CAS: 85118-05-4; (3,4-Difluorophenyl)Methanol

上下游产品

3,4 difluorobenzaldehyde methyl 3,4-difluorobenzoate (3,4-difluorobenzyl) 2,2,2-trichloroacetimidate (1S,2R,3R,5R,6S)-2-Amino-3-(3,4-difluoro-benzyloxy)-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid 2-benzyl ester 6-ethyl ester (1S,2R,3R,5R,6S)-2-Azido-3-(3,4-difluoro-benzyloxy)-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid 2-benzyl ester 6-ethyl ester

3,4-二氟苯甲酸甲酯置于sodium Tetrahydroborate,[fac-Pnn]Ruh(Pph)3(Co),氢气体系中,用 四氢呋喃 作为反应溶剂,120.0 °C,5.0 Mpa 条件下,反应 24.0H,以50%的收率获得产物3,4-二氟苯甲醇
参考文献:柔性pnn-Ru(II)配合物与nabh 4添加剂在酯的有效催化加氢中的协同相互作用†
标题:柔性pnn-Ru(II)配合物与nabh 4添加剂在酯的有效催化加氢中的协同相互作用†
摘要:催化剂负载量为含pnn的钌(II)配合物[Fac-Pnn] Ruh(pph 3)(co)(pnn = 8-(2-二苯基膦基乙基)氨基三氢喹啉)的0.001-0.05 Mol%摩尔%的nabh 4可以在温和的氢气压力下有效催化酯加氢成相应的醇.芳族和脂族酯都可以以高的ton或tof值转化.使用dft计算和标记实验进行的机理研究突显了nabh 4在催化中的协同作用,而催化活性物质已被确定为反式-二氢化物[Mer-Pn Hn] Ruh 2(co)(pn H N = 8-(2-二苯基膦乙基)氨基三氢喹啉).pn H N-钌物种的立体结构极大地影响了催化剂的活性,实际上,顺式-二氢异构体[Fac-Pn H N] Ruh 2(co)不能催化酯的氢化,直到配体重组为止发生以得到反式异构体.
DOI:10.1039/c6Cy02413K

专利信息

专利号:CN-111303179-A
优先权日:2020-03-17
标 题:Synthesis of a Class of Norcantharidin Carboxylic Acid Difluorobenzyl Esters and Its Antitumor Application

专利号:CN-111303179-B
优先权日:2020-03-17
标 题 :Synthesis of norcantharidin carboxylic acid difluoro benzyl ester and anti-tumor application thereof

专利号:US-2008176865-A1
优先权日:2005-06-15
标 题:Substituted arylpyrazoles
发明人：BILLEN DENIS; BOYLE JESSICA; CRITCHER DOUGLAS JAMES; GETHIN DAVID MORRIS; HALL KIM THOMAS; KYNE GRAHAM MICHAEL
权利人:PFIZER LTD
摘要:This invention relates to a range of 1-aryl-4-cyclopropylpyrazoles in which the cyclopropyl ring is substituted at the angular position, and pharmaceutically acceptable salts and solvates thereof, to compositions comprising such compounds, processes to their synthesis and their use as parasiticides.

专利号:US-7968584-B2
优先权日:2005-06-15
标 题:Substituted arylpyrazoles
发明人：BILLEN DENIS; BOYLE JESSICA; CRITCHER DOUGLAS JAMES; GETHIN DAVID MORRIS; HALL KIM THOMAS; KYNE GRAHAM MICHAEL
权利人:PFIZER; PFIZER PROD INC
摘要:This invention relates to a range of 1-aryl-4-cyclopropylpyrazoles in which the cyclopropyl ring is substituted at the angular position, and pharmaceutically acceptable salts and solvates thereof, to compositions comprising such compounds, processes to their synthesis and their use as parasiticides.

专利号:WO-2006134459-A1
优先权日:2005-06-15
标题 :Substituted arylpyrazoles
发明人：CRITCHER DOUGLAS JAMES; KYNE GRAHAM MICHAEL
权利人:PFIZER LTD; CRITCHER DOUGLAS JAMES; KYNE GRAHAM MICHAEL
摘要:This invention relates to a range of C4 substituted aryl pyrazoles of Formula (I) including those 1-arylpyrazoles in which the 4-position is substituted with an acyclic substituent, a cycloalkyl ring structure or heterocyclic ring structure and which compounds are optionally further substituted at the position a to the pyrazole ring, and pharmaceutically acceptable salts and solvates thereof, to compositions comprising such compounds, processes to their synthesis and their use as parasiticides.

专利号:US-7645786-B2
优先权日:2005-06-15
标题:Substituted arylpyrazoles
发明人：BILLEN DENIS; BOYLE JESSICA; CRITCHER DOUGLAS JAMES; GETHIN DAVID MORRIS; HALL KIM THOMAS; KYNE GRAHAM MICHAEL
权利人:PFIZER
摘要:This invention relates to a range of 1-aryl-4-cyclopropylpyrazoles in which the cyclopropyl ring is substituted at the angular position, and pharmaceutically acceptable salts and solvates thereof, to compositions comprising such compounds, processes to their synthesis and their use as parasiticides.