题:Chemical synthesis and purification method of capsaicin

    专利号:CN-101208345-B
    优先权日:2005-05-25
    标 题 :(S) -N-methylnaltrexone, method of synthesis and pharmaceutical use thereof
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    主要参考文献


    1: Mosa FES, Alqahtani MA, El-Ghiaty MA, Barakat K, El-Kadi AOS. Identifying novel aryl hydrocarbon receptor (AhR) modulators from clinically approved drugs: In silico screening and In vitro validation. Arch Biochem Biophys. 2024 Apr;754:109958. doi: 10.1016/j.abb.2024.109958. Epub 2024 Mar 16. 24(2):1413. doi: 10.3390/ijms24021413.
    3: Courault P, Demarquay G, Zimmer L, Lancelot S. Cluster headache: state of the art of pharmacological treatments and therapeutic perspectives. Fundam Clin Pharmacol. 2021 Jun;35(3):595-619. doi: 10.1111/fcp.12636. Epub 2020 Dec 24. 141(43):17086-17091. doi: 10.1021/jacs.9b09336. Epub 2019 Oct 21.
    5: Rodriguez-Merchan EC. Topical therapies for knee osteoarthritis. Postgrad Med. 2018 Sep;130(7):607-612. doi: 10.1080/00325481.2018.1505182. Epub 2018 Aug 29. 23(10):1433-40. doi: 10.1517/13543784.2014.956079. Epub 2014 Aug 29. 39(3):610-20. doi: 10.3899/jrheum.110192. Epub 2011 Nov 15. 28(6):379-412. 18(10):671-85. doi: 10.2165/00023210-200418100-00004. 7(2):139-43. doi: 10.1007/s11916-003-0024-2. 59(6):990-4. doi: 10.1001/archneur.59.6.990. 20(6):597-602. doi: 10.1046/j.1468-2982.2000.00088.x. 43(11):2685-8. doi: 10.1128/AAC.43.11.2685.

    合成参考文献


    摘要:Product monograph
    参考文献:10.1128/aac.43.11.2685
    摘要:Bourne N, Bernstein DI, Stanberry LR. Civamide ( cis -Capsaicin) for Treatment of Primary or Recurrent Experimental Genital Herpes. Antimicrob Agents Chemother. 1999 Nov;43(11):2685–8. doi: 10.1128/aac.43.11.2685.
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