CAS: 169685-29-4; 4-(Trifluoromethoxy)Thiophenol
该化合物是一种有机硫化合物,其特点是存在三氟甲基苯氧基组,以三氟甲基苯氧基组替代硫酚,该化合物的特点是一种硫醇组(-SH)附于一个硫苯环,这是一个五人组成的芳香环,含有硫磺.三氟甲基苯氧组(-O-CF3)是一种强大的电脱盐替代结构,它能够极大地影响化合物的再活动性和特性.氟素原子的存在会增强化合物的脂性,并可能影响其溶解性.此外,三氟氧氧基组可能具有独特的电子特性,使之在各种化学应用中有用,包括作为有机合成或药物开发中的潜在建筑块.该化合物的结构表明材料科学和农用化学化学中的潜在应用,其中硫磺和氟化合物的结合可导致有趣的化学行为.应当观测到安全性和处理防范措施,因为该化合物的存在可能具有反应性,因为该混合物具有反应力.
相似化合物
456-55-3 220239-66-7 2546-45-4物理性质
MSDS等安全信息
- GHS象形图
- GHS符号GHS07;
注释: Exclamation mark - 危险类别急性毒性 类别4(吸入)
急性毒性 类别4(经皮)
急性毒性 类别4(经口)
特定目标器官毒性 - 单次接触 类别3
皮肤腐蚀/刺激 类别2
严重眼刺激 类别2
急性毒性 类别2(吸入)
急性毒性 类别3(经皮)
急性毒性 类别3(经口) - 警示词Warning(警告)
- 危险描述H332 |吸入有害.
H312 |皮肤接触有害.
H302 |吞咽有害.
H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
H330 |吸入致命.
H311 |皮肤接触会中毒.
H301 |吞咽会中毒. - 防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361+P364-P362+P364-P405-P501
- 危险等级6.1
- UN编号2810.0
- 危险品标志Xi,Xn
- 风险等级Harmful/Stench/Air Sensitive/Keep Cold
- 包装等级Ⅲ
- 安全声明26-36-36/37
- 危险类别码36/37/38-20/21/22-43
欧盟法规
ECHA物质C&L通报上下游产品
CAS号94108-56-2 4-(三氟甲氧基)苯磺酰氯 | CAS号7440-66-6 锌标准溶液 | CAS号828-27-3 4-三氟甲氧基苯酚合成工艺路线路线简述
- 合成目标产物 4-(Trifluoromethoxy)Thiophenol 主要起始原料 4-(Trifluoromethoxy)Benzenesulfonyl Chloride And Zinc
- (文献来源)合成步骤主要原料 4-(Trifluoromethoxy)Benzenesulfonyl Chloride 和 Zinc
📜对三氟甲氧基苯酚置于劳森试剂体系中,用 四氢呋喃 用作溶剂,化学反应生成4-(三氟甲氧基)苯-1-硫醇
参考文献:N-Acylhydrazones As Inhibitors Of Pde10A
标题:N-Acylhydrazones As Inhibitors Of Pde10A
摘要:Cyclic Nucleotide Phosphodiesterases (Pdes) Are Represented By A Large Superfamily Of Enzymes. A Series Of Hydrazone-Based Inhibitors Was Synthesized And Shown To Be Novel,Potent,And Selective Against Pde10A. Optimized Compounds Of This Class Were Efficacious In Animal Models Of Schizophrenia And May Be Useful For The Treatment Of This Disease. (C) 2011 Elsevier Ltd. All Rights Reserved.
Doi:10.1016/j.Bmcl.2011.05.100
海关参考信息
- 2905110000-甲醇
2908199090-其他酚的卤化衍生物
2908999090-其他酚的硝化衍生物
2918290000-其他含酚基羧酸 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:WO-2024068976-A1
优先权日:2022-09-29
标 题 :Azole derivatives as shp2 inhibitors
发明人：PETROCCHI ALESSIA; MONTALBETTI CHRISTIAN; DI FABIO ROMANO; CIAMMAICHELLA ALINA; ROSSETTI ILARIA
权利人:IRBM S P A; C N C C S S C A R L COLLEZIONE NAZ DEI COMPOSTI CHIMICI E CENTRO SCREENING
摘要:The present invention relates to new compounds capable of inhibiting the activity of SHP2 phosphatase. Compounds of the invention can be used for the treatment of disorders associated with SHP2 deregulation. The present invention also relates to pharmaceutical compositions containing said compounds and to their method of synthesis.
专利号:US-9925177-B2
优先权日:2015-01-22
标题:4-methylsulfonyl-substituted piperidine urea compounds
发明人：OSLOB JOHAN; AUBELE DANIELLE; KIM JAE; MCDOWELL ROBERT; SONG YONGHONG; SRAN ARVINDER; ZHONG MIN
权利人:MYOKARDIA INC
摘要:The present invention provides novel 4-methylsulphone-substituted piperidine urea compounds that are useful for the treatment of dilated cardiomyopathy (DCM) and conditions associated with left and/or right ventricular systolic dysfunction or systolic reserve. The synthesis and characterization of the compounds is described, as well as methods for treating DCM and other forms of heart disease.
专利号:US-11123337-B2
优先权日:2015-01-22
标题 :4-methylsulfonyl-substituted piperidine urea compounds
发明人：OSLOB JOHAN; AUBELE DANIELLE; KIM JAE; MCDOWELL ROBERT; SONG YONGHONG; SRAN ARVINDER; ZHONG MIN
权利人:MYOKARDIA INC
摘要:The present invention provides novel 4-methylsulphone-substituted piperidine urea compounds that are useful for the treatment of dilated cardiomyopathy (DCM) and conditions associated with left and/or right ventricular systolic dysfunction or systolic reserve. The synthesis and characterization of the compounds is described, as well as methods for treating DCM and other forms of heart disease.
