CAS: 936339-60-5; 3-(3-(4-((Pyridin-2-Yloxy)Methyl)Benzyl)Isoxazol-5-yl)Pyridin-2-Amine

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  • 1075734-33-6 = 936339-60-5
    反应条件:1.1 Reagents: Formic Acid Solvents: Toluene; -20 - -5 °C; 19 - 20 H,22 - 32 °C
    标题:Preparation Of Pyridine Derivatives Substituted With Heterocycle And Phosphonoxymethyl Group As Antifungal Agents
    参考文献:World Intellectual Property Organization]

    1075734-33-6 = 936339-60-5
    反应条件:1.1 Reagents: Formic Acid Solvents: Toluene; -5 - 20 °C; 19 - 20 H,22 - 32 °C
    标题:Process For Production Of Heterocycle-Substituted Pyridine Derivative Using Suzuki Coupling Reaction
    参考文献:World Intellectual Property Organization]

    936342-28-8 + 67346-74-1 = 936339-60-5
    反应条件:1.1 Reagents: Triethylamine Solvents: Tetrahydrofuran; 95 Min,Rt
    标题:Preparation Of Pyridine Derivatives Substituted With Heterocycle And Phosphonoamino And Antifungal Agents Containing The Same
    参考文献:World Intellectual Property Organization]

    936342-28-8 + 67346-74-1 = 936339-60-5
    反应条件:1.1 Reagents: Triethylamine Solvents: Tetrahydrofuran; 95 Min,Rt
    标题:Preparation Of Antifungal 3-{3-[4-(Pyridin-2-Yloxymethyl)Benzyl]Isoxazol-5-Yl}Pyridin-2-Ylamine And Its Salts And Crystals
    参考文献:United States]

    1075734-33-6 = 936339-60-5
    反应条件:1.1 Reagents: Formic Acid Solvents: Toluene; -5 - 20 °C; 19 - 20 H,22 - 32 °C
    标题:Preparation Of γ-Glutamylamino Substituted Pyridine Derivative As Anti-Fungal Agents
    参考文献:World Intellectual Property Organization]

    936342-28-8 + 67346-74-1 = 936339-60-5
    反应条件:1.1 Reagents: Triethylamine Catalysts: Zinc Chloride Solvents: Tetrahydrofuran; 0 °C; 18 H,Rt
    标题:An Effective Synthesis Of A (Pyridin-3-Yl)Isoxazole Via 1,3-Dipolar Cycloaddition Using Zncl2: Synthesis Of A (2-Aminopyridin-3-Yl)Isoxazole Derivative And Its Antifungal Activity
    作者:Tanaka,Keigo; Inoue,Satoshi; Murai,Norio; Shirotori,Syuji; Nakamoto,Kazutaka; Et Al
    参考文献:Chemistry Letters 日期:2010 卷标:39(10) 页码:1033-1035]

    1075734-33-6 = 936339-60-5
    反应条件:1.1 Reagents: Formic Acid; 8 H,21 - 25 °C
    标题:Heterocycle Substituted Pyridine Derivatives As Antifungal Agents And Their Preparation
    参考文献:World Intellectual Property Organization]

    1075734-33-6 = 936339-60-5
    反应条件:1.1 Reagents: Formic Acid; 8 H,21 - 25 °C
    标题:Synthesis Of Analogs Of The Gwt1 Inhibitor Manogepix (Apx001A) And In Vitro Evaluation Against Cryptococcus Spp
    作者:Trzoss,Michael; Covel,Jonathan A.; Kapoor,Mili; Moloney,Molly K.; Soltow,Quinlyn A.; Et Al
    参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2019 卷标:29(23)]

    1075734-33-6 = 936339-60-5
    反应条件:1.1 Reagents: Formic Acid; 8 H,21 - 25 °C1.2 Reagents: Tripotassium Phosphate Solvents: Tetrahydrofuran; Cooled
    标题:Preparation Of Heterocycle Substituted Pyridine Derivatives As Antifungal Agents
    参考文献:World Intellectual Property Organization]

    = 936339-60-5 [标题:Reaction Conditions
    标题:Preparation Of Pyridine Compounds Containing Heterocycle Moiety As Fungicides
    参考文献:World Intellectual Property Organization

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主要参考文献


1: Zhao M, Lepak AJ, VanScoy B, Bader JC, Marchillo K, Vanhecker J, Ambrose PG, Andes DR. In Vivo Pharmacokinetics and Pharmacodynamics of APX001 against Candida spp. in a Neutropenic Disseminated Candidiasis Mouse Model. Antimicrob Agents Chemother. 2018 Jan 29. pii: AAC.02542-17. doi: 10.1128/AAC.02542-17. [Epub ahead of print] pii: e02319-17. doi: 10.1128/AAC.02319-17. Print 2018 Mar.

合成参考文献


参考文献:10.1128/aac.00570-11
摘要:Pfaller MA, Duncanson F, Messer SA, Moet GJ, Jones RN, Castanheira M. In vitro activity of a novel broad-spectrum antifungal, E1210, tested against Aspergillus spp. determined by CLSI and EUCAST broth microdilution methods. Antimicrob Agents Chemother. 2011 Nov;55(11):5155–8.
参考文献:10.1093/jac/dkr342
摘要:Pfaller MA, Watanabe N, Castanheira M, Messer SA, Jones RN. Pre-clinical development of antifungal susceptibility test methods for the testing of the novel antifungal agent E1210 versus Candida: comparison of CLSI and European Committee on Antimicrobial Susceptibility Testing methods. Journal of Antimicrobial Chemotherapy. 2011 Aug 25;66(11):2581–4. doi: 10.1093/jac/dkr342.
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