CAS: 1450-63-1; 1,1,4,4-Tetraphenyl-1,3-Butadiene

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📜1,1-二苯乙烯置于hg(II) Trifluoroacetate,三乙胺,Palladium Dichloride体系中,用 苯 用作溶剂,化学反应 0.5H,以88%的收率获得1,1,4,4-甲苯基-1,3-丁二烯
参考文献:One-Pot Synthesis Of Oligomeric Aryl-Substituted Ppv Analogs With Extended π-Conjugation
标题:One-Pot Synthesis Of Oligomeric Aryl-Substituted Ppv Analogs With Extended π-Conjugation
摘要:我们研究了一种概念新颖的方法,即从相应的二元单体(nâ = â 1)一步法合成具有 Hâ[chc(Ar)âc6H4âc(Ar)Ch]Nâh (nâ = â 2,4)型扩展ï-共轭的低聚聚聚苯乙烯(ppv,â[c6H4âchch]â)类似物.通过重复三氟乙酸汞衍生物 Hâ[chc(Ar)âc6H4âc(Ar)Ch]Nâhgco2Cf3 (nâ =â 1,2)的连续制备及其在 Pdcl2 存在下的偶联,以高产率实现了低聚物化.这种方法的可行性体现在直接从相应的单体一锅制备出了几种四聚体.
Doi:10.1039/a905710B

专利信息

专利号:WO-2012016973-A1
优先权日:2010-08-02
标 题:Invention related to contact allergens
发明人：SCHMIDT MARC; GOEBELER MATTHIAS; BADRINARAYANAN RAGHAVAN
权利人:TRANSMIT GMBH; SCHMIDT MARC; GOEBELER MATTHIAS; BADRINARAYANAN RAGHAVAN
摘要:The problem of the underlying invention is to foresee a new method and a new class of substances to treat and or reduce hypersensivity (CHS) with mammals, especially humans to nickel, especially Ni 2+ . Surprisingly it was found, that the site-specific h TLR4 inhibition as potential strategy for therapeutic intervention without affecting vital immune responses. Here we demonstrate that Ni 2+ induces an inflammatory response via direct activation of human Toll-like receptor 4 (hTLR4). Remarkably, Ni 2+ induces TLR4 activation is species-specific since mouse TLR4 (mTLR4) is incapable to generate this response. Studies with mutant TLR4 proteins revealed a requirement of the non-conserved histidines 456 and 458 of h TLR4 for activation by Ni 2+ but not by the natural ligand LPS. Accordingly, transgenic h TLR4 expression in Tlr4 -deficient mice allowed efficient sensitization to Ni 2+ and elicitation of CHS. Allergies to nickel (Ni 2+) are the most frequent cause of contact hypersensitivity (CHS) in industrialized countries. Both a T lymphocyte-specific signal and a proinflammatory signal are required for efficient CHS development. Here we demonstrate that Ni 2+ induces an inflammatory response via direct activation of human Toll-like receptor 4 (hTLR4). Remarkably, Ni 2+ induced TLR4 activation is species-specific since mouse TLR4 (m TLR4) is incapable to generate this response. Studies with mutant TLR4 proteins revealed a requirement of the non-conserved histidines 456 and 458 of h TLR4 for activation by Ni2+ but not by the natural ligand LPS. Accordingly, transgenic h TLR4 expression in Tlr4 -deficient mice allowed efficient sensitization to Ni 2+ and elicitation of CHS. Our data implicate site-specific h TLR4 inhibition as potential strategy for therapeutic intervention without affecting vital immune responses. Furthermore it is shown that hypersensitivity-related inflammatory response via direct activation of human Toll-like receptor 4 (h TLR4) is not only induced by nickel but also by cobalt (Co 2+ ). Moreover, the invention surprisingly describes synthesis of truncated h TLR4 molecules (s-h TLR4) missing the transmembrane domain and the C-terminal part of the protein that are applicable in a method for identification of substances to treat and or reduce hypersensitivity (CHS) or sepsis with mammals by inhibition of h TLR4 activation.

专利号:US-2007069198-A1
优先权日:2003-09-29
标题:Synthesis of phenyl-substituted fluoranthenes by a diesel-alder reaction and the use thereof

专利号:JP-2007507449-A
优先权日:2003-09-29
标题:Synthesis of phenyl-substituted fluoranthene by Diels-Alder reaction and its use

专利号:DE-10345583-A1
优先权日:2003-09-29
标 题 :Synthesis of phenyl-substituted fluoranthenes by Diels-Alder reaction and their use

专利号:US-7906225-B2
优先权日:2003-09-29
标 题:Synthesis of phenyl-substituted fluoranthenes by a diesel-alder and the use thereof
发明人：DOETZ FLORIAN; SCHWALM REINHOLD; ROESCH JOACHIM
权利人:BASF AG
摘要:A substituted fluoranthene, a light emitting layer including the substituted fluoranthene, a diode including the substituted fluoranthene, and a visual display unit including the substituted fluoranthene.

专利号:WO-2005033051-A1
优先权日:2003-09-29
标 题:Synthesis of phenyl-substituted fluoranthenes by a diesel-alder reaction and the use thereof