专利号:US-4886910-A 优先权日:1987-02-17 标题 :Cyanoguanidine derivative and process for preparation thereof 发明人:TAN HIROAKI; KATO KOJI; IMUTA JUNICHI; KIHARA NORIAKI 权利人:MITSUI PETROCHEMICAL IND 摘要:The present invention provides a cyanoguanidine derivtive which is a precursor for the synthesis of N-cyano-N'-methyl-N'-[2-{(5-methyl-1H-imidazol-4-yl)methylothio}ethyl]-guanidine (Cimetidine) or its relted compound, which has an action of controlling secretion of acid in the stomach based on the histamine H 2 receptor antagonism and is valuable as a drug for treating gastric ulcer. This cyanoguanidine derivative is prepared by reacting a haloketone derivative with an ammonium salt and a lower fatty acid salt or by reacting other cyanoguanidine derivative with an ammonium salt.
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合成参考文献
参考文献:10.1186/s41021-019-0137-4 摘要:Inami K, Asada Y, Harada T, Okayama Y, Usui N, Mochizuki M. Antimutagenic components in Spatholobus suberectus Dunn against N-methyl-N-nitrosourea. Genes and Environment. 2019 Dec 11;41(1):22. doi: 10.1186/s41021-019-0137-4.