CAS: 103255-66-9; 2-(7-Chloro-1,8-Naphthyridin-2-yl)-3-[2-(1,4-Dioxa-8-Azaspiro[4.5]Decan-8-yl)-2-Oxoethyl]-3H-Isoindol-1-One
- 英文名称2-(7-Chloro-1,8-Naphthyridin-2-yl)-3-[2-(1,4-Dioxa-8-Azaspiro[4.5]Decan-8-yl)-2-Oxoethyl]-3H-Isoindol-1-One
- 中文名称帕秦克隆
- IUPAC名称2-(7-chloro-1,8-naphthyridin-2-yl)-3-(2-oxo-2-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)ethyl)isoindolin-1-one
- 其它别名2-(7-Chloro-1,8-naphthyridin-2-yl)-3-[2-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-2-oxoethyl]-3H-isoindol-1-one
- CAS编号103255-66-9
- MFCD编号:MFCD00864702
- FDA UNII编号:MHK03047IJ
- 分子式:C25H23ClN4O4分子量:478.93
- 产品CID: 66478
- 同类组份化合物CAS103255-66-9147724-27-4
- 产品分类原料药 → 神经系统用药 → 抗焦虑药
物理性质
- 熔点238-239°
- 沸点712.5 °C at 760mmHg
- 闪点384.7 °C
- 密度1.48g/cm3
- pKa:1.62±0.30(预测)
- PSA:84.86
- LogP:3.7432
- 折射率1.709
- 蒸汽压3.79E-20mmHg at 25°C
- 外观形态固体-粉末
- 储存条件Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
- 产品应用帕秦克隆(103255-66-9)的用途:该药是抗焦虑药.具有苯并二氮杂覃类受体的激动和拮抗的混合作用的非苯并二氮杂±嘁┪铩Ｓ纫(S)-对映异构体的活性为佳.
MSDS等安全信息
上下游产品
CAS号103255-87-4 2-(7-chloro-1,8... | CAS号2942-58-7 氰代磷酸二乙酯 | CAS号177-11-7 4-哌啶酮缩乙二醇合成工艺路线路线简述
- 合成目标产物 Pazinaclone 主要起始原料 [1(3H)-Isoindolinone-3-Yl]Acetic Acid
- (文献来源)合成步骤主要原料 [1(3H)-Isoindolinone-3-Yl]Acetic Acid
📜[1(3H)-异吲哚啉酮-3-基]乙酸置于palladium Diacetate,Potassium Carbonate,1-羟基苯并三唑,盐酸-N-乙基-N'-(3-二甲氨基丙基)碳二亚胺,三乙胺,4,5-双二苯基膦-9,9-二甲基氧杂蒽体系中,用 1,4-二氧六环,二氯甲烷 用作溶剂,化学反应生成帕秦克隆
参考文献:铜/铁催化分子间ch键的分子间氧化胺化
标题:铜/铁催化分子间ch键的分子间氧化胺化
摘要:我们报告了一种铜/铁共催化的ritter型ch活化/胺化反应,该反应可实现苄基ch键的高效和选择性分子间官能化.该新反应的特征在于简单的反应条件,容易获得的试剂和一般的底物范围,从而可以轻松合成生物学上令人感兴趣的含氮杂环.发现铜盐和铁盐在这种协同催化中起不同的作用.
Doi:10.1002/chem.201600107
专利信息
专利号:CN-107778238-A
优先权日:2016-08-29
标 题 :A new method for the synthesis of 3,4-dihydroisoquinolin-1-one and isoindoline-1-one derivatives
专利号:EP-0602814-A1
优先权日:1992-12-18
标题:Crystal forms of optically active isoindolines and their use
发明人：GOTO GIICHI; FUKUDA NAOHISA
权利人:TAKEDA CHEMICAL INDUSTRIES LTD
摘要:A crystal form of the optically active isoindoline derivative represented by the formula:n n is useful as an improving, therapeutic and preventive agent for anxiety-associated nervous symptoms, and an intermediate for synthesis thereof.
专利号:CN-114539124-A
优先权日:2022-02-28
标题 :A method for enantioselective synthesis of N,3-disubstituted-1-isoindolinone compounds
专利号:US-2014315720-A1
优先权日:2012-10-24
标 题 :Polysaccharide ester microspheres and methods and articles relating thereto
发明人：FALLON DENIS G; GARRETT THOMAS S; KIZER LAWTON E; ZAZZARA KAREN L; COMBS MICHAEL T; JOHNSON RICHARD K; DEHART GARY
权利人:CELANESE ACETATE LLC
摘要:A method for producing a polysaccharide ester microsphere may include forming a polysaccharide ester product from a polysaccharide synthesis, wherein the polysaccharide ester product comprises a polysaccharide ester and a solvent; diluting the polysaccharide ester product, thereby yielding a polysaccharide ester dope; and forming a plurality of polysaccharide ester microspheres from the polysaccharide ester dope. Suitable polysaccharides may include, but are not limited to, starch, cellulose, hemicellulose, algenates, chitosan, and any combination thereof. Esters thereof may be organic esters (e.g., acetate and the like), inorganic esters (e.g., sulfonates and the like), or combinations thereof. Further, the solids conent of the polysaccharide ester dope, in some instances, may be greater than about 16 wt %.
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Pazinaclone. A 77000, DN 2327. Drugs R D. 1999 Jul;2(1):57-9.
8: Hussein Z, Mulford DJ, Bopp BA, Granneman GR. Differences in the stereoselective pharmacokinetics of pazinaclone (DN-2327), a new anxiolytic, and its active metabolite after intravenous and oral single doses to dogs. Drug Metab Dispos. 1993 Sep-Oct;21(5):805-10.
合成参考文献
摘要:Kondo T, Yoshida K, Tanayama S. Absorption of the anxiolytic pazinaclone in animals as a criterion for species selection for toxicity studies. Arzneimittelforschung. 1996 Sep;46(9):839–43.
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