CAS: 7169-97-3; N-(5-Bromopyridin-2-yl)Acetamide

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CAS号1072-97-5 2-氨基-5-溴吡啶 | CAS号108-24-7 乙酸酐 | CAS号75-36-5 乙酰氯 | CAS号705-04-4 N-(5-bromo-1-hy... | CAS号124-41-4 甲醇钠 | CAS号141-78-6 乙酸乙酯 | CAS号64-19-7 冰醋酸 | CAS号4044-99-9 6-溴-2-甲基咪唑并[1,2-a]吡啶 | CAS号904326-87-0 2-乙酰氨基吡啶-5-硼酸频哪醇酯 | CAS号5231-96-9 2-乙酰氨基吡啶 | CAS号167837-43-6 (E)-3-(6-氨基-3-吡... | CAS号705-04-4 N-(5-bromo-1-hy...

2-乙酰氨基吡啶置于n-溴代丁二酰亚胺(Nbs)体系中,用 甲基叔丁基醚 作为反应溶剂,化学反应 12.0H,以55%的收率获得产物2-乙酰氨基-5-溴吡啶
参考文献:可预测的位点选择性功能化:在无金属条件下促进基团辅助 N-取代(杂)芳烃的对位卤化
标题:可预测的位点选择性功能化:在无金属条件下促进基团辅助 N-取代(杂)芳烃的对位卤化
摘要:本文公开了通过 S E Ar(亲电芳族取代)型反应对n-嘧啶基(杂)芳烃进行区域选择性对-C-H 卤化.s E Ar 型反应已用于二氢吲哚的 C5-溴化(对位选择性)与n-溴代琥珀酰亚胺在无金属和无添加剂的条件下具有非常好至极好的收率.所开发的方法也适用于碘化和具有挑战性的氯化.嘧啶基被确定为反应性调节剂,它也控制区域选择性.本方法也适用于苯胺,吡啶,吲哚,羟吲哚,吡唑,四氢喹啉,异喹啉和咔唑的选择性卤化.fukui 亲核性和自然电荷图等 Dft 研究也支持观测到的p-选择性.标题化合物后官能化为相应的芳基化,烯化和二卤化产物是通过一锅两步的方式实现的.还对药物/天然分子(哈明,依托考昔,可乐定和氯唑沙宗)进行了后期 C-H 溴化,以证明所开发方案的适用性.
DOI:10.1039/d1Ob02000E

专利信息

专利号:EP-0842924-B1
优先权日:1996-11-14
标 题 :Pyridine intermediates, useful in the synthesis of beta-adrenergic receptor agonists
发明人：WRIGHT STEPHEN WAYNE
权利人:PFIZER
摘要:The present invention relates to certain compounds of the formula (I), which are useful in the synthesis of certain beta -adrenergic receptor agonists. The invention also relates to a process for synthesizing the compounds of formula (I) and to compounds of the formula (II), wherein R<1>, R<2> and R<4> are defined herein, which are useful in the synthesis of the compounds of formula (I). The invention also relates to a process for synthesizing a compound of formula (II). The invention further relates to processes for synthesizing compounds of formula (Z*), R<1>, R<2> and Y<2*> are defined herein.o

专利号:US-8926801-B2
优先权日:2009-01-16
标题 :Methods of electrospray chemical synthesis and device for use therein
发明人：REHMAN ATIQ
权利人:REHMAN ATIQ; CANAM BIORES INC
摘要:The present invention relates to methods of production of chemical bonds and subsequent molecules by electrospray ionization and the design of an electrospray chemical synthesizer, for use in chemical synthesis and expedited organic chemical reactions.

专利号:US-6008361-A
优先权日:1996-04-09
标题:Substituted pyridines
发明人：WRIGHT STEVEN W
权利人:PFIZER
摘要:The present invention relates to certain compounds of the formula (I), ##STR1## which are useful in the synthesis of certain β-adrenergic receptor agonists. The invention also relates to a process for synthesizing the compounds of formula (I) and to compounds of the formula (II), ##STR2## wherein R 1 , R 2 and R 4 are defined herein, which are useful in the synthesis of the compounds of formula (I). The invention also relates to a process for synthesizing a compound of formula (II). The invention further relates to processes for synthesizing compounds of formula (Z*), ##STR3## R 1 , R 2 and Y 2* are defined herein.

专利号:US-6031105-A
优先权日:1996-04-09
标题:Substituted pyridines
发明人：WRIGHT STEVEN W
权利人:PFIZER
摘要:The present invention relates to certain compounds of the formula (I), ##STR1## which are useful in the synthesis of certian β-adrenergic receptor agonists. The invention also relates to a process for synthesizing the compounds of formula (I) and to compounds of the formula (II), ##STR2## wherein R 1 , R 2 and R 4 are defined herein, which are useful in the synthesis of the compounds of formula (I). The invention also relates to a process for synthesizing a compound of formula (II). The invention further relates to processes for synthesizing compounds of formula (Z*), ##STR3## R 1 , R 2 and Y 2* are defined herein.

专利号:US-8338451-B2
优先权日:2008-03-21
标 题 :Polysubstituted derivatives of 2-heteroaryl-6-phenylimidazo[1,2-a]pyridines, and preparation and therapeutic use thereof
发明人：DE PERETTI DANIELLE; EVANNO YANNICK; LARDENOIS PATRICK; MACHNIK DAVID; RAKOTOARISOA NATHALIE; ALMARIO GARCIA ANTONIO
权利人:DE PERETTI DANIELLE; EVANNO YANNICK; LARDENOIS PATRICK; MACHNIK DAVID; RAKOTOARISOA NATHALIE; ALMARIO GARCIA ANTONIO; SANOFI SA
摘要:Compounds of formula (I): n nwherein R, R 1 , R 2 , R 3 , R 4 and X are as defined in the disclosure, or an acid addition salt thereof, and the therapeutic use and process of synthesis thereof.

专利号:ES-2203762-T3
优先权日:1996-11-14
标题:INTERMEDIATE PYRIDINS USEFUL IN THE SYNTHESIS OF AGONISTS OF THE BETA ADRENERGIC RECEIVER