CAS: 173089-80-0; Quinolin-6-Yl Trifluoromethanesulfonate

相似化合物

108530-08-1 163485-84-5 177734-78-0

上下游产品

CAS号580-16-5 6-羟基喹啉 | CAS号358-23-6 三氟甲磺酸酐 | CAS号612-57-7 6-氯喹啉 | CAS号396-30-5 6-氟喹啉 | CAS号38896-30-9 6-喹啉羧酸甲酯 | CAS号99071-54-2 6-氨基甲基喹啉 | CAS号612-95-3 6-苯基喹啉 | CAS号613-50-3 6-硝基喹啉 | CAS号1020172-07-9 N-[3-叔丁基-1-(喹啉-...

📜6-羟基喹啉 以100的收率获得6-喹啉基三氟甲烷磺酸酯
参考文献: Methods And Compositions For The Treatment Of Myeloproliferative Diseases And Other Proliferative Diseases[fr] Méthodes Et Compositions Pouvant être Utilisées En Vue Du Traitement De Maladies Myéloprolifératives Et D'Autres Maladies Prolifératives
标题: Methods And Compositions For The Treatment Of Myeloproliferative Diseases And Other Proliferative Diseases[fr] Méthodes Et Compositions Pouvant être Utilisées En Vue Du Traitement De Maladies Myéloprolifératives Et D'Autres Maladies Prolifératives
摘要:本发明的化合物在治疗增生性疾病,哺乳动物癌症,特别是人类癌症方面具有实用性,包括但不限于恶性黑色素瘤,胶质母细胞瘤,卵巢癌,胰腺癌,前列腺癌,肺癌,乳腺癌,肾癌,宫颈癌,原发肿瘤部位和转移部位的转移,骨髓增生性疾病,慢性髓性白血病,急性淋巴细胞白血病,乳头状甲状腺癌,非小细胞肺癌,间皮瘤,高嗜酸性综合症,胃肠道间质瘤,结肠癌,甲状腺癌,眼部疾病,包括各种视网膜病变,如糖尿病性视网膜病变和老年性黄斑变性,类风湿性关节炎,哮喘,慢性阻塞性肺疾病,人类炎症,类风湿脊柱炎,骨关节炎,痛风性关节炎,败血症,脓毒症,内毒素性休克,革兰氏阴性菌感染,毒性休克综合症,成人呼吸窘迫综合症,中风,再灌注损伤,神经创伤,神经缺血,银屑病,再狭窄,慢性阻塞性肺疾病,骨吸收性疾病,移植物抗宿主反应,克罗恩病,溃疡性结肠炎,炎症性肠病,发热和以上疾病的组合,由c-Abl激酶,其致癌形式,异常融合蛋白和多态形式引起的疾病,C-Kit激酶,其致癌形式,异常融合蛋白和多态形式引起的疾病,Vegfr激酶,其致癌形式,异常融合蛋白和多态形式引起的疾病,Pdgfr激酶,其致癌形式,异常融合蛋白和多态形式引起的疾病,Flt-3激酶,其致癌形式,异常融合蛋白和多态形式引起的疾病,Tie-2激酶,其致癌形式,异常融合蛋白和多态形式引起的疾病,Trk激酶,其致癌形式,异常融合蛋白和多态形式引起的疾病,C-Met激酶,其致癌形式,异常融合蛋白和多态形式引起的疾病,或由her激酶,其致癌形式,异常融合蛋白和多态形式引起的疾病.

专利信息

专利号:US-8188113-B2
优先权日:2006-09-14
标 题 :Dihydropyridopyrimidinyl, dihydronaphthyidinyl and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
发明人：FLYNN DANIEL L; PETILLO PETER A; KAUFMAN MICHAEL D; PATT WILLIAM C
权利人:FLYNN DANIEL L; PETILLO PETER A; KAUFMAN MICHAEL D; PATT WILLIAM C; DECIPHERA PHARMACEUTICALS INC
摘要:The present invention relates to novel dihydropyridopyrimidinyl, dihydronaphthyridinyl, and related compounds which are kinase inhibitors and modulator useful for the treatment of various diseases. More particularly, the invention is concerned with such compounds, kinase/compound adducts, methods of treating diseases, and methods of synthesis of the compounds. Preferably, the compounds are useful for the modulation of kinase activity of Raf kinases and disease polymorphs thereof. Compounds of the present invention find utility in the treatment of mammalian cancers and especially human cancers including but not limited to malignant melanoma, colorectal cancer, ovarian cancer, papillary thyroid carcinoma, non small cell lung cancer, and mesothelioma. Compounds of the present invention also find utility in the treatment of rheumatoid arthritis and retinopathies including diabetic retinal neuropathy and macular degeneration.

专利号:WO-9531458-A1
优先权日:1992-10-13
标 题:3-hydroxyquinuclidin-3-ylphenylquinolines as squalene synthase inhibitors
发明人：NEUENSCHWANDER KENT W; GRONEBERG ROBERT D; MORRIS ROBERT L; SCOTESE ANTHONY C; MAGUIRE MARTIN P
权利人:RHONE POULENC RORER PHARMA; NEUENSCHWANDER KENT W; GRONEBERG ROBERT D; MORRIS ROBERT L; SCOTESE ANTHONY C; MAGUIRE MARTIN P
摘要:This invention relates to a class of novel compounds useful in the treatment of diseases associated with undesirable cholesterol levels in the body, and particularly diseases of the cardiovascular system, such as atherosclerosis. The compounds of this invention are novel quinolinyl phenyl 3-hydroxyquinuclidines which may be linked directly or through a chain linking the quinolinyl to the phenyl and/or the phenyl to the quinuclidine. Compounds of this invention exhibit squalene synthase inhibition properties and reduce levels of serum cholesterol without significantly reducing mevalonic metabolite synthesis and thus provide a therapeutic agent having fewer side effects than agents which act by inhibiting the HMG-CoA reductase enzyme. Compounds of the present invention may also be useful in treating fungal infections. This invention further relates to pharmacological compositions and method of treatment for lowering serum cholesterol levels using the compounds of this invention.