CAS: 110-16-7; Maleic Acid

• 英文名称Maleic Acid
• 中文名称顺丁烯二酸
• IUPAC名称maleic acid
• 其它别名马来酸; 顺丁烯二酸
• CAS编号110-16-7
• MFCD编号:MFCD00063177
• EINECS号:203-742-5
• 分子式:C4H4O4
• 分子量:116.07
• 产品CID: 139856
• 产品分类有机原料→分子砌块→脂肪链类化合物

• 相似结构搜索
• 产品信息参考;;;;
• InChIKey: VZCYOOQTPOCHFL-UPHRSURJSA-N
• InChI=1S/C4H4O4/c5-3(6)1-2-4(7)8/h1-2H,(H,5,6)(H,7,8)/b2-1-…
• 计算化学: 氢键受体数2.0氢键供体数2.0可旋转键数2.0

相似化合物

物理性质

• 熔点130-135 °C
• 沸点275 °C at 760 mmHg
• 闪点127°C
• 密度1.5±0.1 g/cm3
• pKa:2.39±0.25(预测)
• PSA:74.6
• LogP:-0.2882
• 折射率1.526
• 蒸汽压0.0±1.7 mmHg at 25°C
• 溶解性水中的溶解度为478.8克/升
• 敏感性1.禁止与碱类，氧化剂、还原剂接触。2.顺酸有毒，刺激皮肤和黏膜，引起结膜、角膜红肿以及视力减退，甚至失明。皮肤接触液态酸，可致烧伤。大鼠经口LD50为708mg/kg。操作过程中要穿戴好防护用品，设备要密闭，防止跑冒滴漏，现场应有良好的通风条件。沾染顺酸后要用大量清水冲洗。着火时要用水或CO2喷雾灭火器，不能使用NaHCO3灭火器，因其易造成顺酸急速分解。3. 存在于烟叶中。4. 强烈的刺激性。
• 外观形态白色固体
• 储存条件2-8°C
• 产品应用制取农药马拉松,达净松,富马酸,不饱和聚酯树脂,染色助剂以及油脂防腐剂等.
• 性质描述单斜晶系无色结晶.熔点为130-130.5°C.约在138°C时分解.溶于水,乙醇和丙酮,不溶于苯.顺丁烯二酸在自然界中不存在,与反丁烯二酸互为顺反异构体.顺丁烯二酸不如反丁烯二酸稳定,温度高于熔点时部分转变为反丁烯二酸.加热至160°C即失水形成顺丁烯二酸酐,若用化学脱水剂,可在较低温度下脱水.顺丁烯二酸相对密度为1.590(20/4°C).有恶劣的酸气味,味涩.

MSDS等安全信息

• GHS象形图
• GHS符号GHS07;
  注释: Exclamation mark
• 危险类别急性毒性 类别4(经皮)
  急性毒性 类别4(经口)
  特定目标器官毒性 - 单次接触 类别3
  皮肤腐蚀/刺激 类别2
  严重眼刺激 类别2
  皮肤致敏 类别1
  皮肤腐蚀 类别1B
  严重眼损伤 类别1
  皮肤致敏 类别1B
  水生慢性毒性 类别3
  皮肤致敏 类别1A
  急性毒性 类别3(经口)
  特定目标器官毒性-重复接触 类别2
  皮肤腐蚀 类别1C
  水生慢性毒性 类别2
  皮肤腐蚀 类别1
  急性毒性 类别4(吸入)
  金属腐蚀物 类别1
  严重眼刺激 类别2A
  呼吸道致敏 类别1
• 警示词Warning(警告)
• 危险描述H312 |皮肤接触有害.
  H302 |吞咽有害.
  H335 |可能引起呼吸道刺激.
  H315 |造成皮肤刺激.
  H319 |造成严重眼刺激.
  H317 |可能引起皮肤过敏反应.
  H314 |造成严重皮肤灼伤和眼损伤.
  H318 |造成严重眼损伤.
  H412 |对水生生物有害并具有长期持续影响.
  H301 |吞咽会中毒.
  H373 |长期或反复接触可能损害器官.
  H411 |对水生生物有毒并具有长期持续影响.
  H332 |吸入有害.
  H370 |损害器官.
  H290 |可能对金属造成腐蚀.
  H334 |吸入可能引起过敏或哮喘症状或呼吸困难.
• 防范说明P261-P264-P270-P271-P272-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
• 危险等级8
• UN编号1759.0
• 危险品标志Xn:Harmful
• 包装等级Ⅲ
• 安全声明S26-S28-S37
• 危险类别码R22,R36/37/38
• WGK Germany1

欧盟法规

上下游产品

合成工艺路线路线简述

• 合成目标产物 Maleic Acid 主要起始原料 Acetylenedicarboxylic Acid
• 330942-05-7 + 110-16-7 = 110-16-7 + 330942-05-7
  反应条件:1.1 Solvents: Ethanol,Water; 2.5 H,Rt
  标题:Preparing Method And Application Of Betrixaban Intermediate
  参考文献:China]
  
  330942-05-7 + 110-16-7 = 110-16-7 + 330942-05-7
  反应条件:1.1 Solvents: Ethanol,Water; Rt -> 70 °C; 70 °C; 2 H,70 °C -> Reflux
  标题:Synthetic Process Of Betrixaban
  作者:Zhao,Hua; Chu,Qian-Qian; Wang,Hui; Shang,Zhen-Hua
  参考文献:Zhongguo Xinyao Zazhi 日期:2014 卷标:23(24) 页码:2902-2904]
  
  = 110-16-7 + 330942-05-7 [标题:Reaction Conditions
  标题:Improved Process For Preparation Of Betrixaban Maleate
  参考文献:India]
  
  = 110-16-7 + 330942-05-7 [标题:Reaction Conditions
  标题:Unit Dose Formulations And Methods Of Treating Thrombosis With An Oral Factor Xa Inhibitor,And In Vitro Assay For Antithrombotic Activity Prediction
  参考文献:World Intellectual Property Organization]
  
  = 110-16-7 + 330942-05-7 [标题:Reaction Conditions
  标题:Methods For Preparing Pharmaceutical Salts Of A Factor Xa Inhibitor
  参考文献:World Intellectual Property Organization]
  
  9005-53-2 = 110-16-7 + 110-17-8 + 141-82-2 + 6915-15-7 + 87-69-4 + 110-15-6 + 144-62-7
  反应条件:1.1R:H2So4,R:H2O2
  标题:Electrochemical Conversion Of Lignin To Short-Chain Carboxylic Acids
  作者:By Sun,Shirong Et Al
  参考文献:Green Chemistry 日期:2023 卷标:25(8) 页码:3127-3136]
  
  9004-34-6 = 110-16-7 + 110-17-8 + 141-82-2 + 79-14-1 + 110-15-6 + 144-62-7
  反应条件:1.1R:R:O2,S:H2O,175°C,30 Bar
  标题:Lignin Alkaline Oxidation Using Reversibly-Soluble Bases
  作者:By Kruger,Jacob S. Et Al
  参考文献:Green Chemistry 日期:2022 卷标:24(22) 页码:8733-8741]
  
  = 110-16-7 + 65-85-0 + 100-52-7 + 144-62-7
  反应条件:1.1R:O2,C:Mn,C:Al2O3,C:Ag
  标题:Probing The Effects Of Plasma-Induced Surface Species In Ring-Opening Process Of Toluene Decomposition Via Plasma-Excited Tpd And In Situ Drifts
  作者:By Sun,Yuhai Et Al
  参考文献:Journal Of Cleaner Production 日期:2022 卷标:371 页码:133332]
  
  = 110-16-7 + 97529-85-6 + 26447-28-9
  反应条件:1.1 Reagents: Perchloric Acid Catalysts: Palladium
  标题:Insight Into The Oxidation Mechanism Of Furanic Compounds On Pt(111)
  作者:Mark,Lesli O.; Agrawal,Naveen; Roman,Alex M.; Holewinski,Adam; Janik,Michael J.; Et Al
  参考文献:Acs Catalysis 日期:2019 卷标:9(12) 页码:11360-11370]
  
  88150-42-9 + 110-16-7 = 110-16-7 + 88150-42-9
  反应条件:1.1 Solvents: Ethyl Acetate; 3 H,Rt
  标题:Synthesis Of Amlodipine Maleate
  作者:Xu,Feng; Et Al
  参考文献:Anhui Huagong 日期:2013 卷标:39(3) 页码:23-24]
  
  330942-01-3 + 110-16-7 = 110-16-7 + 330942-05-7
  反应条件:1.1 Reagents: Magnesate(1-),Dichloro(1-Methylethyl)-,Lithium (1:1) Solvents: Tetrahydrofuran; 2 H,0 - 10 °C; 1 - 2 H,0 - 10 °C1.2 Reagents: Hydrochloric Acid Solvents: Water; Ph 1.5 - 2.5,0 - 30 °C; 1 H,Rt1.3 Reagents: Potassium Carbonate Solvents: Methanol,Dichloromethane,Water; 30 Min,Rt1.4 Solvents: Ethanol,Water; 1 H,Rt
  标题:Process For The Preparation Of Betrixaban And Its Salts
  参考文献:India]
  
  330942-05-7 + 110-16-7 = 110-16-7 + 330942-05-7
  反应条件:1.1 Solvents: Acetone; 30 Min,55 - 60 °C
  标题:Process For Preparing Amorphous Form Of Betrixaban Maleate Containing Solvent And Antisolvent
  参考文献:India]
  
  = 110-16-7 + 330942-05-7 [标题:Reaction Conditions
  标题:Process For The Preparation Of N-(5-Chloropyridin-2-Yl)-2[4-(N,N-Dimethylcarbamimidoyl)-Benzoylamino]-5-Methoxybenzamide And Its Pharmaceutically Acceptable Salts
  参考文献:India]
  
  = 110-16-7 + 330942-05-7 [标题:Reaction Conditions
  标题:A Process For Preparation Of Betrixaban Hydrochloride And Betrixaban Maleate Salt
  参考文献:India]
  
  = 110-16-7 + 330942-05-7 [标题:Reaction Conditions
  标题:Method For Preparing Betrixaban Maleate
  参考文献:China]
  
  = 110-16-7 + 330942-05-7 [标题:Reaction Conditions
  标题:Preparation Method Of Betrixaban Maleate
  参考文献:China]
  
  = 110-16-7 + 330942-05-7 [标题:Reaction Conditions
  标题:Methods Of Synthesizing Pharmaceutical Salts Of A Factor Xa Inhibitor
  参考文献:United States]
  
  = 110-16-7 + 330942-05-7 [标题:Reaction Conditions
  标题:Crystalline Forms Of A Factor Xa Inhibitor
  参考文献:World Intellectual Property Organization]
  
  = 110-16-7 + 330942-05-7 [标题:Reaction Conditions
  标题:Process For Preparation Of Betrixaban And Maleate Salt As Factor Xa Inhibitors
  参考文献:World Intellectual Property Organization]
  
  = 110-16-7 + 330942-05-7 [标题:Reaction Conditions
  标题:Pharmaceutical Salt And Polymorph Of Factor Xa Inhibitor
  参考文献:World Intellectual Property Organization]
  
  90445-12-8 = 110-16-7 + 88150-42-9
  反应条件:1.1 Reagents: Triethylamine,Hydroxyamine Hydrochloride Solvents: Isopropanol,Water; 5 H,Reflux2.1 Solvents: Ethyl Acetate; 3 H,Rt
  标题:Synthesis Of Amlodipine Maleate
  作者:Xu,Feng; Et Al
  参考文献:Anhui Huagong 日期:2013 卷标:39(3) 页码:23-24]
  
  14205-39-1 + 89-98-5 = 110-16-7 + 88150-42-9
  反应条件:1.1 20 H,80 °C2.1 Reagents: Triethylamine,Hydroxyamine Hydrochloride Solvents: Isopropanol,Water; 5 H,Reflux3.1 Solvents: Ethyl Acetate; 3 H,Rt
  标题:Synthesis Of Amlodipine Maleate
  作者:Xu,Feng; Et Al
  参考文献:Anhui Huagong 日期:2013 卷标:39(3) 页码:23-24

海关参考信息

• 2901210000-乙烯
  2901220000-丙烯
  2912110000-甲醛
  2912120000-乙醛
• 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
• 详情请参考：📖 海关编码查询和海关进出口税则

专利信息

其他信息查阅

• ➥ 象形图和危险代码
• ➥ 防范代码详解
• ➥ 危险代码说明
• ➥ Globally Harmonized System
• ➥ REACH监管