CAS: 107807-39-6; 2,3-Dihydro-6-Isothiocyanato-1,4-Phthalazinedione

上下游产品

thiophosgene isoluminol

📜硫光气,4-氨基邻苯二甲酰肼置于三乙胺体系中,用 N,N-二甲基甲酰胺 用作溶剂,化学反应 24.0H,以62%的收率获得2,3-二氢-6-异硫氰基-1,4-酞嗪二酮
参考文献:Isothiocyanatoluminol As A Chemiluminescence Labeling Reagent For Amino Acids And Proteins
标题:Isothiocyanatoluminol As A Chemiluminescence Labeling Reagent For Amino Acids And Proteins
摘要:在三乙胺存在下,发光酚与硫代磷酰氯发生反应,成功合成了异硫氰基异鲁米诺(itl).优化后的条件还可用于制备异硫氰酸异鲁米诺(itil)和异硫氰酸苯酯(pi).Itl 的化学发光(cl)与发光酚相当.Itl 被用作氨基酸和牛血清白蛋白(bsa)的 Cl 标记试剂,其中 Bsa 中氨基酸残基的-Nh2 末端是标记位点.
Doi:10.1246/cl.2011.188

专利信息

专利号:US-5419966-A
优先权日:1991-06-10
标 题 :Solid support for synthesis of 3'-tailed oligonucleotides
发明人：REED MICHAEL W; MEYER JR RICH B; PETRIE CHARLES R; TABONE JOHN C
权利人:MICROPROBE CORP
摘要:A solid support for oligonucleotide synthesis has the structure where CPG represents a controlled pore glass matrix, the wavy line represents a carbon chain covalently linking the NH group with the controlled pore glass matrix, X is 2,2'-dimethoxytrityl or H, and R is alkyl, aryl, arylalkyl, heteroalkyl, or heteroaryl. The dimethoxytrityl group is removed from the solid support by treatment with acid, and the oligonucleotide is built, step-by-step in a conventional synthesizer after attachment of the 3' end of the first oligonucleotide unit to the hydroxyl function connected to the R group.

专利号:WO-9203464-A1
优先权日:1990-08-28
标题 :Solid support synthesis of 3'-tailed oligonucleotides via a linking molecule

专利号:JP-3256539-B2
优先权日:1990-08-28
标 题:Solid support synthesis of 3'-tailed oligonucleotides via linking molecules

专利号:EP-0547142-A1
优先权日:1990-08-28
标题 :Solid support synthesis of 3'-tailed oligonucleotides via a linking molecule