CAS: 887324-52-9; Atorvastatin, (3S,5R)-

上下游产品

*,S*)>-5--1H-pyrrol-1-yl>-3-hydroxy-1-pentanoic acid, 2-hydroxy-1,2,2-triphenylethyl ester*,S*)-5-2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-(phenylamino)carbonyl-1H-pyrrol-1-yl-3-hydroxy-1-pentanoic acid, 2-hydroxy-1,2,2-triphenylethyl ester-1H-pyrrol-1-yl>-5-hydroxy-3-oxo-1-heptanoate1,1-dimethylethyl (R)-7-2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-(phenylamino)carbonyl-1H-pyrrol-1-yl-5-hydroxy-3-oxo-1-heptanoate

📜Tert-Butyl (6R)-6-{2-[2-(4-Fluorophenyl)-5-Isopropyl-3-Phenyl-4-(Phenylcarbamoyl)Pyrrol-1-Yl]Ethyl}-2,2-Dimethyl-1,3-Dioxane-4-Acetate置于盐酸体系中,用 四氢呋喃 作为反应溶剂,化学反应 6.0H,反应生成 阿托伐他汀杂质1
参考文献:Synthesis Of Some Impurities And/or Degradation Products Of Atorvastatin
标题:Synthesis Of Some Impurities And/or Degradation Products Of Atorvastatin
摘要:阐述了阿托伐他汀钙(3R,5R)-7-[2-(4-氟苯基)-5-异丙基-3-苯基-4-(苯基甲酰氨基)吡咯-1-基]-3,5-二羟基庚酸的一些杂质和/或降解产物的合成.这些包括其去氟类似物,相应的(3S,5S)-和(3S,5R)-对映体,阿托伐他汀内酯和一些其他潜在杂质.合成的化合物以及相应的中间体通过1H NMR,13C NMR和ms进行了表征.
DOI:10.1135/cccc20080229

专利信息

专利号:US-10647655-B2
优先权日:2016-09-02
标题:Method for the synthesis of permethrin
发明人：PULLAGURLA MANIK REDDY; NANDA KUMAR MECHERIL VALSAN; VELIGETLA MADHUSUDHANA RAO; RANGISETTY JAGADEESH BABU
权利人:BIOPHORE INDIA PHARMACEUTICALS PVT LTD
摘要:An improved method for the synthesis of substantially pure Permethrin having purity greater than 99.5% by Gas Chromatography provided. The embodiments also relates to a purification process of Permethrin by recrystallization from methanol-water mixture.

专利号:US-2012123131-A1
优先权日:2008-08-22
标 题 :Process for the preparation of strontium ranelate
发明人：PRABAHAR KOILPILLAI JOSEPH; KULKARNI PRAVIN BHALCHANDRA; PATIL PRASHANT BHASKARRAO; HIRE KAPIL RAMESH
权利人:PRABAHAR KOILPILLAI JOSEPH; KULKARNI PRAVIN BHALCHANDRA; PATIL PRASHANT BHASKARRAO; HIRE KAPIL RAMESH
摘要:The present invention relates to an improved process for the synthesis of strontium ranelate or hydrates thereof. More particularly, the present invention relates to an effective process for the preparation of a compound of formula III, which is a useful intermediate in the synthesis of strontium ranelate. n n n n n n n n n n wherein R 1 and R 2 represents substituted or unsubstituted linear or branched C 1 -C 6 alkyl group or C 3 -C 12 cyclic group.

专利号:US-11767317-B1
优先权日:2020-06-30
标题:Methods of synthesizing enantiopure deuterium-enriched pioglitazone
发明人：NAVARRE LAURE FRANÇOISE VALÉRIE; JACQUES VINCENT; BOLZE SÉBASTIEN
权利人:POXEL SA
摘要:The invention provides methods of synthesis of enantiopure deuterium enriched R-pioglitazone with structure of compound (IV), or a pharmaceutically acceptable salt thereof: n nThe invention further provides chemical intermediates useful in the synthesis of compound (IV), and methods of synthesizing those intermediates.

专利号:US-6310198-B1
优先权日:1993-01-08
标题:Extremely high purity oligonucleotides and methods of synthesizing them using dimer blocks
发明人：TANG JIN-YAN; BONGLE NANDKUMAR; GONZALEZ JOSE; SCHWARTZ WARREN E
权利人:AVECIA BIOTECHNOLOGY INC
摘要:The present invention comprises an improved method of synthesizing oligonucleotides. The method comprises employing dinucleotides (or 'dimer blocks') as the basic synthetic unit building block. The method results in extremely high purity oligonucleotides in which the N-1 content is very low, generally less than 1-2% of the full length, N, oligonucleotide. We have found that synthesis using dinucleotide phosphorothioates results in oligonucleotides having very little phosphodiester content. Furthermore, we have found that the amount of dimer required in each coupling step can be less than about 6 and is preferably about 2 equivalents. Synthesis of oligonucleotides according to the dimer block approach described herein can also be conducted without the capping step that has heretofore been deemed necessary after each coupling.

专利号:US-9512167-B2
优先权日:2010-11-30
标 题 :Optimized synthesis of pure, non-polymorphic, crystalline bile acids with defined particle size
发明人：WILHELM RUDOLF; PROELS MARKUS; FISCHER ERIK; WAENERLUND POULSEN HEIDI
权利人:WILHELM RUDOLF; PROELS MARKUS; FISCHER ERIK; WAENERLUND POULSEN HEIDI; DR FALK PHARMA GMBH
摘要:The present invention relates to a pure polymorph of Nor-UDCA or Bis-nor-UDCA, or of a pharmaceutically acceptable salt thereof. The invention further provides a pharmaceutical composition comprising the polymorph of the invention, and a method for preparing the polymorph. The invention includes the pharmaceutical use of the polymorph or of the pharmaceutical composition of the invention.

专利号:US-2014046086-A1
优先权日:2012-08-10
标题:Process for the preparation of tafluprost and intermediates thereof
发明人：WEN WEN-HSIEN
权利人:SCINOPHARM CHANGSHU PHARMACEUTICALS LTD
摘要:The present invention provides efficient, economical and environmental friendly methods for synthesis of prostaglandin analogs including tafluprost and intermediates thereof. The invention involves a selective oxidation using in situ boronate ester protection and a unique crystallization method to remove the undesired isomers of fluorinated intermediates.