CAS: 129-43-1; 1-Hydroxyanthraquinone

该化合物是炭疽家族的有机化合物,其特征是炭疽结构中附属的氢氧基(OH),由三根有引信的苯乙烯环组成,该化合物一般是红褐色固体,以其在染色和颜料生产中的动态颜色和潜在用途而著称,在乙醇和丙酮等有机溶剂中溶解,但水溶性有限.1-Hydroxyantraquinone具有很强的紫外线-视觉吸收作用,在各种分析应用中有用,包括染色和光化学研究.此外,已对其潜在的生物活动进行了调查,包括抗微生物和抗癌特性.然而,在处理该化合物时应采取安全防范措施,因为这可能对接触健康造成风险.

结构式图片

相似化合物

117-12-4 117-10-2 81-64-1

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

pyridine 1-nitroanthraquinone tetrachloromethane 1-acetoxy-5-hydroxy-9,10-dioxo-1,4,4a,9,9a,10-hexahydroanthracene 1-chloroanthracene-9,10-dione 1,2-dihydroxy-9,10-anthracenedione 1-Hydroxy-anthrahydr°Chinon 4-chloro-1-hydroxyanthraquinone

合成工艺路线路线简述

  • 82-34-8 = 129-43-1 + 82-28-0 + 82-45-1
    反应条件:1.1 Solvents: Dimethylformamide
    标题:Reaction Of 1-Nitroanthraquinone With Hexamethylenetetramine
    作者:Galich,L. V.; Et Al
    参考文献:Zhurnal Organicheskoi Khimii 日期:1986 卷标:22(12) 页码:2619-20

海关参考信息

专利信息


专利号:US-6531591-B1
优先权日:1999-07-07
标 题 :Synthesis of stable quinone and photoreactive ketone phosphoramidite reagents for solid phase synthesis of photoreactive-oligomer conjugates
发明人:FENSHOLDT JEF
权利人:EXIQON AS
摘要:Quinone phosphoramidite reagents as well as photoreactive ketone phosphoramidite reagents, such as anthraquinone phosphoramidite reagents and benzophenone phosphoramidite reagents were synthesized and used for the solid phase synthesis of photoreactive-oligonucleotide conjugates. These phosphoramidite reagents are stable, suitable for large-scale synthesis and designed for automated solid phase synthesis of oligomers terminating in a photoreactive moiety.

专利号:EP-1202998-B1
优先权日:1999-07-07
标 题 :Synthesis of stable quinone and photoreactive ketone phosphoramidite reagents for solid phase synthesis of photoreactive-oligomer conjugates
发明人:FENSHOLDT JEF
权利人:EXIQON AS
摘要:Quinone phosphoramidite reagents as well as photoreactive ketone phosphoramidite reagents, such as anthraquinone phosphoramidite reagents and benzophenone phosphoramidite reagents were synthesized and used for the solid phase synthesis of photoreactive-oligonucleotide conjugates. These phosphoramidite reagents are stable, suitable for large-scale synthesis and designed for automated solid phase synthesis of oligomers terminating in a photoreactive moiety.

专利号:US-5424421-A
优先权日:1990-07-17
标 题:Synthesis of carminic acid and principal intermediates
发明人:TYMAN JOHN H P; FIECCHI ALBERTO
权利人:EUROP COLOUR PLC
摘要:The invention relates to the synthesis of 6-deoxykermesates, 6-deoxykermesic acid, and carminic acid, based on a reaction of a 2-halogenonapthazarin with a bis-trimethylsilyl-diene.

专利号:US-2022378721-A1
优先权日:2019-10-24
标 题 :Protein kinase inhibitors and use thereof for treatment of neurodegenerative diseases
发明人:SRIDHAR JAYALAKSHMI; BRATTON MELYSSA; GOYAL NAVNEET; JHA VISHWAJEET; SCHROEDER RICHARD
权利人:XAVIER UNIV OF LOUISIANA
摘要:The present disclosure relates to compounds that act as protein kinase inhibitors, especially CK1δ and/or CK1ε inhibitors, which can be used to treat a serine threonine kinase-dependent disease and condition, such as neurodegenerative diseases like Alzheimer's Disease, and the synthesis of the same. Further, the present disclosure teaches the utilization of such compounds in a treatment for neurodegenerative diseases, including Alzheimer's disease.

专利号:US-4739062-A
优先权日:1985-07-09
标题:Method of producing paraquinones
发明人:BIGI FRANCA; CASIRAGHI GIOVANNI; CASNATI GIUSEPPE; SARTORI GIOVANNI
权利人:CONSIGLIO NAZIONALE RICERCHE
摘要:A new widely-applicable method has been found for synthesis of 9,10-anthraquinones and similar chemical compounds of wide use in industry and pharmacology, by reacting suitable aromatic substrates with activated dicarboxylic acids (more particularly dichlorides) in the presence of metal halides. The special characteristics of the reaction are the good yields, high selectivity, the possibility of operating in a single reactor and the use of starting compounds which are cheap and easily available on the market.

专利号:WO-2005059046-A1
优先权日:2003-12-10
标 题:Improved process for the production of printing inks
发明人:NIVEN STUART COOK; WILCOX JOYCE
权利人:CIBA SC HOLDING AG; NIVEN STUART COOK; WILCOX JOYCE
摘要:Process for preparing a polar organic solvent-based printing ink composition which comprises reacting a dye precursor of a cationic indole dye with an organic non-abietyl resin acid, preferably an organic sulfonic acid, in a polar organic solvent suitable for printing inks or in the printing ink medium. The synthesis of the coloured ink via an in-situ generation of the cationic dye offers many procedural advantages such the avoidance of isolation and purification steps for the dye. The printing inks obtained show for example high colour strength and excellent rheological properties and can be used in publication or packaging gravure flexographic, lithographic or letterpress printing processes.
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主要参考文献


1: Wang J, Qu Q, Liu X, Cui W, Yu F, Chen X, Xing X, Zhou Y, Yang Y, Bello- Onaghise G, Chen X, Li X, Li Y. 1-Hydroxyanthraquinone exhibited antibacterial activity by regulating glutamine synthetase of Staphylococcus xylosus as a virulence factor. Biomed Pharmacother. 2020 Mar;123:109779. doi: 10.1016/j.biopha.2019.109779. Epub 2020 Jan 6. 100(1):230-235. doi: 10.5740/jaoacint.16-0067. 8(2):191-195. doi: 10.1021/acsmedchemlett.6b00398.
4: Wianowska D. Hydrolytical instability of hydroxyanthraquinone glycosides in pressurized liquid extraction. Anal Bioanal Chem. 2014 May;406(13):3219-27. doi: 10.1007/s00216-014-7744-5. Epub 2014 Mar 22.
5: Meng QX, Roubin RH, Hanrahan JR. Ethnopharmacological and bioactivity guided investigation of five TCM anticancer herbs. J Ethnopharmacol. 2013 Jun 21;148(1):229-38. doi: 10.1016/j.jep.2013.04.014. Epub 2013 Apr 23. 45(3):1001-7. doi: 10.1016/j.ejmech.2009.11.042. Epub 2009 Nov 26. 23(14):1322-9. doi: 10.1080/14786410902753138. 393(1):64-71. doi: 10.1016/j.scitotenv.2007.11.036. Epub 2008 Jan 24. 24(8):1984-93. doi: 10.1897/04-310r.1. 232(2):272-8. doi: 10.1016/j.canlet.2005.02.044. 122(3):34305. doi: 10.1063/1.1829991. Erratum in: J Chem Phys. 2005 Aug 1;123(5):059902. 23(5):335-44. doi: 10.1080/10915810490517072. 43(8):2654-71. doi: 10.1021/ic035370d. 32(4):206-12. doi: 10.1002/mc.10014. 7(3):501-8. doi: 10.3892/or.7.3.501. 38(4):298-301. doi: 10.1076/1388-0209(200009)3841-AFT298. 24(3):232-7. doi: 10.1002/(sici)1098-2744(199903)24:3<232::aid- mc10>3.0.co;2-m. 20(4):389-93. 97(1):75-82. doi: 10.1016/0304-3835(95)03966-z. 328(2):183-91. doi: 10.1016/0027-5107(95)00003-2.

合成参考文献


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参考文献:10.1007/s00253-019-09972-z
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