CAS: 80-08-0; 4,4'-Sulfonyldianiline

• 英文名称4,4'-Sulfonyldianiline
• 中文名称4,4’-二氨基二苯砜
• IUPAC名称4,4'-sulfonyldianiline
• 其它别名氨苯砜; 二氨基二苯砜; 达普松; 4,4′-Diaminodiphenyl Sulfone; Dds
• CAS编号80-08-0
• MFCD编号:MFCD00007887
• EINECS号:201-248-4
• FDA UNII编号:8W5C518302
• 分子式:C12H12N2O2S
• 分子量:248.3
• 产品CID: 2512640
• 产品分类有机原料→分子砌块→芳环类化合物→苯类化合物

• 相似结构搜索
• 产品信息参考;;;;
• InChIKey: MQJKPEGWNLWLTK-UHFFFAOYSA-N
• InChI=1S/C12H12N2O2S/c13-9-1-5-11(6-2-9)17(15,16)12-7-3-10(14)4-8-12/h1-8H,13-14H2…
• 计算化学: 氢键受体数4.0氢键供体数2可旋转键数2

物理性质

• 熔点173-178°C
• 沸点511.7°C at 760 mmHg
• 闪点263.2±25.9 °C
• 密度1.4±0.1 g/cm3
• PH:5.5-7.5 (H2O, 20°C)(saturated aqueous solution)
• pKa:pKb 13.0(at 25°C)
• PSA:86.18
• LogP:1.6838
• 折射率1.662
• 蒸汽压0.0±1.3 mmHg at 25°C
• 溶解性0.38G/l
• 敏感性在空气中稳定，无臭，味微苦，中等毒性。操作人员应穿戴防护用具，防止接触眼睛，皮肤及衣物，防止误食及吸入。
• 外观形态白色至米色结晶粉末
• 储存条件2-8°C
• 产品应用用作环氧树脂固化剂,气相色谱固定液.
• 性质描述熔点173-178°C,水溶性<0.1g/100mLat20°C

MSDS等安全信息

• GHS象形图
• GHS符号GHS07;
  注释: Exclamation mark
• 危险类别急性毒性 类别4(经口)
  生殖毒性 类别1B
  急性毒性 类别3(经口)
  STOT SE 2
  特定目标器官毒性-重复接触 类别2
  水生慢性毒性 类别2
  特定目标器官毒性-重复接触 类别1
• 警示词Warning(警告)
• 危险描述H302 |吞咽有害.
  H360F |可能损害生育能力.
  H301 |吞咽会中毒.
  H371 |可能损害器官.
  H373 |长期或反复接触可能损害器官.
  H411 |对水生生物有毒并具有长期持续影响.
  H372 |长期或反复接触损害器官.
• 防范说明P260-P264-P270-P273-P330-P391-P405-P501
• 危险等级9
• UN编号3077.0
• 危险品标志Xn
• 包装等级Ⅲ
• 安全声明22
• 危险类别码22
• WGK Germany1

欧盟法规

上下游产品

合成工艺路线路线简述

• 合成目标产物 4,4'-Diaminodiphenylsulfone 主要起始原料 4,4'-Dichlorodiphenyl Sulfone
• 80-07-9 = 80-08-0
  反应条件:1.1 Reagents: Copper Oxide (Cu2O),Ammonia Solvents: Dimethyl Sulfoxide,Water; 20 H,90 °C
  标题:Catalyst-Free Electrochemical Sulfonylation Of Organoboronic Acids
  作者:Yao,Weiwei; Et Al
  参考文献:Journal Of Organic Chemistry 日期:2023 卷标:88(4) 页码:2296-2305]
  
  1156-50-9 = 80-08-0
  反应条件:1.1 Reagents: Sodium Dithionite Solvents: Methanol,Water; 2 H,Rt
  标题:Cu(Oac)2 Mediated Homo-Coupling With Arylsulfonyl Hydrazides To Synthesize Biarylsulfone
  作者:Wang,Jianwei; Et Al
  参考文献:Youji Huaxue 日期:2014 卷标:34(4) 页码:767-773]
  
  7300-27-8 = 80-08-0
  反应条件:1.1 Reagents: Sodium Sulfide Hydrate Catalysts: Methanol; 5 Min,Rt
  标题:Chemoselective Reduction Of Azides With Sodium Sulfide Hydrate Under Solvent Free Conditions
  作者:Kazemi,Foad; Et Al
  参考文献:Phosphorus 日期:2004 卷标:179(9) 页码:1813-1817]
  
  5423-16-5 = 80-08-0
  反应条件:1.1 Reagents: Potassium Dichromate Solvents: Sulfuric Acid
  标题:Friedel-Crafts Reactions With Halides Containing Sulfur. I. A Synthesis Of 4,4'-Diaminodiphenyl Sulfone
  作者:Sugasawa,Sigehiko; Et Al
  参考文献:Yakugaku Zasshi 日期:1940 卷标:60 页码:22-4]
  
  101-59-7 = 80-08-0 [标题:Reaction Conditions
  标题:Exploration Of The Mechanism And Scope Of The Cui/dabco Catalysed C-S Coupling Reaction
  作者:Thomas,Anns Maria; Et Al
  参考文献:Polyhedron 日期:2020 卷标:176]
  
  77-46-3 = 80-08-0
  反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Water; 1.5 H,Reflux; 1 H,Reflux1.2 Reagents: Sodium Hydroxide Solvents: Water; Ph 14,Reflux -> Rt
  标题:Synthesis Of Deuterated 4,4'-Diaminodiphenylsulfone (Dapsone) And Related Analogs
  作者:Gannett,Peter M.; Et Al
  参考文献:Journal Of Labelled Compounds & Radiopharmaceuticals 日期:2003 卷标:46(2) 页码:107-114]
  
  1775-37-7 = 80-08-0
  反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Water2.1 Reagents: Hydrogen Catalysts: Nickel
  标题:Antiparasitic Agents: Part 5. Synthesis Of 4-[(Substituted-Aryl)Amino]-7-Chloroquinolines As Potential Antimalarial Agents
  作者:Chauhan,P. M. S.; Et Al
  参考文献:Indian Journal Of Chemistry 日期:1986 卷标:(11) 页码:1142-5]
  
  2050-48-8 = 80-08-0
  反应条件:1.1 Reagents: Ammonia Catalysts: Copper Oxide (Cu2O) Solvents: Dimethyl Sulfoxide,Water; 20 H,90 °C
  标题:The Synthesis Of Diarylsulfones With Simple Arenes And K2S2O8 Through Double C-S Bond Formation
  作者:Yang,Yiqing; Et Al
  参考文献:Chemical Communications (Cambridge 日期:2014 卷标:50(95) 页码:15037-15040]
  
  2050-48-8 = 80-08-0 [标题:Reaction Conditions
  标题:Preparation Of Bis(4-Bromophenyl)Sulfone
  参考文献:Germany]
  
  1156-50-9 = 80-08-0
  反应条件:1.1 Reagents: Hydrazine Hydrate (1:1) Solvents: Isopropanol; Rt -> 80 °C; 3 - 6 H,80 °C
  标题:Reduction Of Aromatic Nitro Compounds With Hydrazine Hydrate In Presence Of H-Transfer Catalyst
  作者:Lu,Rong-Wen; Et Al
  参考文献:Ranliao Yu Ranse 日期:2005 卷标:42(3) 页码:43-46]
  
  = 80-08-0
  反应条件:1.1 Reagents: Chromium Trioxide,Thionyl Chloride
  标题:Chemical Synthesis And Characterization Of Poly(Phenylhydrazine-Co-4,4'-Diaminodiphenyl Sulphone)
  作者:Ilangeswaran,D.; Et Al
  参考文献:Chemical Science Transactions 日期:2015 卷标:4(2) 页码:620-628]
  
  139-65-1 = 80-08-0
  反应条件:1.1 Reagents: Water,N-Fluorobenzenesulfonimide; 24 H,Rt
  标题:Selective Synthesis Of Sulfoxides And Sulfones Via Controllable Oxidation Of Sulfides With N-Fluorobenzenesulfonimide
  作者:Xu,Xiaobo; Et Al
  参考文献:Organic & Biomolecular Chemistry 日期:2021 卷标:19(40) 页码:8691-8695]
  
  139-65-1 = 80-08-0
  反应条件:1.1 Reagents: Sodium Periodate Catalysts: Ruthenium(1+),[n1,N2-Bis(1-Methyl-4(1H)-Pyridinylidene)Ethanediamide-Kn1,Kn2]Ch... Solvents: Acetonitrile,Dichloromethane,Water; 3 H,25 °C
  标题:Pyridylidene Amide Ru Complex For Selective Oxidation In Organic Synthesis
  作者:Bertini,Simone; Et Al
  参考文献:Organic Letters 日期:2022 卷标:24(6) 页码:1378-1382]
  
  139-65-1 = 80-08-0
  反应条件:1.1 Reagents: Hydrogen Peroxide Catalysts: Acrylamide-Acrylic Acid-N,N′-Methylenebisacrylamide Copolymer,Potassium Tungsten Vanadium Oxide Silicate (K6W10V2O36(Sio4)) Solvents: Acetonitrile; 24 H,25 °C
  标题:A Green And Reusable Catalytic System Based On Silicopolyoxotungstovanadates Incorporated In A Polymeric Material For The Selective Oxidation Of Sulfides To Sulfones
  作者:Frenzel,Romina Alejandra; Et Al
  参考文献:Microporous And Mesoporous Materials 日期:2021 卷标:310]
  
  6630-10-0 = 80-08-0
  反应条件:1.1 Reagents: Ammonium Hydroxide Solvents: Water
  标题:Monosubstituted Diaminodiphenyl Sulfones
  作者:Weijlard,John; Et Al
  参考文献:Journal Of The American Chemical Society 日期:1949 卷标:71 页码:4134-5]
  
  101-59-7 = 80-08-0
  反应条件:1.1 Reagents: Hydrochloric Acid,Stannous Chloride Solvents: Ethanol1.2 Reagents: 1,8-Diazabicyclo[5.4.0]Undec-7-Ene,Zinc Chloride,Hydrogen Peroxide Solvents: Methanol
  标题:C-S Coupling With Nitro Group As Leaving Group Via Simple Inorganic Salt Catalysis
  作者:Xuan,Maojie; Et Al
  参考文献:Chinese Chemical Letters 日期:2020 卷标:31(1) 页码:84-90]
  
  77-46-3 = 80-08-0
  反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Water; Rt; 2 H,Reflux
  标题:Synthesis And Characterization Of Reactive Dyes Based On 4,4'-Diaminodiphenyl Sulfone And Their Dyeing Application On Silk,Wool And Cotton Fibers
  作者:Patel,L. A.; Et Al
  参考文献:International Journal For Pharmaceutical Research Scholars 日期:2015 卷标:4(1) 页码:127-134]
  
  77-46-3 = 80-08-0
  反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Water; Rt; 2 H,Reflux; Cooled
  标题:Synthesis And Performance Studies Of Acid Dyes Based On 4,4'-Diaminodiphenyl Sulphone On Various Fibres
  作者:Patel,Bhavesh M.; Et Al
  参考文献:Acta Ciencia Indica 日期:2009 卷标:35(1) 页码:11-18]
  
  1775-37-7 = 80-08-0
  反应条件:1.1 Reagents: Hydrochloric Acid,Tin Dichloride Dihydrate
  标题:4,4'-Diaminodiphenylsulfone (P,P'-Sulfonylbisaniline)
  作者:Ferry,C. W.; Et Al
  参考文献:Organic Syntheses 日期:1942 卷标:22 页码:31-4

海关参考信息

• 2930909099-其他有机硫化合物
  2904990090-其他烃的磺化、硝化、亚硝化衍生物
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• ➥ 防范代码详解
• ➥ 危险代码说明
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