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对氟肉桂酸置于硫酸氢铵,Encp-R299K Variant体系中,化学反应 22.0H,以95%的收率获得
参考文献:细菌氨裂解酶 Encp:一种用于合成非天然氨基酸的可调生物催化剂
标题:细菌氨裂解酶 Encp:一种用于合成非天然氨基酸的可调生物催化剂
摘要:I类裂解酶家族的酶催化氨向丙烯酸芳基酯的不对称加成,产生作为产物的高价值氨基酸.最近的例子包括使用苯丙氨酸氨裂解酶 (Pal),单独使用或作为去消旋级联的途径(分别提供 (S)-或 (R)-α-苯丙氨酸衍生物),以及真核苯丙氨酸氨基变位酶 (Pam) (R)-β-产物的合成.在此,我们介绍了对来自 Streptomyces Maritimus 的另一个家族成员 Encp 的研究,从而扩展了生物催化工具箱并能够生产缺失的 (S)-β-异构体.发现 Encp 将一系列芳基丙烯酸酯转化为 (S)-α-和 (S)-β-芳基丙氨酸的混合物,其区域选择性与每个底物环上的吸电子/供电子基团的强度相关.野生型酶的低区域选择性通过基于结构的合理设计得到解决,以产生三种对α-或β-产物具有改变偏好的变体.通过检查各种生物催化剂/底物组合,证明可以调整反应的胺化模式,以根据需要实现 99:1 和 1:99 之间的
Doi:10.1021/jacs.5B07326

专利信息

专利号:US-9574189-B2
优先权日:2005-12-01
标题:Enzymatic encoding methods for efficient synthesis of large libraries
发明人：FRANCH THOMAS; LUNDORF MIKKEL DYBRO; JACOBSEN SØREN NYBOE; OLSEN EVA KAMPMANN; ANDERSEN ANNE LEE; HOLTMANN ANETTE; HANSEN ANDERS HOLM; SØRENSEN ANDERS MALLING; GOLDBECH ANNE; DE LEON DAEN; KALDOR DITTE KIEVSMOSE; SLØK FRANK ABILDGAARD; HUSEMOEN GITTE NYSTRUP; DOLBERG JOHANNES; Jensen Kim Birkebæ; PEDERSEN LENE; NØRREGAARD-MADSEN MADS; GODSKESEN MICHAEL ANDERS; GLAD SANNE SCHRØDER; NEVE SØREN; THISTED THOMAS; KRONBORG TINE TITILOLA AKINLEMINU; SAMS CHRISTIAN KLARNER; FELDING JAKOB; FRESKGÃ…RD PER-OLA; GOULIAEV ALEX HAAHR; PEDERSEN HENRIK
权利人:FRANCH THOMAS; LUNDORF MIKKEL DYBRO; JACOBSEN SØREN NYBOE; OLSEN EVA KAMPMANN; ANDERSEN ANNE LEE; HOLTMANN ANETTE; HANSEN ANDERS HOLM; SØRENSEN ANDERS MALLING; GOLDBECH ANNE; DE LEON DAEN; KALDOR DITTE KIEVSMOSE; SLØK FRANK ABILDGAARD; HUSEMOEN GITTE NYSTRUP; DOLBERG JOHANNES; Jensen Kim Birkebæ; PEDERSEN LENE; NØRREGAARD-MADSEN MADS; GODSKESEN MICHAEL ANDERS; GLAD SANNE SCHRØDER; NEVE SØREN; THISTED THOMAS; KRONBORG TINE TITILOLA AKINLEMINU; SAMS CHRISTIAN KLARNER; FELDING JAKOB; FRESKGÃ…RD PER-OLA; GOULIAEV ALEX HAAHR; PEDERSEN HENRIK; NUEVOLUTION AS
摘要:Disclosed is a method for obtaining a bifunctional complex comprising a molecule linked to a single stranded identifier oligonucleotide, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is a) reacted at the chemical reaction site with one or more reactants, and b) reacted enzymatically at the priming site with one or more tag(s) identifying the reactant(s).

专利号:US-11702652-B2
优先权日:2005-12-01
标题:Enzymatic encoding methods for efficient synthesis of large libraries

专利号:US-2009264300-A1
优先权日:2005-12-01
标题 :Enzymatic encoding methods for efficient synthesis of large libraries

专利号:US-2020216836-A1
优先权日:2005-12-01
标题 :Enzymatic encoding methods for efficient synthesis of large libraries

专利号:EP-1957644-B1
优先权日:2005-12-01
标 题 :Enzymatic encoding methods for efficient synthesis of large libraries

专利号:US-2019330618-A1
优先权日:2005-12-01
标题 :Enzymatic encoding methods for efficient synthesis of large libraries